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    Ifit1 interferon-induced protein with tetratricopeptide repeats 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 56824, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ifit1provided by RGD
    Official Full Name
    interferon-induced protein with tetratricopeptide repeats 1provided by RGD
    Primary source
    RGD:620599
    See related
    EnsemblRapid:ENSRNOG00000019050 AllianceGenome:RGD:620599
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Garg16
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in defense response to virus. Predicted to act upstream of or within cellular response to interferon-alpha; cellular response to interferon-beta; and response to bacterium. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to several human genes including IFIT1B (interferon induced protein with tetratricopeptide repeats 1B). [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Annotation category: partial on reference assembly
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    Genomic context

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    See Ifit1 in Genome Data Viewer
    Location:
    1q53
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (241565197..241567262)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (232152038..232154103)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (252944105..252946170)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene interferon-induced protein with tetratricopeptide repeats 3 Neighboring gene small nucleolar RNA SNORA71 Neighboring gene interferon-induced protein with tetratricopeptide repeats 1B-like Neighboring gene solute carrier family 16, member 12 Neighboring gene uncharacterized LOC134485224

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lipopolysaccharide-induced switch between retinoid receptor (RXR) alpha and glucocorticoid attenuated response gene (GARG)-16 messenger RNAs in cultured rat microglia. Kitamura Y, et al. J Neurosci Res, 2001 Jun 15. PMID 11398178
    2. The interaction between interferon-induced protein with tetratricopeptide repeats-1 and eukaryotic elongation factor-1A. Li HT, et al. Mol Cell Biochem, 2010 Apr. PMID 19856081
    3. Structure, chromosome localization, and regulation of expression of the interferon-regulated mouse Ifi54/Ifi56 gene family. Bluyssen HA, et al. Genomics, 1994 Nov 1. PMID 7896268
    4. Interferon-induced Ifit proteins: their role in viral pathogenesis. Fensterl V, et al. J Virol, 2015 Mar. PMID 25428874, Free PMC Article
    5. 2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members. Daffis S, et al. Nature, 2010 Nov 18. PMID 21085181, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to interferon-alpha ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to interferon-beta ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interferon-induced protein with tetratricopeptide repeats 1-like protein
    Names
    glucocorticoid-attenuated response gene 16 product

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020096.1 → NP_064481.1  interferon-induced protein with tetratricopeptide repeats 1-like protein

      See identical proteins and their annotated locations for NP_064481.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ276893
      UniProtKB/TrEMBL
      A6I137, Q9JJT1
      Related
      ENSRNOP00000099636.1, ENSRNOT00000132040.1
      Conserved Domains (2) summary
      pfam04733
      Location:158 → 421
      Coatomer_E; Coatomer epsilon subunit
      sd00006
      Location:242 → 270
      TPR; TPR repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      241565197..241567262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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