Lef1 lymphoid enhancer binding factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lef1provided by MGI
Official Full Name: lymphoid enhancer binding factor 1provided by MGI
Primary source: MGI:MGI:96770
See related: Ensembl:ENSMUSG00000027985 AllianceGenome:MGI:96770
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lef-1; 3000002B05
Summary: Enables DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and chromatin binding activity. Involved in several processes, including T-helper 1 cell differentiation; positive regulation of cell differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including blood vessel morphogenesis; brain development; and embryonic morphogenesis. Located in cytoplasm and nucleus. Part of beta-catenin-TCF complex. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to human LEF1 (lymphoid enhancer binding factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in thymus adult (RPKM 63.3), spleen adult (RPKM 14.2) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 G3; 3 60.78 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (130903972..131018006)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (131110297..131224357)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of TCF7 and LEF1 is a key determinant of tumor-infiltrating regulatory T-cell function.
Title: Downregulation of TCF7 and LEF1 is a key determinant of tumor-infiltrating regulatory T-cell function.
LEF1 isoforms regulate cellular senescence and aging.
Title: LEF1 isoforms regulate cellular senescence and aging.
TCF7 and LEF-1 downregulation in sepsis promotes immune suppression by inhibiting CD4[+] T cell proliferation.
Title: TCF7 and LEF-1 downregulation in sepsis promotes immune suppression by inhibiting CD4(+) T cell proliferation.
PD1 is transcriptionally regulated by LEF1 in mature T cells.
Title: PD1 is transcriptionally regulated by LEF1 in mature T cells.
The Chromatin Regulator Mll1 Supports T Follicular Helper Cell Differentiation by Controlling Expression of Bcl6, LEF-1, and TCF-1.
Title: The Chromatin Regulator Mll1 Supports T Follicular Helper Cell Differentiation by Controlling Expression of Bcl6, LEF-1, and TCF-1.
Expression dynamics of lymphoid enhancer-binding factor 1 in terminal Schwann cells, dermal papilla, and interfollicular epidermis.
Title: Expression dynamics of lymphoid enhancer-binding factor 1 in terminal Schwann cells, dermal papilla, and interfollicular epidermis.
miR-34a Regulates Lipid Droplet Deposition in 3T3-L1 and C2C12 Cells by Targeting LEF1.
Title: miR-34a Regulates Lipid Droplet Deposition in 3T3-L1 and C2C12 Cells by Targeting LEF1.
Oncogenic and Tumor Suppressor Functions for Lymphoid Enhancer Factor 1 in E2a(-/-) T Acute Lymphoblastic Leukemia.
Title: Oncogenic and Tumor Suppressor Functions for Lymphoid Enhancer Factor 1 in E2a(-/-) T Acute Lymphoblastic Leukemia.
TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state.
Title: TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state.
A beta-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells.
Title: A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells.

Submit: New GeneRIF Correction See all GeneRIFs (89)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234825

Lef1 (e-PCR), detects polymorphism
- UniSTS:464714

X58636 (e-PCR)
- UniSTS:125808

Lef1 (e-PCR), detects polymorphism
- UniSTS:507018

Lef1 (e-PCR), detects polymorphism
- UniSTS:499097

AI451430 (e-PCR)
- UniSTS:165297

D3Mit290 (e-PCR), detects polymorphism
- UniSTS:129721

Lef1 (e-PCR), detects polymorphism
- UniSTS:207060

Lef1 (e-PCR), detects polymorphism
- UniSTS:508397

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables C2H2 zinc finger domain binding	IEA Inferred from Electronic Annotation more info
enables C2H2 zinc finger domain binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding, bending	EXP Inferred from Experiment more info	PubMed
enables DNA binding, bending	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IGI Inferred from Genetic Interaction more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables armadillo repeat domain binding	IEA Inferred from Electronic Annotation more info
enables armadillo repeat domain binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	IEA Inferred from Electronic Annotation more info
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables gamma-catenin binding	IEA Inferred from Electronic Annotation more info
enables gamma-catenin binding	ISO Inferred from Sequence Orthology more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables nuclear estrogen receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	EXP Inferred from Experiment more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor binding	ISO Inferred from Sequence Orthology more info
enables transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription regulator inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within T cell receptor V(D)J recombination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in T-helper 1 cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within alpha-beta T cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within anatomical structure regression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within apoptotic process involved in blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within apoptotic process involved in morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching involved in blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-4	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interleukin-4	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chorio-allantoic fusion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dentate gyrus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic limb morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within epithelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within face morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within forebrain neuroblast division	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within forebrain radial glial cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within formation of radial glial scaffolds	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hippocampus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mammary gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA binding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process in bone marrow cell	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process in bone marrow cell	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-13 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-13 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-4 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-4 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-5 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-5 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of striated muscle tissue development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in neutrophil differentiation	IEA Inferred from Electronic Annotation more info
involved_in neutrophil differentiation	ISO Inferred from Sequence Orthology more info
involved_in odontoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osteoblast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within paraxial mesoderm formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation by host of viral transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation by host of viral transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell cycle process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell proliferation in bone marrow	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell proliferation in bone marrow	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of chondrocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gamma-delta T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of granulocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of granulocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of odontoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein localization to chromatin	IEA Inferred from Electronic Annotation more info
involved_in protein localization to chromatin	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurogenesis	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in secondary palate development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of taste	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somitogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tongue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within trachea gland development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed
part_of beta-catenin-TCF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of beta-catenin-TCF complex	IDA Inferred from Direct Assay more info	PubMed
part_of beta-catenin-TCF complex	ISO Inferred from Sequence Orthology more info
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-DNA complex	IEA Inferred from Electronic Annotation more info
part_of protein-DNA complex	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lymphoid enhancer-binding factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001276402.2 → NP_001263331.1 lymphoid enhancer-binding factor 1 isoform b

