ADAM22 ADAM metallopeptidase domain 22 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ADAM22provided by HGNC
Official Full Name: ADAM metallopeptidase domain 22provided by HGNC
Primary source: HGNC:HGNC:201
See related: Ensembl:ENSG00000008277 MIM:603709; AllianceGenome:HGNC:201
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MDC2; DEE61; EIEE61; ADAM 22
Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]
Expression: Biased expression in brain (RPKM 9.0), adrenal (RPKM 2.5) and 10 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q21.12

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (87934251..88202889)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (89184170..89453378)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (87563566..87832204)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ADAM22 acts as a novel predictive biomarker for unfavorable prognosis and facilitates metastasis via PI3K/AKT signaling pathway in nasopharyngeal carcinoma.
Title: ADAM22 acts as a novel predictive biomarker for unfavorable prognosis and facilitates metastasis via PI3K/AKT signaling pathway in nasopharyngeal carcinoma.
Biallelic ADAM22 pathogenic variants cause progressive encephalopathy and infantile-onset refractory epilepsy.
Title: Biallelic ADAM22 pathogenic variants cause progressive encephalopathy and infantile-onset refractory epilepsy.
LGI3 is secreted and binds to ADAM22 via TRIF-dependent NF-kappaB pathway in response to LPS in human keratinocytes.
Title: LGI3 is secreted and binds to ADAM22 via TRIF-dependent NF-κB pathway in response to LPS in human keratinocytes.
ADAM22/LGI1 complex as a new actionable target for breast cancer brain metastasis.
Title: ADAM22/LGI1 complex as a new actionable target for breast cancer brain metastasis.
the LGI1-ADAM22 complex functions as the trans-synaptic machinery for precise synaptic transmission
Title: Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM22.
ADAM22 is critically involved in miR-449a-reduced tamoxifen resistance of estrogen receptor-positive breast cancer cells as a direct target of miR-449a.
Title: miR-449a Suppresses Tamoxifen Resistance in Human Breast Cancer Cells by Targeting ADAM22.
these results support the existence of a second mechanism, alternative to inhibition of protein secretion, by which ADLTE-causing LGI1 mutations exert their loss-of-function effect extracellularly, and suggest that interactions of LGI1 with both ADAM22 and ADAM23 play an important role in the molecular mechanisms leading to utosomal dominant lateral temporal epilepsy
Title: Secretion-Positive LGI1 Mutations Linked to Lateral Temporal Epilepsy Impair Binding to ADAM22 and ADAM23 Receptors.
Disruption of LGI1-ADAM22 interaction reduces synaptic AMPA receptors in hippocampal neurons.
Title: Autoantibodies to epilepsy-related LGI1 in limbic encephalitis neutralize LGI1-ADAM22 interaction and reduce synaptic AMPA receptors.
Data suggest that ADAM22 plays roles in cell differentiation, cell migration, and resistance to endocrine therapy in breast cancer; ADAM22 may serve as biomarker for poor disease-free survival in breast cancer patients. [REVIEW]
Title: ADAM22 as a prognostic and therapeutic drug target in the treatment of endocrine-resistant breast cancer.
findings suggest that SRC-1 switches steroid-responsive tumors to a steroid-resistant state in which the SRC-1 target gene ADAM22 has a critical role
Title: Global characterization of the SRC-1 transcriptome identifies ADAM22 as an ER-independent mediator of endocrine-resistant breast cancer.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Developmental and epileptic encephalopathy, 61 MedGen: C4693688 OMIM: 617933 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
Genome-wide association study of serious blistering skin rash caused by drugs. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH120576 (e-PCR)
- UniSTS:132409

RH93001 (e-PCR)
- UniSTS:87103

RH119592 (e-PCR)
- UniSTS:132675

SHGC-79053 (e-PCR)
- UniSTS:95877

D7S1543 (e-PCR)
- UniSTS:44423

A002T31 (e-PCR)
- UniSTS:68755

RH92490 (e-PCR)
- UniSTS:86944

STS-N29801 (e-PCR)
- UniSTS:22180

G42258 (e-PCR)
- UniSTS:93361

ADAM22_1746 (e-PCR)
- UniSTS:276966

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables integrin binding	NAS Non-traceable Author Statement more info	PubMed
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in central nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of cell adhesion	NAS Non-traceable Author Statement more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: disintegrin and metalloproteinase domain-containing protein 22

Names: a disintegrin and metalloproteinase domain 22; metalloproteinase-disintegrin ADAM22-3; metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001324417.2 → NP_001311346.1 disintegrin and metalloproteinase domain-containing protein 22 isoform 6 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (6) encodes isoform 6. The encoded isoform (6) may undergo proteolytic processing.

Source sequence(s)

AC004992, AC005075, AC005164, DR000609, R41888

UniProtKB/TrEMBL

Q08AL8
NM_001324418.2 → NP_001311347.1 disintegrin and metalloproteinase domain-containing protein 22 isoform 7 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (7) encodes isoform 7. The encoded isoform (7) may undergo proteolytic processing.

Source sequence(s)

AC004992, AC005075, AC005164, DR000609, R41888

Consensus CDS

CCDS94137.1

UniProtKB/TrEMBL

A0A804HHS1, H7C3I4

Related

ENSP00000412085.2, ENST00000413139.2
NM_001324419.2 → NP_001311348.1 disintegrin and metalloproteinase domain-containing protein 22 isoform 8 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (8) encodes isoform 8. The encoded isoform (8) may undergo proteolytic processing.

