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    Fgf12 fibroblast growth factor 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170630, updated on 9-Dec-2024

    Summary

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    Symbol
    Fgf12provided by RGD
    Full Name
    fibroblast growth factor 12provided by RGD
    Primary source
    RGD:620163
    See related
    EnsemblRapid:ENSRNOG00000090378 AllianceGenome:RGD:620163
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fhf1; Fgf1a; Fhf1b
    Summary
    Enables sodium channel regulator activity and transmembrane transporter binding activity. Involved in negative regulation of cation channel activity; regulation of membrane depolarization; and regulation of sodium ion transmembrane transporter activity. Predicted to be located in synapse. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 47. Orthologous to human FGF12 (fibroblast growth factor 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 421.1), Heart (RPKM 185.9) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fgf12 in Genome Data Viewer
    Location:
    11q22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (85501947..86069543)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (71997151..72564757)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (75606360..76171078)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene Mab-21 domain containing 2 Neighboring gene 60S ribosomal protein L26-like 1 pseudogene Neighboring gene uncharacterized LOC134481099 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC102548576 Neighboring gene coiled-coil domain containing 50

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Quantitative proteomics reveals protein-protein interactions with fibroblast growth factor 12 as a component of the voltage-gated sodium channel 1.2 (nav1.2) macromolecular complex in Mammalian brain. Wildburger NC, et al. Mol Cell Proteomics, 2015 May. PMID 25724910, Free PMC Article
    2. Fibroblast Growth Factor 12 Is a Novel Regulator of Vascular Smooth Muscle Cell Plasticity and Fate. Song SH, et al. Arterioscler Thromb Vasc Biol, 2016 Sep. PMID 27470512
    3. MiR-107 Aggravates Oxygen-Glucose Deprivation/Reoxygenation (OGD/R)-Induced Injury Through Inactivating PI3K-AKT Signalling Pathway by Targeting FGF9/FGF12 in PC12 Cells. Fan Q, et al. J Stroke Cerebrovasc Dis, 2022 Apr. PMID 35093630
    4. Fibroblast growth factor homologous factors control neuronal excitability through modulation of voltage-gated sodium channels. Goldfarb M, et al. Neuron, 2007 Aug 2. PMID 17678857, Free PMC Article
    5. Fibroblast growth factor homologous factor 1B binds to the C terminus of the tetrodotoxin-resistant sodium channel rNav1.9a (NaN). Liu Cj, et al. J Biol Chem, 2001 Jun 1. PMID 11376006

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-107 Aggravates Oxygen-Glucose Deprivation/Reoxygenation (OGD/R)-Induced Injury Through Inactivating PI3K-AKT Signalling Pathway by Targeting FGF9/FGF12 in PC12 Cells.
      Title: MiR-107 Aggravates Oxygen-Glucose Deprivation/Reoxygenation (OGD/R)-Induced Injury Through Inactivating PI3K-AKT Signalling Pathway by Targeting FGF9/FGF12 in PC12 Cells.
    2. FGF12 strongly induced the quiescent and contractile vascular smooth muscle cell phenotype and directly promoted VSMC lineage differentiation.
      Title: Fibroblast Growth Factor 12 Is a Novel Regulator of Vascular Smooth Muscle Cell Plasticity and Fate.
    3. Fibroblast growth factor 12 is a component of the voltage-gated sodium channel 1.2 (nav1.2) macromolecular complex in the rat brain.
      Title: Quantitative proteomics reveals protein-protein interactions with fibroblast growth factor 12 as a component of the voltage-gated sodium channel 1.2 (nav1.2) macromolecular complex in Mammalian brain.
    4. Sodium channels in Fhf1-/-Fhf4-/- granule neurons inactivate at more negative membrane potential, inactivate more rapidly, and are slower to recover from the inactivated state.
      Title: Fibroblast growth factor homologous factors control neuronal excitability through modulation of voltage-gated sodium channels.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables fibroblast growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sodium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within adult locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuromuscular process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of membrane depolarization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of neuronal action potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of neuronal action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuronal action potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of sodium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of sodium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of voltage-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of voltage-gated sodium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of voltage-gated sodium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fibroblast growth factor 12
    Names
    FGF-12
    FHF-1
    fibroblast growth factor 1a
    fibroblast growth factor homologous factor 1
    fibroblast growth factor homologous factor 1b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395084.1 → NP_001382013.1  fibroblast growth factor 12 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A6JRX5, A6JRX6
      Related
      ENSRNOP00000002650.2, ENSRNOT00000002650.6
      Conserved Domains (1) summary
      pfam00167
      Location:12 → 136
      FGF; Fibroblast growth factor

    2. NM_130814.2 → NP_570827.2  fibroblast growth factor 12 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      P61150
      UniProtKB/TrEMBL
      A0A7U3L6G2
      Related
      ENSRNOP00000111324.1, ENSRNOT00000158744.1
      Conserved Domains (1) summary
      pfam00167
      Location:74 → 198
      FGF; Fibroblast growth factor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      85501947..86069543
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597854.3 → XP_017453343.1  fibroblast growth factor 12 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A2F9, A6JRX6
      Conserved Domains (1) summary
      pfam00167
      Location:38 → 162
      FGF; Fibroblast growth factor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61150.1 GenPept UniProtKB/Swiss-Prot:P61150

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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