Fxyd6 FXYD domain-containing ion transport regulator 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fxyd6provided by RGD
Official Full Name: FXYD domain-containing ion transport regulator 6provided by RGD
Primary source: RGD:69315
See related: AllianceGenome:RGD:69315
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Php
Summary: This reference sequence was derived from multiple replicate ESTs and a deposited cDNA, and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD6, is novel and has not been characterized as a protein. The name "phosphohippolin" has been used in GenBank, but there is no evidence yet of protein phosphorylation. [RefSeq curation by Kathleen J. Sweadner, Ph.D., [email protected]., Dec 2000]
Expression: Biased expression in Kidney (RPKM 223.0), Adrenal (RPKM 200.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q22

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (54575578..54602715)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (45679054..45705958)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (49676520..49703419)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FXYD6 is expressed in the inner ear and may have a role in endolymph homeostasis and neuronal activity
Title: Dynamic expression of FXYD6 in the inner ear suggests a role of the protein in endolymph homeostasis and neuronal activity.
findings suggest that Php may play an important role in the excitability of neurons in the central nervous system during postnatal development, as well as those in the adult brain
Title: Phosphohippolin expression in the rat central nervous system.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ion channel regulator activity	IEA Inferred from Electronic Annotation more info
enables sodium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in positive regulation of sodium ion export across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: FXYD domain-containing ion transport regulator 6

Names: VESP6; phosphohippolin; vascular endothelial cell-specific protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022005.3 → NP_071288.1 FXYD domain-containing ion transport regulator 6 precursor

See identical proteins and their annotated locations for NP_071288.1

Status: REVIEWED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

Q91XV6, Q9JLR4

UniProtKB/TrEMBL

A6J439

Conserved Domains (1) summary

cl40453
Location:2 → 93

FXYD; phenylalanine-X-tyrosine-aspartate (FXYD) family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

54575578..54602715

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008766171.4 → XP_008764393.1 FXYD domain-containing ion transport regulator 6 isoform X1

UniProtKB/Swiss-Prot

Q91XV6

Conserved Domains (1) summary

cl40453
Location:2 → 92

FXYD; phenylalanine-X-tyrosine-aspartate (FXYD) family