Kcnk1 potassium two pore domain channel subfamily K member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnk1provided by RGD
Official Full Name: potassium two pore domain channel subfamily K member 1provided by RGD
Primary source: RGD:621447
See related: EnsemblRapid:ENSRNOG00000019937 AllianceGenome:RGD:621447
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Twik
Summary: Enables potassium ion leak channel activity and sodium channel activity. Involved in cellular response to acidic pH; potassium ion transmembrane transport; and response to nicotine. Located in apical plasma membrane and brush border membrane. Orthologous to human KCNK1 (potassium two pore domain channel subfamily K member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 140.4), Kidney (RPKM 78.6) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (70856985..70895053)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (53959411..53997726)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (58823836..58862926)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TET1 overexpression attenuates paclitaxel-induced neuropathic pain through rescuing K2p1.1 expression in primary sensory neurons of male rats.
Title: TET1 overexpression attenuates paclitaxel-induced neuropathic pain through rescuing K(2p)1.1 expression in primary sensory neurons of male rats.
K(2P)1.1 (TWIK 1) immunoreactivity was detected along nerve terminals, supporting cells and blood vessels of the crista ampullaris and in the cytoplasm of neurons of the Scarpa's ganglia. K(2P)2.1
Title: Distribution of two-pore-domain potassium channels in the adult rat vestibular periphery.
multiple TASK currents were present in a DRG nociceptor and differentially contributed to distinct discharge mechanisms.
Title: Characterization and function of TWIK-related acid sensing K+ channels in a rat nociceptive cell.
TASK-1 mRNA is present in ventrolateral medulla neurons that regulate respiration or circulation (C1 adrenergic neurons). TASK channels are expressed by respiratory cells with putative rhythmogenic function and by premotor and motor neurons.
Title: Cardiorespiratory neurons of the rat ventrolateral medulla contain TASK-1 and TASK-3 channel mRNA.

Submit: New GeneRIF Correction

General gene information

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Markers

RH129028 (e-PCR)
- UniSTS:212336

BE097296 (e-PCR)
- UniSTS:244634

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables inward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables ligand-gated channel activity	ISO Inferred from Sequence Orthology more info
enables ligand-gated channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables potassium channel activity	ISO Inferred from Sequence Orthology more info
enables potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables potassium ion leak channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium ion leak channel activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium ion leak channel activity	ISO Inferred from Sequence Orthology more info
enables potassium ion leak channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables sodium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium channel activity	ISO Inferred from Sequence Orthology more info
enables sodium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info
NOT enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to acidic pH	IDA Inferred from Direct Assay more info	PubMed
involved_in chloride transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in chloride transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in glutamate secretion	ISO Inferred from Sequence Orthology more info
involved_in glutamate secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of resting membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of resting membrane potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to nicotine	IEP Inferred from Expression Pattern more info	PubMed
involved_in sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
part_of inward rectifier potassium channel complex	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of potassium channel complex	ISO Inferred from Sequence Orthology more info
part_of potassium channel complex	ISS Inferred from Sequence or Structural Similarity more info
located_in recycling endosome	IEA Inferred from Electronic Annotation more info
located_in synaptic membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: potassium channel subfamily K member 1

Names: inward rectifying potassium channel protein TWIK-1; potassium channel K2P1; potassium channel, subfamily K, member 1; potassium channel, two pore domain subfamily K, member 1; putative potassium channel TWIK; rTWIK

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021688.3 → NP_067720.1 potassium channel subfamily K member 1

See identical proteins and their annotated locations for NP_067720.1

Status: VALIDATED

Source sequence(s)

BC061807, JAXUCZ010000019

UniProtKB/Swiss-Prot

Q9Z2T2

UniProtKB/TrEMBL

A6KJ44

Related

ENSRNOP00000027058.3, ENSRNOT00000027058.7

Conserved Domains (1) summary

pfam07885
Location:101 → 157

Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

70856985..70895053

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063278268.1 → XP_063134338.1 potassium channel subfamily K member 1 isoform X3
XM_039097960.2 → XP_038953888.1 potassium channel subfamily K member 1 isoform X1

Conserved Domains (1) summary

pfam07885
Location:139 → 214

Ion_trans_2; Ion channel
XM_006255820.5 → XP_006255882.1 potassium channel subfamily K member 1 isoform X2

Conserved Domains (1) summary

pfam07885
Location:126 → 202

Ion_trans_2; Ion channel