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    Psme4 proteasome activator subunit 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498433, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Psme4provided by RGD
    Official Full Name
    proteasome activator subunit 4provided by RGD
    Primary source
    RGD:1591971
    See related
    EnsemblRapid:ENSRNOG00000060340 AllianceGenome:RGD:1591971
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable lysine-acetylated histone binding activity; peptidase activator activity; and proteasome binding activity. Predicted to be involved in DNA repair; proteasomal ubiquitin-independent protein catabolic process; and sperm DNA condensation. Predicted to be located in nucleoplasm. Predicted to be part of spermatoproteasome complex. Predicted to be active in cytosol and nucleus. Orthologous to human PSME4 (proteasome activator subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 515.3), Heart (RPKM 469.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Psme4 in Genome Data Viewer
    Location:
    14q22
    Exon count:
    51
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (108706643..108810330)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (104505716..104609410)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (115166165..115269041)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein K, pseudogene 5 Neighboring gene macrophage migration inhibitory factor, pseudogene 1 Neighboring gene G protein-coupled receptor 75 Neighboring gene endoplasmic reticulum lectin 1 Neighboring gene ankyrin repeat and SOCS box-containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis. Qian MX, et al. Cell, 2013 May 23. PMID 23706739, Free PMC Article
    2. Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins. Besche HC, et al. Biochemistry, 2009 Mar 24. PMID 19182904, Free PMC Article
    3. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lysine-acetylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysine-acetylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proteasome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasomal ubiquitin-independent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasomal ubiquitin-independent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sperm DNA condensation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spermatoproteasome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spermatoproteasome complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    proteasome activator complex subunit 4
    Names
    proteasome (prosome, macropain) activator subunit 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025140.2 → NP_001020311.2  proteasome activator complex subunit 4

      See identical proteins and their annotated locations for NP_001020311.2

      Status: VALIDATED

      Source sequence(s)
      AI763915, BC090326, CA339127, CA339363, CK600326, DN932843, DY314798, FM091221, JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A0G2K9R9, A0A8I6AIN2, A6JQD1
      Related
      ENSRNOP00000075103.2, ENSRNOT00000078329.3
      Conserved Domains (3) summary
      pfam11919
      Location:1757 → 1842
      DUF3437; Domain of unknown function (DUF3437)
      pfam16507
      Location:330 → 828
      BLM10_mid; Proteasome-substrate-size regulator, mid region
      sd00044
      Location:1571 → 1591
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      108706643..108810330
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008770467.4 → XP_008768689.2  proteasome activator complex subunit 4 isoform X1

      UniProtKB/TrEMBL
      A0A0G2KAX0, A0A8I6AIN2
      Related
      ENSRNOP00000075558.2, ENSRNOT00000088916.3
      Conserved Domains (3) summary
      sd00044
      Location:1593 → 1613
      HEAT; HEAT repeat [structural motif]
      pfam11919
      Location:1779 → 1864
      DUF3437; Domain of unknown function (DUF3437)
      pfam16507
      Location:352 → 850
      BLM10_mid; Proteasome-substrate-size regulator, mid region

    2. XM_039092328.2 → XP_038948256.1  proteasome activator complex subunit 4 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AIN2
      Conserved Domains (1) summary
      pfam16507
      Location:352 → 850
      BLM10_mid; Proteasome-substrate-size regulator, mid region

    3. XM_063273500.1 → XP_063129570.1  proteasome activator complex subunit 4 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AIN2

    4. XM_063273499.1 → XP_063129569.1  proteasome activator complex subunit 4 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AIN2

    5. XM_039092330.2 → XP_038948258.1  proteasome activator complex subunit 4 isoform X5

      UniProtKB/TrEMBL
      A6JQD0
      Conserved Domains (2) summary
      sd00044
      Location:729 → 749
      HEAT; HEAT repeat [structural motif]
      pfam11919
      Location:915 → 1000
      DUF3437; Domain of unknown function (DUF3437)

    6. XM_039092331.2 → XP_038948259.1  proteasome activator complex subunit 4 isoform X6

      UniProtKB/TrEMBL
      A6JQD0
      Conserved Domains (2) summary
      sd00044
      Location:652 → 672
      HEAT; HEAT repeat [structural motif]
      pfam11919
      Location:838 → 923
      DUF3437; Domain of unknown function (DUF3437)
    Nucleotide Protein Strain
    Heading Accession and Version

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