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    FCGR1BP Fc gamma receptor Ib, pseudogene [ Homo sapiens (human) ]

    Gene ID: 2210, updated on 10-Dec-2024

    Summary

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    Official Symbol
    FCGR1BPprovided by HGNC
    Official Full Name
    Fc gamma receptor Ib, pseudogeneprovided by HGNC
    Primary source
    HGNC:HGNC:3614
    See related
    Ensembl:ENSG00000291135 MIM:601502; AllianceGenome:HGNC:3614
    Gene type
    pseudo
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD34; FCG1; FcRI; CD64b; FCGR1; IGFR1; IGFRB; FCGR1B; FcgammaRIa
    Summary
    Three distinct, but closely related classes of receptors that bind the Fc portion of IgG have been identified (Fcgamma RI, II and III). The FcgammaRI family consists of three closely related genes termed A, B, and C. This gene likely encodes a non-functional protein that is not detectable at the cell surface and binds ligand with low affinity. [provided by RefSeq, Nov 2019]
    Expression
    Biased expression in appendix (RPKM 11.2), placenta (RPKM 7.0) and 11 other tissues See more
    Orthologs
    all
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    Genomic context

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    See FCGR1BP in Genome Data Viewer
    Location:
    1p11.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (121087345..121097161)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (121096728..121106544)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (120926128..120935944, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PDE4DIP pseudogene 4 Neighboring gene tRNA-Asn (anticodon GTT) 27-1 Neighboring gene ubiquitin-conjugating enzyme E2 D4-like Neighboring gene H3 histone pseudogene 4 Neighboring gene uncharacterized LOC100996318 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1254 Neighboring gene H2B histone pseudogene 1 Neighboring gene ribosomal protein L22 pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. [Diagnostic value of FCGR1B gene transcription level in active tuberculosis]. Liu YH, et al. Zhonghua Jie He He Hu Xi Za Zhi, 2022 Apr 12. PMID 35381635
    2. The alternatively spliced CD64 transcript FcgammaRIb2 does not specify a surface-expressed isoform. van Vugt MJ, et al. Eur J Immunol, 1999 Jan. PMID 9933095
    3. [Study on mutations of beta chain of high-affinity IgE receptor gene in people of Han nationality of southern China]. Tang Y, et al. Zhonghua Jie He He Hu Xi Za Zhi, 2001 Mar. PMID 11802953
    4. The monocyte transcriptome during pregnancy in multiple sclerosis: prominent expression of the Fc-receptor CD64. Neuteboom RF, et al. Mult Scler, 2011 Apr. PMID 21135020
    5. Up-regulation of CD64 Expression on Monocytes in Patients With Active Adult-Onset Still Disease: A Possible Biomarker of Disease Activity. Shimizu T, et al. J Clin Rheumatol, 2020 Mar. PMID 32073518

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [Diagnostic value of FCGR1B gene transcription level in active tuberculosis].
      Title: [Diagnostic value of FCGR1B gene transcription level in active tuberculosis].
    2. Up-regulation of CD64 Expression on Monocytes in Patients With Active Adult-Onset Still Disease: A Possible Biomarker of Disease Activity.
      Title: Up-regulation of CD64 Expression on Monocytes in Patients With Active Adult-Onset Still Disease: A Possible Biomarker of Disease Activity.
    3. The increased CD64 expression during pregnancy in patients with multiple sclerosis is indicative of enhanced innate immune functions.
      Title: The monocyte transcriptome during pregnancy in multiple sclerosis: prominent expression of the Fc-receptor CD64.
    4. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: [Study on mutations of beta chain of high-affinity IgE receptor gene in people of Han nationality of southern China].
    6. Fcgamma receptor I Ab and Fcgamma receptor I play an important role in the regulation of alopecia areata (AA), are useful for a marker of the disease prognosis and are worth intense research for the reasonable and specific therapy of AA.
      Title: Serum anti-Fcgamma receptor autoantibodies in patients with alopecia areata.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env IgG2 and IgG4 bind more poorly to enzymatically deglycosylated recombinant gp120 (rgp120) than to unchanged rgp120 PubMed
    Nef nef HIV-1 Nef downregulates Fc-gamma Receptor I in human monocytes/macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Other Names

    • Fc fragment of IgG receptor Ib
    • Fc fragment of IgG, high affinity Ib, receptor (CD64)
    • Fc gamma receptor Ib
    • Fc-gamma RI
    • Fc-gamma RIA
    • Fc-gamma receptor I B2
    • High affinity immunoglobulin gamma Fc receptor I
    • IgG Fc receptor I
    • fc-gamma RIB
    • fcRIB
    • hFcgammaRIB
    • high affinity immunoglobulin gamma Fc receptor IB
    • igG Fc receptor IB

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables IgG binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables IgG binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables IgG receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables immunoglobulin receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Fc-gamma receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in antibody-dependent cellular cytotoxicity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of phagocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of tumor necrosis factor production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in clathrin-coated endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in early endosome membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_045213.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an additional exon compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC244453

    2. NR_164758.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC244453
      Related
      ENST00000369383.10

    3. NR_164759.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC244453
      Related
      ENST00000369384.11

    4. NR_164760.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC244453
      Related
      ENST00000471609.3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      121087345..121097161
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      121096728..121106544
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_030319.1: Suppressed sequence

      Description
      NG_030319.1: This RefSeq was removed because it is now thought that this gene is a pseudogene.

    2. NM_001004340.4: Suppressed sequence

      Description
      NM_001004340.4: This RefSeq was removed because it is now thought that this gene is a pseudogene.

    3. NM_001017986.4: Suppressed sequence

      Description
      NM_001017986.4: This RefSeq was removed because it is now thought that this gene is a pseudogene.

    4. NM_001244910.1: Suppressed sequence

      Description
      NM_001244910.1: This RefSeq was removed because it is now thought that this gene is a pseudogene.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q92637.1 GenPept UniProtKB/Swiss-Prot:Q92637

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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