Ung uracil-DNA glycosylase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ungprovided by RGD
Official Full Name: uracil-DNA glycosylaseprovided by RGD
Primary source: RGD:1307200
See related: AllianceGenome:RGD:1307200
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables uracil DNA N-glycosylase activity. Involved in base-excision repair and negative regulation of apoptotic process. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in dysgammaglobulinemia and immunodeficiency with hyper IgM type 5. Orthologous to human UNG (uracil DNA glycosylase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 105.3), Kidney (RPKM 99.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (48145838..48154789, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (42485276..42494217, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (48246593..48255547, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

NoName (e-PCR)
- UniSTS:235272

RH134515 (e-PCR)
- UniSTS:217795

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables damaged DNA binding	ISO Inferred from Sequence Orthology more info
enables ribosomal small subunit binding	ISO Inferred from Sequence Orthology more info
enables uracil DNA N-glycosylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables uracil DNA N-glycosylase activity	IDA Inferred from Direct Assay more info	PubMed
enables uracil DNA N-glycosylase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA repair	TAS Traceable Author Statement more info	PubMed
involved_in base-excision repair	IDA Inferred from Direct Assay more info	PubMed
involved_in base-excision repair	ISO Inferred from Sequence Orthology more info
involved_in base-excision repair	TAS Traceable Author Statement more info	PubMed
involved_in base-excision repair, AP site formation via deaminated base removal	IBA Inferred from Biological aspect of Ancestor more info
involved_in base-excision repair, AP site formation via deaminated base removal	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within isotype switching	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somatic hypermutation of immunoglobulin genes	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within somatic recombination of immunoglobulin gene segments	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: uracil-DNA glycosylase

NP_001013142.1

EC 3.2.2.27

XP_008767558.2

EC 3.2.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013124.1 → NP_001013142.1 uracil-DNA glycosylase

See identical proteins and their annotated locations for NP_001013142.1

Status: PROVISIONAL

Source sequence(s)

BC091211

UniProtKB/TrEMBL

F7F2G1, Q5BK44

Conserved Domains (1) summary

TIGR00628
Location:86 → 295

ung; uracil-DNA glycosylase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

48145838..48154789 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008769336.4 → XP_008767558.2 uracil-DNA glycosylase isoform X1

UniProtKB/TrEMBL

A0A8J8YLI4, A6J209

Conserved Domains (2) summary

TIGR00628
Location:93 → 302

ung; uracil-DNA glycosylase

cd10027
Location:149 → 153

UDG-F1-like; motif A [structural motif]