Wif1 Wnt inhibitory factor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Wif1provided by RGD
Official Full Name: Wnt inhibitory factor 1provided by RGD
Primary source: RGD:619774
See related: EnsemblRapid:ENSRNOG00000004476 AllianceGenome:RGD:619774
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable activin receptor binding activity and nodal binding activity. Predicted to be involved in circulatory system development; nodal signaling pathway; and regionalization. Predicted to act upstream of or within positive regulation of fat cell differentiation. Predicted to be active in cell surface and extracellular region. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and urinary bladder cancer. Orthologous to human WIF1 (WNT inhibitory factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 367.7), Spleen (RPKM 30.3) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (58433326..58503853)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (56548060..56618364)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (63094955..63165158)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that microRNA miR-17-5p over-expression promoted the activation of hepatic stellate cell (HSC) and contributed to the reduction of Wnt inhibitory factor 1 (WIF1) levels.
Title: MicroRNA-17-5p-activated Wnt/β-catenin pathway contributes to the progression of liver fibrosis.
downregulation of Smad1/Wif1 gene expression may contribute to pulmonary hypoplasia in the nitrofen CDH model by retardation of lung development during saccular stage.
Title: Smad1 and WIF1 genes are downregulated during saccular stage of lung development in the nitrofen rat model.
Wif-1 inhibits proliferation of neoplastic choroid plexus epithelial cells
Title: Role of Wnt inhibitory factor-1 and Wnt/wingless signaling in choroid plexus tumors.
GLT mRNA was translated in Wnt-1-expressing C6 cells when the GLT mRNA required no splicing before translation occurred
Title: Wnt-1 has multiple effects on the expression of glutamate transporters.

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General gene information

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Markers

Wif1 (e-PCR), detects polymorphism
- UniSTS:527127

D7Got45 (e-PCR)
- UniSTS:114016

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within positive regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: wnt inhibitory factor 1

Names: WIF-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399510.1 → NP_001386439.1 wnt inhibitory factor 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

Q6IN38, Q924Y6

UniProtKB/TrEMBL

A6IGZ2, A6IGZ3

Related

ENSRNOP00000006426.4, ENSRNOT00000006426.7

Conserved Domains (1) summary

cl02623
Location:35 → 179

WIF; WIF domain