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    Avp arginine vasopressin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24221, updated on 27-Dec-2024

    Summary

    Official Symbol
    Avpprovided by RGD
    Official Full Name
    arginine vasopressinprovided by RGD
    Primary source
    RGD:2184
    See related
    EnsemblRapid:ENSRNOG00000021229 AllianceGenome:RGD:2184
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    DI; VP; ADH; Vas
    Summary
    Enables V1A vasopressin receptor binding activity; V1B vasopressin receptor binding activity; and neuropeptide hormone activity. Involved in several processes, including grooming behavior; maternal aggressive behavior; and maternal behavior. Located in dendrite; extracellular space; and secretory granule. Is active in neuronal dense core vesicle. Used to study diabetes insipidus; hyperglycemia; portal hypertension; temporal lobe epilepsy; and type 1 diabetes mellitus. Biomarker of alcohol use disorder; hypertension; neurohypophyseal diabetes insipidus; type 2 diabetes mellitus; and vascular dementia. Human ortholog(s) of this gene implicated in diabetes insipidus and neurohypophyseal diabetes insipidus. Orthologous to human AVP (arginine vasopressin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 24.5) and Testes (RPKM 3.9) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Avp in Genome Data Viewer
    Location:
    3q36
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (138246544..138248522, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (117793447..117805091, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (123117482..123119460, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S26 Neighboring gene oxytocin/neurophysin I prepropeptide Neighboring gene U-box domain containing 5 Neighboring gene FAST kinase domains 5 Neighboring gene leucine zipper tumor suppressor family member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables V1A vasopressin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables V1A vasopressin receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables V1A vasopressin receptor binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables V1A vasopressin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables V1B vasopressin receptor binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables V2 vasopressin receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    enables neurohypophyseal hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables neuropeptide hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables neuropeptide hormone activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables neuropeptide hormone activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in grooming behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in maternal aggressive behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in maternal behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in multicellular organismal-level water homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of female receptivity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transmission of nerve impulse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cellular pH reduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glutamate secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of prostaglandin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of systemic arterial blood pressure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of vasoconstriction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to nicotine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to testosterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in social behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in symbiont entry into host cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in temperature homeostasis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuronal dense core vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    vasopressin-neurophysin 2-copeptin
    Names
    AVP-NPII
    antidiuretic hormone
    arginine vasopressin (Diabetes insipidus), same as Di (conflicting physical mapping)
    prepropressophysin
    preprovasopressin-neurophysin
    vasopressin
    vasopressin-neurophysin prepropeptide

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016992.2NP_058688.2  vasopressin-neurophysin 2-copeptin preproprotein

      See identical proteins and their annotated locations for NP_058688.2

      Status: VALIDATED

      Source sequence(s)
      M25646
      UniProtKB/Swiss-Prot
      P01186
      UniProtKB/TrEMBL
      A6HQA1
      Related
      ENSRNOP00000028833.2, ENSRNOT00000028833.7
      Conserved Domains (1) summary
      smart00003
      Location:43120
      NH; Neurohypophysial hormones

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      138246544..138248522 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)