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    Rnaseh2a ribonuclease H2, subunit A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364974, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rnaseh2aprovided by RGD
    Official Full Name
    ribonuclease H2, subunit Aprovided by RGD
    Primary source
    RGD:1307248
    See related
    EnsemblRapid:ENSRNOG00000003504 AllianceGenome:RGD:1307248
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA-DNA hybrid ribonuclease activity. Predicted to be involved in DNA replication, removal of RNA primer and mismatch repair. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of ribonuclease H2 complex. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human RNASEH2A (ribonuclease H2 subunit A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 749.9), Adrenal (RPKM 300.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rnaseh2a in Genome Data Viewer
    Location:
    19q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (40091206..40100904)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (23186325..23196045)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (26074980..26084780, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene JunB proto-oncogene, AP-1 transcription factor subunit Neighboring gene peroxiredoxin 2 Neighboring gene retbindin Neighboring gene microtubule associated serine/threonine kinase 1 Neighboring gene microRNA 3550

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The structural and biochemical characterization of human RNase H2 complex reveals the molecular basis for substrate recognition and Aicardi-Goutières syndrome defects. Figiel M, et al. J Biol Chem, 2011 Mar 25. PMID 21177858, Free PMC Article
    2. The structure of the mammalian RNase H2 complex provides insight into RNA.NA hybrid processing to prevent immune dysfunction. Shaban NM, et al. J Biol Chem, 2010 Feb 5. PMID 19923215, Free PMC Article
    3. Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair. Ghodgaonkar MM, et al. Mol Cell, 2013 May 9. PMID 23603115, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA-DNA hybrid ribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA-DNA hybrid ribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA-DNA hybrid ribonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication, removal of RNA primer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mismatch repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonuclease H2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonuclease H2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonuclease H2 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ribonuclease H2 subunit A
    Names
    RNase H2 subunit A
    RNase HI large subunit
    ribonuclease H2, large subunit
    ribonuclease HI large subunit
    ribonuclease HI subunit A
    NP_001013252.1
    XP_038953836.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013234.2 → NP_001013252.1  ribonuclease H2 subunit A

      See identical proteins and their annotated locations for NP_001013252.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      Q5U209
      UniProtKB/TrEMBL
      A6IY50, A6IY52
      Related
      ENSRNOP00000070694.3, ENSRNOT00000083159.3
      Conserved Domains (1) summary
      cd07181
      Location:31 → 251
      RNase_HII_eukaryota_like; Eukaryotic RNase HII

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      40091206..40100904
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097908.2 → XP_038953836.1  ribonuclease H2 subunit A isoform X1

      Conserved Domains (1) summary
      cd07181
      Location:18 → 158
      RNase_HII_eukaryota_like; Eukaryotic RNase HII
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U209.1 GenPept UniProtKB/Swiss-Prot:Q5U209

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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