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    Gucy1a2 guanylate cyclase 1 soluble subunit alpha 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 66012, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gucy1a2provided by RGD
    Official Full Name
    guanylate cyclase 1 soluble subunit alpha 2provided by RGD
    Primary source
    RGD:621655
    See related
    EnsemblRapid:ENSRNOG00000029876 AllianceGenome:RGD:621655
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GCS-alpha-2
    Summary
    Enables guanylate cyclase activity. Predicted to be involved in cGMP-mediated signaling and response to oxygen levels. Predicted to act upstream of or within positive regulation of nitric oxide mediated signal transduction. Predicted to be located in cytosol. Predicted to be part of guanylate cyclase complex, soluble. Orthologous to human GUCY1A2 (guanylate cyclase 1 soluble subunit alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 273.0), Lung (RPKM 108.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gucy1a2 in Genome Data Viewer
    Location:
    8q11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (8785212..9174322)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (500212..900201)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (408001..899851)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene vomeronasal 2, receptor 116 like, pseudogene 31 Neighboring gene uncharacterized LOC120094355 Neighboring gene NSA2 ribosome biogenesis factor, pseudogene 14 Neighboring gene quinoid dihydropteridine reductase, pseudogene 1 Neighboring gene uncharacterized LOC103693002 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Impact of biological gender and soluble guanylate cyclase stimulation on renal recovery after relief of unilateral ureteral obstruction. Wang-Rosenke Y, et al. J Urol, 2012 Jul. PMID 22608751
    2. Cloning and functional expression of the rat alpha(2) subunit of soluble guanylyl cyclase. Koglin M, et al. Biochim Biophys Acta, 2000 Dec 1. PMID 11121588
    3. Expression of membrane-bound and cytosolic guanylyl cyclases in the rat inner ear. Seebacher T, et al. Hear Res, 1999 Jan. PMID 9925020
    4. The beta2 subunit inhibits stimulation of the alpha1/beta1 form of soluble guanylyl cyclase by nitric oxide. Potential relevance to regulation of blood pressure. Gupta G, et al. J Clin Invest, 1997 Sep 15. PMID 9294115, Free PMC Article
    5. Involvement of nNOS/NO/sGC/cGMP signaling pathway in cocaine sensitization and in the associated hippocampal alterations: does phosphodiesterase 5 inhibition help to drug vulnerability? Gabach LA, et al. Psychopharmacology (Berl), 2013 Sep. PMID 23579428

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Soluble guanylyl cyclase signal pathway is involved in the development of cocaine sensitization.
      Title: Involvement of nNOS/NO/sGC/cGMP signaling pathway in cocaine sensitization and in the associated hippocampal alterations: does phosphodiesterase 5 inhibition help to drug vulnerability?
    2. The effect of glucagon-like peptide-2 on the expression of the alpha1, alpha2, and beta1 subunits of soluble guanylyl cyclase, was studied.
      Title: Glucagon-like peptide-2 (GLP-2) modulates the cGMP signalling pathway by regulating the expression of the soluble guanylyl cyclase receptor subunits in cultured rat astrocytes.
    3. In each gender group alpha1 and beta1-soluble guanylate cyclase was comparably and significantly increased but female rats produced significantly more cyclic guanosine monophosphate after treatment with the soluble guanylate cyclase stimulator.
      Title: Impact of biological gender and soluble guanylate cyclase stimulation on renal recovery after relief of unilateral ureteral obstruction.
    4. Estradiol physiologically regulates sGC expression and activity in rat anterior pituitary gland.
      Title: Nitric oxide sensitive-guanylyl cyclase subunit expression changes during estrous cycle in anterior pituitary glands.
    5. Examine the involvement of soluble guanylate cyclase alpha(1) and alpha(2), and SK(Ca) channels in NANC relaxation of mouse distal colon.
      Title: Involvement of soluble guanylate cyclase alpha(1) and alpha(2), and SK(Ca) channels in NANC relaxation of mouse distal colon.
    6. studies indicated that stimulation of the NMDA receptor induces a downregulation in AUF1 levels stabilising the alpha2-guanylyl-cyclase mRNA transcripts.
      Title: NMDA induces post-transcriptional regulation of alpha2-guanylyl-cyclase-subunit expression in cerebellar granule cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cGMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nitric oxide mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of nitric oxide mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of nitric oxide mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of nitric oxide mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to oxygen levels IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of guanylate cyclase complex, soluble IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    guanylate cyclase soluble subunit alpha-2
    Names
    guanylate cyclase 1, soluble, alpha 2
    soluble guanylyl cyclase alpha2 subunit
    NP_076446.1
    XP_038938052.1
    XP_038938053.2
    XP_038938055.2
    XP_063122177.1
    XP_063122178.1
    XP_063122179.1
    XP_063122180.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023956.2 → NP_076446.1  guanylate cyclase soluble subunit alpha-2

      See identical proteins and their annotated locations for NP_076446.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q54A43, Q9WVI4
      UniProtKB/TrEMBL
      A6KQI9, Q8CH90
      Related
      ENSRNOP00000098928.1, ENSRNOT00000170498.1
      Conserved Domains (4) summary
      smart00044
      Location:483 → 672
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:512 → 696
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07700
      Location:157 → 268
      HNOB; Haem-NO-binding
      pfam07701
      Location:314 → 501
      HNOBA; Heme NO binding associated

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      8785212..9174322
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082127.2 → XP_038938055.2  guanylate cyclase soluble subunit alpha-2 isoform X2

      Related
      ENSRNOP00000040361.5, ENSRNOT00000046058.6

    2. XM_063266107.1 → XP_063122177.1  guanylate cyclase soluble subunit alpha-2 isoform X1

    3. XM_039082125.2 → XP_038938053.2  guanylate cyclase soluble subunit alpha-2 isoform X4

    4. XM_063266110.1 → XP_063122180.1  guanylate cyclase soluble subunit alpha-2 isoform X7

    5. XM_039082124.2 → XP_038938052.1  guanylate cyclase soluble subunit alpha-2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6AGA3
      Conserved Domains (2) summary
      pfam07700
      Location:157 → 268
      HNOB; Haem-NO-binding
      pfam07701
      Location:314 → 401
      HNOBA; Heme NO binding associated

    6. XM_063266108.1 → XP_063122178.1  guanylate cyclase soluble subunit alpha-2 isoform X3

    7. XM_063266109.1 → XP_063122179.1  guanylate cyclase soluble subunit alpha-2 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WVI4.2 GenPept UniProtKB/Swiss-Prot:Q9WVI4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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