Cnbp CCHC-type zinc finger, nucleic acid binding protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cnbpprovided by RGD
Official Full Name: CCHC-type zinc finger, nucleic acid binding proteinprovided by RGD
Primary source: RGD:621807
See related: EnsemblRapid:ENSRNOG00000010239 AllianceGenome:RGD:621807
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Znf9; Cnbp1
Summary: Enables single-stranded DNA binding activity and single-stranded RNA binding activity. Predicted to be involved in several processes, including G-quadruplex DNA formation; positive regulation of cytoplasmic translation; and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; endoplasmic reticulum; and nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in myotonic dystrophy type 2. Orthologous to human CNBP (CCHC-type zinc finger nucleic acid binding protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 3356.9), Heart (RPKM 2167.4) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 4q34

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (121860102..121868976, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (120302768..120311694, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (119747890..119756787, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings showed that ZNF9 is ubiquitously expressed in mammalian tissues, and that its signal is not substantially modified in myotonic dystrophy type 2 muscles
Title: The myotonic dystrophy type 2 (DM2) gene product zinc finger protein 9 (ZNF9) is associated with sarcomeres and normally localized in DM2 patients' muscles.
Znf9 haploinsufficiency contributes to the myotonic dystrophy phenotype in Znf9+/- mice.
Title: Haploinsuffciency for Znf9 in Znf9+/- mice is associated with multiorgan abnormalities resembling myotonic dystrophy.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

RH132805 (e-PCR)
- UniSTS:216088

RH124749 (e-PCR)
- UniSTS:161571

Cnbp (e-PCR), detects polymorphism
- UniSTS:141362

UniSTS:224585 (e-PCR)
- UniSTS:224585

PMC15869P1 (e-PCR)
- UniSTS:271437

SHGC-77307 (e-PCR)
- UniSTS:25935

Cnbp (e-PCR), detects polymorphism
- UniSTS:547432

Cnbp (e-PCR), detects polymorphism
- UniSTS:479151

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G-quadruplex DNA binding	IEA Inferred from Electronic Annotation more info
enables G-quadruplex DNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables single-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables translation regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G-quadruplex DNA formation	IEA Inferred from Electronic Annotation more info
involved_in G-quadruplex DNA formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
NOT located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
NOT located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Go to the top of the page Help

Preferred Names: CCHC-type zinc finger nucleic acid binding protein

Names: cellular nucleic acid binding protein 1; cellular nucleic acid-binding protein; zinc finger protein 9 (a cellular retroviral nucleic acid binding protein)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022598.1 → NP_072120.1 CCHC-type zinc finger nucleic acid binding protein

See identical proteins and their annotated locations for NP_072120.1

Status: PROVISIONAL

Source sequence(s)

D45254

UniProtKB/Swiss-Prot

P62634, Q5QJQ8

UniProtKB/TrEMBL

A6IB27

Conserved Domains (1) summary

PTZ00368
Location:54 → 171

PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

121860102..121868976 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006236854.5 → XP_006236916.1 CCHC-type zinc finger nucleic acid binding protein isoform X3

See identical proteins and their annotated locations for XP_006236916.1

UniProtKB/TrEMBL

A6IB26

Related

ENSRNOP00000013884.7, ENSRNOT00000013884.8

Conserved Domains (1) summary

PTZ00368
Location:47 → 164

PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
XM_017592879.3 → XP_017448368.1 CCHC-type zinc finger nucleic acid binding protein isoform X2

Conserved Domains (1) summary

PTZ00368
Location:47 → 165

PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
XM_017592878.3 → XP_017448367.1 CCHC-type zinc finger nucleic acid binding protein isoform X1

UniProtKB/TrEMBL

A0A8L2Q6G7

Conserved Domains (1) summary

PTZ00368
Location:54 → 172

PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional