Mx1 MX dynamin like GTPase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mx1provided by RGD
Official Full Name: MX dynamin like GTPase 1provided by RGD
Primary source: RGD:3127
See related: EnsemblRapid:ENSRNOG00000001959 AllianceGenome:RGD:3127
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: IFI78
Summary: Predicted to enable GTPase activity; identical protein binding activity; and microtubule binding activity. Involved in response to virus. Located in nucleus. Human ortholog(s) of this gene implicated in alopecia areata; avian influenza; liver disease; and prostate cancer. Orthologous to human MX1 (MX dynamin like GTPase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 356.1), Thymus (RPKM 152.3) and 6 other tissues See more
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Genomic context

Location:: 11q12

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (50269056..50294699, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (36799659..36825209, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (37891150..37916775, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Six differentially expressed genes (Kcne1, Rcan1, Mx1, Mx2, Tmprss2, and RGD1559516) were identified in the renal cortex, and three genes (Rcan1, Mx2, and Tmprss2) were identified in the renal medulla.
Title: [Differentially expressed genes in the locus associated with relative kidney weight and resting blood pressure in hypertensive rats of the ISIAH strain].
IFN treatment induced Mx production and increased PKR production in immature germ cells
Title: Production of the antiviral proteins 2'5'oligoadenylate synthetase, PKR and Mx in interstitial cells and spermatogonia.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in interleukin-27-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in response to virus	IEA Inferred from Electronic Annotation more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interferon-induced GTP-binding protein Mx1

Names: Myxovirus (influenza) resistance, homolog of murine Mx (also interferon-inducible protein IFI78); myxoma resistance protein 1; myxovirus (influenza virus) resistance 1; myxovirus resistance protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271058.1 → NP_001257987.1 interferon-induced GTP-binding protein Mx1

See identical proteins and their annotated locations for NP_001257987.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.

Source sequence(s)

BC099784, JAXUCZ010000011

UniProtKB/Swiss-Prot

P18588

UniProtKB/TrEMBL

F7EXA4, Q499S4

Conserved Domains (3) summary

smart00302
Location:559 → 650

GED; Dynamin GTPase effector domain

cd08771
Location:59 → 331

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:251 → 540

Dynamin_M; Dynamin central region
NM_001271059.1 → NP_001257988.1 interferon-induced GTP-binding protein Mx1

See identical proteins and their annotated locations for NP_001257988.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.

Source sequence(s)

BC099784, JAXUCZ010000011

UniProtKB/Swiss-Prot

P18588

UniProtKB/TrEMBL

F7EXA4, Q499S4

Conserved Domains (3) summary

smart00302
Location:559 → 650

GED; Dynamin GTPase effector domain

cd08771
Location:59 → 331

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:251 → 540

Dynamin_M; Dynamin central region
NM_001271060.1 → NP_001257989.1 interferon-induced GTP-binding protein Mx1

See identical proteins and their annotated locations for NP_001257989.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.

Source sequence(s)

BC099784, JAXUCZ010000011

UniProtKB/Swiss-Prot

P18588

UniProtKB/TrEMBL

F7EXA4, Q499S4

Conserved Domains (3) summary

smart00302
Location:559 → 650

GED; Dynamin GTPase effector domain

cd08771
Location:59 → 331

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:251 → 540

Dynamin_M; Dynamin central region
NM_001271061.1 → NP_001257990.1 interferon-induced GTP-binding protein Mx1

See identical proteins and their annotated locations for NP_001257990.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.

Source sequence(s)

BC099784, JAXUCZ010000011

UniProtKB/Swiss-Prot

P18588

UniProtKB/TrEMBL

F7EXA4, Q499S4

Conserved Domains (3) summary

smart00302
Location:559 → 650

GED; Dynamin GTPase effector domain

cd08771
Location:59 → 331

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:251 → 540

Dynamin_M; Dynamin central region
NM_001271062.1 → NP_001257991.1 interferon-induced GTP-binding protein Mx1

See identical proteins and their annotated locations for NP_001257991.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.

Source sequence(s)

BC099784, JAXUCZ010000011

UniProtKB/Swiss-Prot

P18588

UniProtKB/TrEMBL

F7EXA4, Q499S4

Conserved Domains (3) summary

smart00302
Location:559 → 650

GED; Dynamin GTPase effector domain

cd08771
Location:59 → 331

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:251 → 540

Dynamin_M; Dynamin central region
NM_173096.3 → NP_775119.2 interferon-induced GTP-binding protein Mx1

See identical proteins and their annotated locations for NP_775119.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. All six variants encode the same protein.

Source sequence(s)

BC099784, JAXUCZ010000011

UniProtKB/Swiss-Prot

P18588

UniProtKB/TrEMBL

F7EXA4, Q499S4

Related

ENSRNOP00000043001.3, ENSRNOT00000039876.7

Conserved Domains (3) summary

smart00302
Location:559 → 650

GED; Dynamin GTPase effector domain

cd08771
Location:59 → 331

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:251 → 540

Dynamin_M; Dynamin central region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

50269056..50294699 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017597877.3 → XP_017453366.1 interferon-induced GTP-binding protein Mx1 isoform X1

UniProtKB/Swiss-Prot

P18588

UniProtKB/TrEMBL

F7EXA4, Q499S4

Conserved Domains (3) summary

smart00302
Location:559 → 650

GED; Dynamin GTPase effector domain

cd08771
Location:59 → 331

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:251 → 540

Dynamin_M; Dynamin central region
XM_006248146.5 → XP_006248208.1 interferon-induced GTP-binding protein Mx1 isoform X1

See identical proteins and their annotated locations for XP_006248208.1

UniProtKB/Swiss-Prot

P18588

UniProtKB/TrEMBL

F7EXA4, Q499S4

Conserved Domains (3) summary

smart00302
Location:559 → 650

GED; Dynamin GTPase effector domain

cd08771
Location:59 → 331

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:251 → 540

Dynamin_M; Dynamin central region
XM_063270276.1 → XP_063126346.1 interferon-induced GTP-binding protein Mx1 isoform X1

UniProtKB/TrEMBL

F7EXA4, Q499S4
XM_039087955.2 → XP_038943883.1 interferon-induced GTP-binding protein Mx1 isoform X1

UniProtKB/Swiss-Prot

P18588

UniProtKB/TrEMBL

F7EXA4, Q499S4

Conserved Domains (3) summary

smart00302
Location:559 → 650

GED; Dynamin GTPase effector domain

cd08771
Location:59 → 331

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:251 → 540

Dynamin_M; Dynamin central region
XM_017597878.3 → XP_017453367.1 interferon-induced GTP-binding protein Mx1 isoform X1

UniProtKB/Swiss-Prot

P18588

UniProtKB/TrEMBL

F7EXA4, Q499S4

Conserved Domains (3) summary

smart00302
Location:559 → 650

GED; Dynamin GTPase effector domain

cd08771
Location:59 → 331

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:251 → 540

Dynamin_M; Dynamin central region
XM_039087956.2 → XP_038943884.1 interferon-induced GTP-binding protein Mx1 isoform X1

UniProtKB/Swiss-Prot

P18588

UniProtKB/TrEMBL

F7EXA4, Q499S4

Conserved Domains (3) summary

smart00302
Location:559 → 650

GED; Dynamin GTPase effector domain

cd08771
Location:59 → 331

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:251 → 540

Dynamin_M; Dynamin central region