Myo1b myosin Ib [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Myo1bprovided by RGD
Official Full Name: myosin Ibprovided by RGD
Primary source: RGD:70994
See related: EnsemblRapid:ENSRNOG00000048152 AllianceGenome:RGD:70994
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MMIa; Myr1; MMI-alpha
Summary: Enables several functions, including actin filament binding activity; anion binding activity; and calmodulin binding activity. Involved in actin filament bundle assembly and actin filament-based movement. Located in several cellular components, including apical part of cell; brush border; and filopodium. Orthologous to human MYO1B (myosin IB). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 408.9), Liver (RPKM 370.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q22

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (57182059..57344335)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (49690043..49852373)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (54706005..54766054)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In pancreatic beta-cells myosin 1b regulates glucose-stimulated insulin secretion by modulating an early step in insulin granule trafficking from the Golgi.
Title: In pancreatic β-cells myosin 1b regulates glucose-stimulated insulin secretion by modulating an early step in insulin granule trafficking from the Golgi.
The C-terminal tail extension of myosin 16 acts as a molten globule, including intrinsically disordered regions, and interacts with the N-terminal ankyrin.
Title: The C-terminal tail extension of myosin 16 acts as a molten globule, including intrinsically disordered regions, and interacts with the N-terminal ankyrin.
expression of myosin 1b constructs influenced secretory vesicle compression rate in alveolar type II cells
Title: The role of myosin 1c and myosin 1b in surfactant exocytosis.
Binding of Myo1b to phosphoinositides plays an important role in vivo by regulating localization to actin-enriched membrane projections.[myosin 1b]
Title: Localization of myosin 1b to actin protrusions requires phosphoinositide binding.
Myo1b cross-links actin through a cryptic actin-binding site
Title: Mammalian class I myosin, Myo1b, is monomeric and cross-links actin filaments as determined by hydrodynamic studies and electron microscopy.
The biochemical rate constants that define the actomyo1b ATPase cycle at 37 degrees C and the temperature dependence of ATP binding, ADP release, and the transition from a nucleotide-inaccessible state to a nucleotide-accessible state were determined.
Title: Temperature dependence of nucleotide association and kinetic characterization of myo1b.
biochemical analysis of Myo1b splice isoforms
Title: Biochemical and motile properties of Myo1b splice isoforms.
Data suggest that loop 1 of Myo1b contributes to accessibility of the nucleotide pocket, is involved in integration of information from actin-, nucleotide-, gamma-P(i)-, and calmodulin-binding sites, and modulates load dependence of the motor.
Title: Loop 1 of transducer region in mammalian class I myosin, Myo1b, modulates actin affinity, ATPase activity, and nucleotide access.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	IDA Inferred from Direct Assay more info	PubMed
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microfilament motor activity	IDA Inferred from Direct Assay more info	PubMed
enables microfilament motor activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament bundle assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament-based movement	IDA Inferred from Direct Assay more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	NAS Non-traceable Author Statement more info	PubMed
involved_in post-Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within transferrin transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin filament	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
is_active_in brush border	IBA Inferred from Biological aspect of Ancestor more info
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in cluster of actin-based cell projections	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in filopodium	IDA Inferred from Direct Assay more info	PubMed
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: unconventional myosin-Ib

Names: myosin I alpha; myosin heavy chain myr 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001432365.1 → NP_001419294.1 unconventional myosin-Ib isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A8I6GGN1
NM_001432366.1 → NP_001419295.1 unconventional myosin-Ib isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A8I6GGN1, A0A8I6GLM5
NM_001432367.1 → NP_001419296.1 unconventional myosin-Ib isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A8I6GGN1, A0A8I6GLM5
NM_001432368.1 → NP_001419297.1 unconventional myosin-Ib isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A8I6GGN1
NM_001432369.1 → NP_001419298.1 unconventional myosin-Ib isoform 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A8I6G7W8, A0A8I6GGN1
NM_001432370.1 → NP_001419299.1 unconventional myosin-Ib isoform 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A8I6G7W8, A0A8I6GGN1
NM_053986.3 → NP_446438.1 unconventional myosin-Ib isoform 1

See identical proteins and their annotated locations for NP_446438.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

Q05096

UniProtKB/TrEMBL

A0A8I6GGN1

Related

ENSRNOP00000061523.3, ENSRNOT00000068433.5

Conserved Domains (3) summary

smart00015
Location:749 → 771

IQ; Calmodulin-binding motif

cd01378
Location:29 → 688

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:941 → 1118

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

57182059..57344335

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039082950.2 → XP_038938878.1 unconventional myosin-Ib isoform X1

UniProtKB/TrEMBL

A0A8I6GGN1

Related

ENSRNOP00000082803.2, ENSRNOT00000118845.2

Conserved Domains (3) summary

smart00015
Location:760 → 782

IQ; Calmodulin-binding motif

cd01378
Location:29 → 699

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:952 → 1129

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
XM_063266575.1 → XP_063122645.1 unconventional myosin-Ib isoform X2
XM_063266578.1 → XP_063122648.1 unconventional myosin-Ib isoform X5
XM_039082953.2 → XP_038938881.1 unconventional myosin-Ib isoform X7

Related

ENSRNOP00000095448.2, ENSRNOT00000108379.2

Conserved Domains (3) summary

smart00015
Location:749 → 771

IQ; Calmodulin-binding motif

cd01378
Location:29 → 688

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:912 → 1089

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
XM_039082955.2 → XP_038938883.1 unconventional myosin-Ib isoform X6

Conserved Domains (3) summary

smart00015
Location:749 → 771

IQ; Calmodulin-binding motif

cd01378
Location:29 → 688

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:883 → 1060

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
XM_063266574.1 → XP_063122644.1 unconventional myosin-Ib isoform X1

UniProtKB/TrEMBL

A0A8I6GGN1
XM_063266576.1 → XP_063122646.1 unconventional myosin-Ib isoform X3

UniProtKB/TrEMBL

A0A8I6GGN1
XM_063266577.1 → XP_063122647.1 unconventional myosin-Ib isoform X4

UniProtKB/TrEMBL

A0A8I6AFE5, A0A8I6GGN1

Related

ENSRNOP00000091336.1, ENSRNOT00000098464.2
XM_063266579.1 → XP_063122649.1 unconventional myosin-Ib isoform X8