Pea15 proliferation and apoptosis adaptor protein 15 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pea15provided by RGD
Official Full Name: proliferation and apoptosis adaptor protein 15provided by RGD
Primary source: RGD:1306055
See related: AllianceGenome:RGD:1306055
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pea15a
Summary: Predicted to be involved in negative regulation of D-glucose import and negative regulation of extrinsic apoptotic signaling pathway via death domain receptors. Predicted to act upstream of or within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors. Predicted to be located in cytosol and nucleoplasm. Orthologous to human PEA15 (proliferation and apoptosis adaptor protein 15). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 513.3), Heart (RPKM 217.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (87190189..87199811, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (84657815..84667437, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (90579844..90589466, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of PEA15 was able to attenuate the neurotoxicity of propofol in rat hippocampal neurons.
Title: Overexpression of phosphoprotein enriched in astrocytes 15 reverses the damage induced by propofol in hippocampal neurons.
The selective manipulation of PEA15 phosphorylations may regulate apoptotic and/or proliferative signals in astrocytes.
Title: The differential roles of PEA15 phosphorylations in reactive astrogliosis and astroglial apoptosis following status epilepticus.
a diabetic condition may aggravate brain damage through decreasing expression of PEA-15 and phospho-PEA-15 in ischemic brain injury
Title: Hyperglycemia aggravates decreases of PEA-15 and its two phosphorylated forms in cerebral ischemia.
biomechanical insult dramatically switches PEA-15 phosphorylation and function to uncouple its anti-apoptotic activity
Title: Biomechanical insult switches PEA-15 activity to uncouple its anti-apoptotic function and promote erk mediated tissue remodeling.
The protective effect of melatonin is likely mediated, in part, by inhibition of peroxynitrate-mediated nitrosative stress, which in turn relieves imbalance of mitochondrial HtrA2-PED signaling and endothelial cell death.
Title: Melatonin ameliorates ischemic-like injury-evoked nitrosative stress: Involvement of HtrA2/PED pathways in endothelial cells.
disruption of the PED/PEA-15-PLD1 molecular interaction enhances insulin sensitivity in skeletal muscle cells
Title: Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells.

Submit: New GeneRIF Correction

General gene information

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Markers

BI286597 (e-PCR)
- UniSTS:245349

RH132632 (e-PCR)
- UniSTS:215915

D10Bir17 (e-PCR), detects polymorphism
- UniSTS:141482

RH132968 (e-PCR)
- UniSTS:216251

G49234 (e-PCR)
- UniSTS:108990

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of D-glucose import	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of D-glucose import	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: astrocytic phosphoprotein PEA-15

Names: 15 kDa phosphoprotein enriched in astrocytes; phosphoprotein enriched in astrocytes 15; phosphoprotein enriched in astrocytes 15A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013231.1 → NP_001013249.1 astrocytic phosphoprotein PEA-15

See identical proteins and their annotated locations for NP_001013249.1

Status: PROVISIONAL

Source sequence(s)

BC085766

UniProtKB/Swiss-Prot

Q5U318, Q78ZC9

UniProtKB/TrEMBL

A0A8I6AA10, A6JG35

Conserved Domains (1) summary

cd08338
Location:2 → 85

DED_PEA15; Death Effector Domain of Astrocyte phosphoprotein PEA-15