Oat ornithine aminotransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Oatprovided by RGD
Official Full Name: ornithine aminotransferaseprovided by RGD
Primary source: RGD:621724
See related: EnsemblRapid:ENSRNOG00000016807 AllianceGenome:RGD:621724
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: rOAT
Summary: Predicted to enable identical protein binding activity; ornithine aminotransferase activity; and pyridoxal phosphate binding activity. Predicted to be involved in arginine catabolic process to glutamate and arginine catabolic process to proline via ornithine. Predicted to be located in mitochondrial matrix and nucleoplasm. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in gyrate atrophy. Orthologous to human OAT (ornithine aminotransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 4521.5), Liver (RPKM 1062.7) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (196777973..196797754, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (187347862..187367644, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (204562289..204582070, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The portacaval shunt caused a marked decrease in glutamine synthetase activity and an increase in ornithine aminotransferase activity.
Title: The effect of portacaval anastomosis on the expression of glutamine synthetase and ornithine aminotransferase in perivenous hepatocytes.
Almost all OAT protein was localized in cortical and medullary proximal straight tubules and in proximal straight tubule, Arginase II protein distribution overlapped that of OAT
Title: Ornithine metabolism in male and female rat kidney: mitochondrial expression of ornithine aminotransferase and arginase II.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127469 (e-PCR)
- UniSTS:210779

D1Bda37 (e-PCR)
- UniSTS:239784

RH139534 (e-PCR)
- UniSTS:221620

RH140369 (e-PCR)
- UniSTS:222445

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity	TAS Traceable Author Statement more info	PubMed
enables identical protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables ornithine aminotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ornithine aminotransferase activity	ISO Inferred from Sequence Orthology more info
enables ornithine aminotransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables pyridoxal phosphate binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in L-proline biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in arginine catabolic process to glutamate	IBA Inferred from Biological aspect of Ancestor more info
involved_in arginine catabolic process to proline via ornithine	IBA Inferred from Biological aspect of Ancestor more info
involved_in ornithine metabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ornithine aminotransferase, mitochondrial

Names: ornithine aminotransferase (gyrate atrophy); ornithine--oxo-acid aminotransferase

NP_071966.1

EC 2.6.1.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.