Rab26 RAB26, member RAS oncogene family [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Rab26provided by RGD
Full Name: RAB26, member RAS oncogene familyprovided by RGD
Primary source: RGD:620890
See related: EnsemblRapid:ENSRNOG00000042086 AllianceGenome:RGD:620890
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables GTP binding activity. Involved in exocrine system development and regulation of exocytosis. Located in plasma membrane. Orthologous to human RAB26 (RAB26, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 109.0), Spleen (RPKM 25.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (14057942..14062602, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (13553395..13558063, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (13894271..13898578, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rab26 selectively directs synaptic and secretory vesicles into preautophagosomal structures.
Title: The GTPase Rab26 links synaptic vesicles to the autophagy pathway.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GMP binding	IEA Inferred from Electronic Annotation more info
enables GMP binding	ISO Inferred from Sequence Orthology more info
enables GMP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	TAS Traceable Author Statement more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane protein transport	IEA Inferred from Electronic Annotation more info
involved_in Golgi to plasma membrane protein transport	ISO Inferred from Sequence Orthology more info
involved_in Golgi to plasma membrane protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in exocrine system development	IDA Inferred from Direct Assay more info	PubMed
involved_in exocrine system development	IEA Inferred from Electronic Annotation more info
involved_in exocrine system development	ISO Inferred from Sequence Orthology more info
involved_in regulated exocytosis	IEA Inferred from Electronic Annotation more info
involved_in regulated exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulated exocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation protein catabolic process at presynapse	IEA Inferred from Electronic Annotation more info
involved_in regulation protein catabolic process at presynapse	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule membrane	ISO Inferred from Sequence Orthology more info
located_in secretory granule membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ras-related protein Rab-26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133580.2 → NP_598264.2 ras-related protein Rab-26

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

P51156, Q6P6W7

UniProtKB/TrEMBL

A6HCT9

Conserved Domains (1) summary

cd04112
Location:65 → 255

Rab26; Rab GTPase family 26 (Rab26)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

14057942..14062602 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085125.2 → XP_038941053.1 ras-related protein Rab-26 isoform X2

Conserved Domains (1) summary

cl38936
Location:65 → 302

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_039085122.2 → XP_038941050.1 ras-related protein Rab-26 isoform X1

Conserved Domains (1) summary

cl38936
Location:65 → 326

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_039085140.2 → XP_038941068.1 ras-related protein Rab-26 isoform X10

Conserved Domains (1) summary

cl38936
Location:65 → 139

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_039085128.2 → XP_038941056.1 ras-related protein Rab-26 isoform X3

Conserved Domains (1) summary

cl38936
Location:65 → 293

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_039085136.2 → XP_038941064.1 ras-related protein Rab-26 isoform X7

Conserved Domains (1) summary

cl38936
Location:65 → 242

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_039085134.2 → XP_038941062.1 ras-related protein Rab-26 isoform X5

Conserved Domains (1) summary

cl38936
Location:65 → 266

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_039085146.2 → XP_038941074.1 ras-related protein Rab-26 isoform X14

Conserved Domains (1) summary

cl38936
Location:65 → 168

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_039085138.2 → XP_038941066.1 ras-related protein Rab-26 isoform X9

Conserved Domains (1) summary

cl38936
Location:65 → 223

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_039085137.2 → XP_038941065.1 ras-related protein Rab-26 isoform X8

UniProtKB/TrEMBL

A0A8I5ZZI4

Related

ENSRNOP00000083203.1, ENSRNOT00000097378.2

Conserved Domains (1) summary

cd04112
Location:65 → 233

Rab26; Rab GTPase family 26 (Rab26)
XM_063268366.1 → XP_063124436.1 ras-related protein Rab-26 isoform X6

UniProtKB/TrEMBL

A0A8L2Q1F9

Related

ENSRNOP00000004249.5, ENSRNOT00000004249.8
XM_039085130.2 → XP_038941058.1 ras-related protein Rab-26 isoform X4

Related

ENSRNOP00000104150.1, ENSRNOT00000144497.1

Conserved Domains (1) summary

cd04112
Location:65 → 288

Rab26; Rab GTPase family 26 (Rab26)
XM_039085147.2 → XP_038941075.1 ras-related protein Rab-26 isoform X15

Conserved Domains (1) summary

cl38936
Location:65 → 139

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_039085144.2 → XP_038941072.1 ras-related protein Rab-26 isoform X12

Conserved Domains (1) summary

cl38936
Location:65 → 157

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_039085143.2 → XP_038941071.1 ras-related protein Rab-26 isoform X11

Conserved Domains (1) summary

cl38936
Location:65 → 139

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_039085145.2 → XP_038941073.1 ras-related protein Rab-26 isoform X13

Conserved Domains (1) summary

cl38936
Location:65 → 139

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_063268368.1 → XP_063124438.1 ras-related protein Rab-26 isoform X16