Afap1l2 actin filament associated protein 1-like 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Afap1l2provided by RGD
Official Full Name: actin filament associated protein 1-like 2provided by RGD
Primary source: RGD:1310668
See related: EnsemblRapid:ENSRNOG00000017164 AllianceGenome:RGD:1310668
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1310668
Summary: Predicted to enable SH2 domain binding activity; SH3 domain binding activity; and protein tyrosine kinase activator activity. Predicted to be involved in several processes, including positive regulation of epidermal growth factor receptor signaling pathway; regulation of gene expression; and regulation of mitotic cell cycle. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol. Orthologous to human AFAP1L2 (actin filament associated protein 1 like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 87.9), Kidney (RPKM 62.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q55

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (265969368..266065951, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (255964238..256060828, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (277730760..277827299, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Estradiol up-regulates Cav1.2alpha1C and ICa,L via plasma membrane ER and by activating Pi3K, Akt, and CREB signaling. The promoter regions of the CACNA1C gene (human-rabbit-rat) contain adjacent/overlapping binding sites for p-CREB and ERalpha, which suggests a synergistic regulation by these pathways.
Title: Estradiol up-regulates L-type Ca(2+) channels via membrane-bound estrogen receptor/phosphoinositide-3-kinase/Akt/cAMP response element-binding protein signaling pathway.
cAMP-dependent induction of PI3KAP/XB130, which is associated with PI3K, is required for enhancement of IGF mitogenic activities. [PI3KAP]
Title: Phosphatidylinositol 3-kinase-binding protein, PI3KAP/XB130, is required for cAMP-induced amplification of IGF mitogenic activity in FRTL-5 thyroid cells.
XB130 is a Rac-controlled component of lamellipodia that regulates cell motility and invasion.
Title: Adaptor protein XB130 is a Rac-controlled component of lamellipodia that regulates cell motility and invasion.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH2 domain binding	ISO Inferred from Sequence Orthology more info
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: actin filament-associated protein 1-like 2

Names: phosphatidylinositol 3-kinase-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001305184.1 → NP_001292113.1 actin filament-associated protein 1-like 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

F1M5W8, M0R484

Related

ENSRNOP00000064164.3, ENSRNOT00000073346.5

Conserved Domains (3) summary

cd13306
Location:184 → 290

PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1

cd13307
Location:372 → 472

PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2

pfam00169
Location:190 → 289

PH; PH domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

265969368..266065951 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063282799.1 → XP_063138869.1 actin filament-associated protein 1-like 2 isoform X2
XM_008760580.4 → XP_008758802.1 actin filament-associated protein 1-like 2 isoform X1

See identical proteins and their annotated locations for XP_008758802.1

UniProtKB/TrEMBL

F1M5W8

Conserved Domains (3) summary

cd13306
Location:212 → 318

PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1

cd13307
Location:400 → 500

PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2

pfam00169
Location:218 → 317

PH; PH domain
XM_063282804.1 → XP_063138874.1 actin filament-associated protein 1-like 2 isoform X8
XM_063282800.1 → XP_063138870.1 actin filament-associated protein 1-like 2 isoform X4
XM_063282803.1 → XP_063138873.1 actin filament-associated protein 1-like 2 isoform X7
XM_063282802.1 → XP_063138872.1 actin filament-associated protein 1-like 2 isoform X6
XM_017588861.3 → XP_017444350.1 actin filament-associated protein 1-like 2 isoform X3

UniProtKB/TrEMBL

A0A8I6ARV2, F1M5W8

Conserved Domains (3) summary

cd13306
Location:212 → 318

PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1

cd13307
Location:400 → 500

PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2

pfam00169
Location:218 → 317

PH; PH domain
XM_063282801.1 → XP_063138871.1 actin filament-associated protein 1-like 2 isoform X5

UniProtKB/TrEMBL

A0A8I5ZTP6

Related

ENSRNOP00000097019.2, ENSRNOT00000110011.2
XM_063282805.1 → XP_063138875.1 actin filament-associated protein 1-like 2 isoform X9

Related

ENSRNOP00000023113.6, ENSRNOT00000023113.9