Homer1 homer scaffold protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Homer1provided by RGD
Official Full Name: homer scaffold protein 1provided by RGD
Primary source: RGD:628725
See related: EnsemblRapid:ENSRNOG00000047014 AllianceGenome:RGD:628725
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Vesl-1; HOMER1F
Summary: Enables several functions, including identical protein binding activity; scaffold protein binding activity; and type 5 metabotropic glutamate receptor binding activity. A structural constituent of postsynapse. Involved in several processes, including G protein-coupled glutamate receptor signaling pathway; protein tetramerization; and regulation of dendritic spine maintenance. Located in dendrite; excitatory synapse; and neuronal cell body. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human HOMER1 (homer scaffold protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 230.8), Muscle (RPKM 185.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (26279012..26388279)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (24542777..24645715)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (22909550..23012303)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kainic acid-induced status epilepticus decreases mGlu5 receptor and phase-specifically downregulates Homer1b/c expression.
Title: Kainic acid-induced status epilepticus decreases mGlu(5) receptor and phase-specifically downregulates Homer1b/c expression.
The Effects of Antipsychotics on the Synaptic Plasticity Gene Homer1a Depend on a Combination of Their Receptor Profile, Dose, Duration of Treatment, and Brain Regions Targeted.
Title: The Effects of Antipsychotics on the Synaptic Plasticity Gene Homer1a Depend on a Combination of Their Receptor Profile, Dose, Duration of Treatment, and Brain Regions Targeted.
Glutamatergic postsynaptic density in early life stress programming: Topographic gene expression of mGlu5 receptors and Homer proteins.
Title: Glutamatergic postsynaptic density in early life stress programming: Topographic gene expression of mGlu5 receptors and Homer proteins.
Homer1a protects against neuronal injury via PI3K/AKT/mTOR signaling pathway.
Title: Homer1a protects against neuronal injury via PI3K/AKT/mTOR signaling pathway.
We quantified the Homer1a (H1a) response of hippocampal neurons to systematically varied numbers of exposures to the same places by inducing male Long-Evans rats to run laps around a track.
Title: Immediate-early gene Homer1a intranuclear transcription focus intensity as a measure of relative neural activation.
Lysophosphatidic acid treatment did not alter the expression and distribution of Homer1 in cortical neurons. Knockdown of Homer1 using specific siRNA partially prevented the LPA-induced neurotoxicity and ER stress. LPA induced intracellular Ca(2+) release could be partly prevented by downregulation of Homer1.
Title: Homer1/mGluR1-mediated ER stress contributes to lysophosphatidic acid-induced neurotoxicity in cortical neurons.
Coimmunoprecipitation assays revealed the presence and interaction of all store-operated Ca(2+) influx channel components in the injured vascular smooth muscle cells, where Homer1 interacts with Orai1 and various TRPC channels.
Title: Homer binds to Orai1 and TRPC channels in the neointima and regulates vascular smooth muscle cell migration and proliferation.
These findings support a role of activity-induced Homer1 isoforms in learning and memory processes in discrete hippocampal subregions
Title: Hippocampal Regulation of Postsynaptic Density Homer1 by Associative Learning.
The Homer1 may anchor mGluR5 at presynaptic sites of cholinergic boutons at esophageal motor endplates, in a small subpopulation of VGLUT2-ir IGLEs and cholinergic varicosities within myenteric ganglia possibly modulating Ca(2+)-currents and neurotransmitter release.
Title: Homer1 (VesL-1) in the rat esophagus: focus on myenteric plexus and neuromuscular junction.
Homer1a serves as a molecular integrator of arousal and sleep need via the wake- and sleep-promoting neuromodulators, noradrenaline and adenosine, respectively.
Title: Homer1a drives homeostatic scaling-down of excitatory synapses during sleep.

Submit: New GeneRIF Correction See all GeneRIFs (73)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2Rat190 (e-PCR), detects polymorphism
- UniSTS:227353

Homer1 (e-PCR), detects polymorphism
- UniSTS:506984

D2Rat309 (e-PCR), detects polymorphism
- UniSTS:227443

D2Wox51 (e-PCR)
- UniSTS:240048

D2Wox53 (e-PCR)
- UniSTS:240050

BE119015 (e-PCR)
- UniSTS:249071

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled glutamate receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled glutamate receptor binding	IEA Inferred from Electronic Annotation more info
enables G protein-coupled glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables molecular adaptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of postsynapse	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables type 5 metabotropic glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled glutamate receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled glutamate receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in behavioral response to cocaine	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within behavioral response to cocaine	ISO Inferred from Sequence Orthology more info
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of calcium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in postsynapse organization	IEA Inferred from Electronic Annotation more info
involved_in protein localization to synapse	IDA Inferred from Direct Assay more info	PubMed
involved_in protein tetramerization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of calcium ion import	IEA Inferred from Electronic Annotation more info
involved_in regulation of calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in regulation of cation channel activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendritic spine maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dendritic spine maintenance	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of postsynaptic neurotransmitter receptor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of store-operated calcium entry	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of store-operated calcium entry	IEA Inferred from Electronic Annotation more info
involved_in regulation of store-operated calcium entry	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic transmission, glutamatergic	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in response to cocaine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nicotine	IEP Inferred from Expression Pattern more info	PubMed
involved_in skeletal muscle contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle fiber development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal muscle fiber development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Z disc	IEA Inferred from Electronic Annotation more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	IEA Inferred from Electronic Annotation more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in costamere	IEA Inferred from Electronic Annotation more info
located_in costamere	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic shaft	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in excitatory synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuron spine	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in postsynaptic cytosol	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic cytosol	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: homer protein homolog 1

Names: PSD-Zip45; VASP/Ena-related gene up-regulated during seizure and LTP 1; homer homolog 1; homer scaffolding protein 1; homer, neuronal immediate early gene, 1; scaffold protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031707.2 → NP_113895.1 homer protein homolog 1

See identical proteins and their annotated locations for NP_113895.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

O08567, O88800, Q9QUJ8, Q9QWN5, Q9Z214

UniProtKB/TrEMBL

A0A0H2UI35, A6I4T1

Related

ENSRNOP00000086769.2, ENSRNOT00000095790.2

Conserved Domains (2) summary

COG1196
Location:187 → 364

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01206
Location:3 → 111

EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

26279012..26388279

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006231775.5 → XP_006231837.1 homer protein homolog 1 isoform X1

See identical proteins and their annotated locations for XP_006231837.1

UniProtKB/TrEMBL

A0A0H2UI35, A6I4T3

Conserved Domains (3) summary

cd01206
Location:3 → 111

EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

cl12013
Location:167 → 333

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl19219
Location:248 → 318

DUF342; Protein of unknown function (DUF342)
XM_039102105.2 → XP_038958033.1 homer protein homolog 1 isoform X2

UniProtKB/TrEMBL

A0A8I5ZMY0, A6I4U0, A6I4U1

Related

ENSRNOP00000079557.2, ENSRNOT00000104734.2

Conserved Domains (1) summary

cd01206
Location:3 → 111

EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain