Sell selectin L [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sellprovided by RGD
Official Full Name: selectin Lprovided by RGD
Primary source: RGD:3655
See related: EnsemblRapid:ENSRNOG00000002776 AllianceGenome:RGD:3655
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: A.11; LECAM-1; L-selectin
Summary: Enables glycolipid binding activity. Involved in several processes, including positive regulation of neutrophil chemotaxis; response to hyperoxia; and response to linoleic acid. Located in cell surface. Used to study colitis and peripheral vascular disease. Biomarker of abdominal aortic aneurysm; endometriosis; pancreatitis; and toxic shock syndrome. Human ortholog(s) of this gene implicated in Crohn's disease; IgA glomerulonephritis; and ulcerative colitis. Orthologous to human SELL (selectin L). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 587.9), Thymus (RPKM 264.3) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 13q23

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (78950100..78969604)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (76416969..76436444)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (82369820..82387774)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

L-selectin levels are not only down-regulated during T-cell activation but also routinely reduced while transmigrating within lymph nodes.
Title: Cyclical expression of L-selectin (CD62L) by recirculating T cells.
These results show that NO, produced at physiological levels, controls expression of constitutive adhesion molecules L-selectin and PECAM-1 in cell membranes by different mechanisms of action.
Title: In vivo blockade of Ca(+2)-dependent nitric oxide synthases impairs expressions of L-selectin and PECAM-1.
L-selectin-mediated neutrophil recruitment may be a critical early step in AAA formation.
Title: L-selectin-mediated neutrophil recruitment in experimental rodent aneurysm formation.
Data show that upon experimental and human renal ischemia/reperfusion, microvascular basement membrane (BM) heparan sulfate proteoglycans (collagen 18alpha1, agrin and perlecan) are modified to bind L-selectin and monocyte chemoattractant protein-1.
Title: Subendothelial heparan sulfate proteoglycans become major L-selectin and monocyte chemoattractant protein-1 ligands upon renal ischemia/reperfusion.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables glycolipid binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oligosaccharide binding	IBA Inferred from Biological aspect of Ancestor more info
enables oligosaccharide binding	IEA Inferred from Electronic Annotation more info
enables oligosaccharide binding	ISO Inferred from Sequence Orthology more info
enables oligosaccharide binding	ISS Inferred from Sequence or Structural Similarity more info
enables protease binding	IEA Inferred from Electronic Annotation more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables sialic acid binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukocyte tethering or rolling	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukocyte tethering or rolling	IEA Inferred from Electronic Annotation more info
involved_in leukocyte tethering or rolling	ISO Inferred from Sequence Orthology more info
involved_in leukocyte tethering or rolling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to ATP	ISO Inferred from Sequence Orthology more info
involved_in response to cytokine	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to hyperoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to linoleic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to oleic acid	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: L-selectin

Names: CD62 antigen-like family member L; LAM-1; LECAM1; leukocyte adhesion molecule 1; leukocyte-endothelial cell adhesion molecule 1; ly-22; lymph node homing receptor; lymphocyte antigen 22; lymphocyte surface MEL-14 antigen; selectin, lymphocyte

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019177.4 → NP_062050.3 L-selectin precursor

See identical proteins and their annotated locations for NP_062050.3

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

P30836

UniProtKB/TrEMBL

Q63762

Related

ENSRNOP00000089128.2, ENSRNOT00000106952.2

Conserved Domains (4) summary

cd00033
Location:197 → 255

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd03592
Location:39 → 157

CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)

PHA02817
Location:217 → 326

PHA02817; EEV Host range protein; Provisional

cd00054
Location:160 → 192

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

78950100..78969604

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039090616.2 → XP_038946544.1 L-selectin isoform X1

UniProtKB/TrEMBL

F7EY63

Related

ENSRNOP00000112528.1, ENSRNOT00000153927.1

Conserved Domains (4) summary

cd00033
Location:255 → 313

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd03592
Location:97 → 215

CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)

PHA02817
Location:275 → 384

PHA02817; EEV Host range protein; Provisional

cd00054
Location:218 → 250

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...