Cckbr cholecystokinin B receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cckbrprovided by RGD
Official Full Name: cholecystokinin B receptorprovided by RGD
Primary source: RGD:2290
See related: EnsemblRapid:ENSRNOG00000017679 AllianceGenome:RGD:2290
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cck2r; Cholrec
Summary: Cholecystokinin was one of the first gastrointestinal peptides discovered in the mammalian brain. Cholecystokinin receptors are members of the G protein-coupled receptor superfamily, stimulating phosphatidylinositol turnover and intracellular calcium mobilization. This gene encodes a cholecystokinin receptor of the B subtype. These receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. [provided by RefSeq, Jul 2008]
Expression: Restricted expression toward (RPKM 39.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (169183578..169193583)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (159771733..159781738)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (170262218..170272298)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intestinal Gastrin/CCKBR (Cholecystokinin B Receptor) Ameliorates Salt-Sensitive Hypertension by Inhibiting Intestinal Na(+)/H(+) Exchanger 3 Activity Through a PKC (Protein Kinase C)-Mediated NHERF1 and NHERF2 Pathway.
Title: Intestinal Gastrin/CCKBR (Cholecystokinin B Receptor) Ameliorates Salt-Sensitive Hypertension by Inhibiting Intestinal Na(+)/H(+) Exchanger 3 Activity Through a PKC (Protein Kinase C)-Mediated NHERF1 and NHERF2 Pathway.
treatment with gastrin, a CCK2R agonist, stimulated the secretion of GLP-1, and that this effect was likely due to increased expression of proglucagon and PCSK1 (also known as prohormone convertase 3 (PC3 gene)).
Title: Expression of cholecystokinin2-receptor in rat and human L cells and the stimulation of glucagon-like peptide-1 secretion by gastrin treatment.
CCK-B receptors mediate acetylcholine release through cell bodies of cholinergic interneurons in the corpus striatum.
Title: Modulation of acetylcholine release by cholecystokinin in striatum: receptor specificity; role of dopaminergic neuronal activity.
CCK1 and CCK2 receptors are expressed on pancreatic stellate cells and induce collagen production
Title: CCK1 and CCK2 receptors are expressed on pancreatic stellate cells and induce collagen production.
Pancreatic islet CCK1/2 receptors initiate somatosatin secretion through constitutive secretion controlled at the level of protein synthesis.
Title: Control of somatostatin (SS) secretion by CCK-1 and CCK-2 receptors' occupation in RIN-14B cells, a rat pancreatic islet cell line.
Our data indicate that CCK, acting via CCK(B) receptors, produces a long-lasting excitation of layer 6b neocortical neurons, and this action may play a critical role in modulation of corticothalamic circuit activity.
Title: Cholecystokinin action on layer 6b neurons in somatosensory cortex.
CCK modulates glutamate-GABA mechanisms by acting on CCK-2 receptors via volume transmission occurring at basolateral amygdaloid nucleus and/or by synaptic or perisynaptic volume transmission in rostrolateral main and paracapsular intercalated islands.
Title: Role of the amygdaloid cholecystokinin (CCK)/gastrin-2 receptors and terminal networks in the modulation of anxiety in the rat. Effects of CCK-4 and CCK-8S on anxiety-like behaviour and [3H]GABA release.
Functional postsynaptic G-protein-coupled CCK B receptors are prevalent in neonatal rodent spinal cord.
Title: Cholecystokinin B-type receptors mediate a G-protein-dependent depolarizing action of sulphated cholecystokinin ocatapeptide (CCK-8s) on rodent neonatal spinal ventral horn neurons.
CCK(2) receptors located in the peraqueductal gray are involved in the regulation of panic-related behaviors and may mediate the effect of cholecystokinin-4 on panic.
Title: Cholecystokinin-2 receptors modulate freezing and escape behaviors evoked by the electrical stimulation of the rat dorsolateral periaqueductal gray.
CCK(B) receptor mediates synergistic stimulation of DNA synthesis and cyclin expression
Title: CCK(B)/gastrin receptor mediates synergistic stimulation of DNA synthesis and cyclin D1, D3, and E expression in Swiss 3T3 cells.

Submit: New GeneRIF Correction See all GeneRIFs (20)

General gene information

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Markers

D1Bda31 (e-PCR)
- UniSTS:239778

RH142004 (e-PCR)
- UniSTS:223995

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cholecystokinin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cholecystokinin receptor activity	IEA Inferred from Electronic Annotation more info
enables cholecystokinin receptor activity	ISO Inferred from Sequence Orthology more info
enables gastrin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables gastrin receptor activity	IEA Inferred from Electronic Annotation more info
enables gastrin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables gastrin receptor activity	ISO Inferred from Sequence Orthology more info
enables gastrin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables neuropeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	IEA Inferred from Electronic Annotation more info
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info
enables type B gastrin/cholecystokinin receptor binding	IEA Inferred from Electronic Annotation more info
enables type B gastrin/cholecystokinin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in behavioral defense response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholecystokinin signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cholecystokinin signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in digestive tract development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within digestive tract development	ISO Inferred from Sequence Orthology more info
involved_in estrous cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in gastric acid secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gastric acid secretion	ISO Inferred from Sequence Orthology more info
involved_in gland development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gland development	ISO Inferred from Sequence Orthology more info
involved_in histamine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in pH reduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pH reduction	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of behavioral fear response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of somatostatin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic transmission, GABAergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: gastrin/cholecystokinin type B receptor

Names: CCK-B receptor; CCK-BR; CCK2 receptor; CCK2-R; cholecystokinin-2 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013165.3 → NP_037297.2 gastrin/cholecystokinin type B receptor

Status: REVIEWED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P30553

UniProtKB/TrEMBL

A6I7I2, G3V8A8

Related

ENSRNOP00000024077.1, ENSRNOT00000024077.5

Conserved Domains (2) summary

cd14964
Location:56 → 82

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:55 → 406

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily