Mpp4 MAGUK p55 scaffold protein 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mpp4provided by RGD
Official Full Name: MAGUK p55 scaffold protein 4provided by RGD
Primary source: RGD:620016
See related: EnsemblRapid:ENSRNOG00000010486 AllianceGenome:RGD:620016
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dlg6
Summary: Enables signaling receptor binding activity. Predicted to act upstream of or within protein localization to synapse. Predicted to be located in several cellular components, including cone cell pedicle; lateral plasma membrane; and rod spherule. Predicted to be part of protein-containing complex. Predicted to be active in adherens junction and plasma membrane. Orthologous to human MPP4 (MAGUK p55 scaffold protein 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 20.5), Lung (RPKM 5.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q31

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (68063867..68103050, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (60569734..60613035, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (65917917..65961274, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein localization to synapse	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in basal part of cell	ISO Inferred from Sequence Orthology more info
located_in cone cell pedicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in rod spherule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: MAGUK p55 subfamily member 4

Names: discs large homolog 6; membrane palmitoylated protein 4; membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4); rDLG6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021265.3 → NP_067088.2 MAGUK p55 subfamily member 4

See identical proteins and their annotated locations for NP_067088.2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A6IPA0

Related

ENSRNOP00000014094.8, ENSRNOT00000014094.9

Conserved Domains (6) summary

smart00569
Location:47 → 82

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12034
Location:245 → 305

SH3_MPP4; Src Homology 3 domain of Membrane Protein, Palmitoylated 4 (or MAGUK p55 subfamily member 4)

smart00072
Location:435 → 618

GuKc; Guanylate kinase homologues

cd00992
Location:152 → 231

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:427 → 617

Guanylate_kin; Guanylate kinase

pfam02828
Location:89 → 135

L27; L27 domain