See identical proteins and their annotated locations for NP_001263331.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the internal coding region and lacks an exon in the 3' coding region which results in the use of a downstream stop codon, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.

Source sequence(s)

AC114668, AC123634

Consensus CDS

CCDS71319.1

UniProtKB/TrEMBL

Q8BGZ9

Related

ENSMUSP00000101948.3, ENSMUST00000106341.9

Conserved Domains (2) summary

cd01388
Location:268 → 339

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam08347
Location:1 → 211

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001276403.1 → NP_001263332.1 lymphoid enhancer-binding factor 1 isoform c

See identical proteins and their annotated locations for NP_001263332.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate 5' exon and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) is shorter and has a distinct N-terminus, compared to isoform a.

Source sequence(s)

AC114668, AK028246, AK083328, BE632124

Consensus CDS

CCDS71320.1

UniProtKB/TrEMBL

Q8C402

Related

ENSMUSP00000096211.4, ENSMUST00000098611.4

Conserved Domains (2) summary

cd01388
Location:230 → 301

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam08347
Location:1 → 145

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001379059.1 → NP_001365988.1 lymphoid enhancer-binding factor 1 isoform d

Status: VALIDATED

Source sequence(s)

AC114668, AC123634

Conserved Domains (2) summary

cd01388
Location:296 → 367

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:1 → 211

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001379060.1 → NP_001365989.1 lymphoid enhancer-binding factor 1 isoform e

Status: VALIDATED

Source sequence(s)

AC114668, AC123634

UniProtKB/TrEMBL

D3Z654

Related

ENSMUSP00000067808.7, ENSMUST00000066849.13

Conserved Domains (2) summary

cd01388
Location:268 → 339

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:1 → 211

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001379061.1 → NP_001365990.1 lymphoid enhancer-binding factor 1 isoform f

Status: VALIDATED

Source sequence(s)

AC114668, AC123634

Conserved Domains (2) summary

cd01388
Location:202 → 273

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:2 → 145

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001379062.1 → NP_001365991.1 lymphoid enhancer-binding factor 1 isoform g

Status: VALIDATED

Source sequence(s)

AC123634

Conserved Domains (2) summary

cd01388
Location:115 → 186

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:1 → 30

CTNNB1_binding; N-terminal CTNNB1 binding
NM_010703.5 → NP_034833.2 lymphoid enhancer-binding factor 1 isoform a

See identical proteins and their annotated locations for NP_034833.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript.

Source sequence(s)

AC114668, AC123634

Consensus CDS

CCDS17842.1

UniProtKB/Swiss-Prot

P27782

UniProtKB/TrEMBL

Q3TYB0

Related

ENSMUSP00000029611.8, ENSMUST00000029611.14

Conserved Domains (2) summary

cd01388
Location:296 → 367

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam08347
Location:1 → 211

CTNNB1_binding; N-terminal CTNNB1 binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

130903972..131018006

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030252440.2 → XP_030108300.1 lymphoid enhancer-binding factor 1 isoform X2

Conserved Domains (2) summary

cd01388
Location:202 → 273

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:2 → 145

CTNNB1_binding; N-terminal CTNNB1 binding
XM_006501070.4 → XP_006501133.1 lymphoid enhancer-binding factor 1 isoform X1

Conserved Domains (2) summary

cd01388
Location:230 → 301

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:2 → 145

CTNNB1_binding; N-terminal CTNNB1 binding
XM_036162910.1 → XP_036018803.1 lymphoid enhancer-binding factor 1 isoform X3

Conserved Domains (2) summary

cd01388
Location:87 → 158

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:1 → 30

CTNNB1_binding; N-terminal CTNNB1 binding
XM_036162911.1 → XP_036018804.1 lymphoid enhancer-binding factor 1 isoform X4

Conserved Domains (2) summary

cd01388
Location:115 → 186

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:1 → 30

CTNNB1_binding; N-terminal CTNNB1 binding