Source sequence(s)

AC004992, AC005075, AC005164, DR000609, R41888

UniProtKB/TrEMBL

A0A804HHS1
NM_001324420.2 → NP_001311349.1 disintegrin and metalloproteinase domain-containing protein 22 isoform 9 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (9) encodes isoform 9. The encoded isoform (9) may undergo proteolytic processing.

Source sequence(s)

AC004992, AC005075, AC005164, DR000609, R41888

UniProtKB/TrEMBL

A0A804HHS1
NM_001324421.2 → NP_001311350.1 disintegrin and metalloproteinase domain-containing protein 22 isoform 10 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (10) encodes isoform 10. The encoded isoform (10) may undergo proteolytic processing.

Source sequence(s)

AC004992, AC005075, AC005164, DR000609, R41888

UniProtKB/TrEMBL

Q08AL8
NM_001391975.1 → NP_001378904.1 disintegrin and metalloproteinase domain-containing protein 22 isoform 11 precursor

Status: REVIEWED

Source sequence(s)

AC004992, AC005075, AC005164

UniProtKB/TrEMBL

Q08AL8

Conserved Domains (4) summary

smart00050
Location:470 → 545

DISIN; Homologues of snake disintegrins

smart00608
Location:547 → 688

ACR; ADAM Cysteine-Rich Domain

pfam01421
Location:256 → 455

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:102 → 205

Pep_M12B_propep; Reprolysin family propeptide
NM_001391976.1 → NP_001378905.1 disintegrin and metalloproteinase domain-containing protein 22 isoform 12 precursor

Status: REVIEWED

Source sequence(s)

AC004992, AC005075, AC005164

UniProtKB/TrEMBL

Q08AL8

Conserved Domains (4) summary

smart00050
Location:453 → 528

DISIN; Homologues of snake disintegrins

smart00608
Location:530 → 671

ACR; ADAM Cysteine-Rich Domain

pfam01421
Location:239 → 438

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:71 → 188

Pep_M12B_propep; Reprolysin family propeptide
NM_001391977.1 → NP_001378906.1 disintegrin and metalloproteinase domain-containing protein 22 isoform 13 precursor

Status: REVIEWED

Source sequence(s)

AC004992, AC005075, AC005164

UniProtKB/TrEMBL

Q08AL8

Conserved Domains (4) summary

smart00050
Location:453 → 528

DISIN; Homologues of snake disintegrins

smart00608
Location:530 → 671

ACR; ADAM Cysteine-Rich Domain

pfam01421
Location:239 → 438

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:71 → 188

Pep_M12B_propep; Reprolysin family propeptide
NM_001391978.1 → NP_001378907.1 disintegrin and metalloproteinase domain-containing protein 22 isoform 14 precursor

Status: REVIEWED

Source sequence(s)

AC004992, AC005075, AC005164

UniProtKB/TrEMBL

Q08AL8

Conserved Domains (4) summary

smart00050
Location:452 → 527

DISIN; Homologues of snake disintegrins

smart00608
Location:529 → 670

ACR; ADAM Cysteine-Rich Domain

pfam01421
Location:238 → 437

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:70 → 187

Pep_M12B_propep; Reprolysin family propeptide
NM_001391979.1 → NP_001378908.1 disintegrin and metalloproteinase domain-containing protein 22 isoform 15 precursor

Status: REVIEWED

Source sequence(s)

AC004992, AC005075, AC005164

UniProtKB/TrEMBL

Q08AL8

Conserved Domains (4) summary

smart00050
Location:452 → 527

DISIN; Homologues of snake disintegrins

smart00608
Location:529 → 670

ACR; ADAM Cysteine-Rich Domain

pfam01421
Location:238 → 437

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:70 → 187

Pep_M12B_propep; Reprolysin family propeptide
NM_001391980.1 → NP_001378909.1 disintegrin and metalloproteinase domain-containing protein 22 isoform 16 precursor

Status: REVIEWED

Source sequence(s)

AC004992, AC005075, AC005164

UniProtKB/TrEMBL

Q08AL8

Conserved Domains (4) summary

smart00050
Location:470 → 545

DISIN; Homologues of snake disintegrins

smart00608
Location:547 → 688

ACR; ADAM Cysteine-Rich Domain

pfam01421
Location:256 → 455

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:102 → 205

Pep_M12B_propep; Reprolysin family propeptide
NM_001391981.1 → NP_001378910.1 disintegrin and metalloproteinase domain-containing protein 22 isoform 17 precursor

Status: REVIEWED

Source sequence(s)

AC004992, AC005075, AC005164

UniProtKB/TrEMBL

Q08AL8

Conserved Domains (4) summary

smart00050
Location:452 → 527

DISIN; Homologues of snake disintegrins

smart00608
Location:529 → 670

ACR; ADAM Cysteine-Rich Domain

pfam01421
Location:238 → 437

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:70 → 187

Pep_M12B_propep; Reprolysin family propeptide
NM_001391982.1 → NP_001378911.1 disintegrin and metalloproteinase domain-containing protein 22 isoform 18 precursor

Status: REVIEWED

Source sequence(s)

AC004992, AC005075, AC005164

UniProtKB/TrEMBL

Q08AL8

Conserved Domains (4) summary

smart00050
Location:445 → 520

DISIN; Homologues of snake disintegrins

smart00608
Location:522 → 663

ACR; ADAM Cysteine-Rich Domain

pfam01421
Location:241 → 430

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:102 → 205

Pep_M12B_propep; Reprolysin family propeptide
NM_004194.5 → NP_004185.1 disintegrin and metalloproteinase domain-containing protein 22 isoform 4 precursor

See identical proteins and their annotated locations for NP_004185.1

Status: REVIEWED

Description

Transcript Variant: This variant (4), also known as beta, uses an alternate splice site in the 3' coding region and lacks two downstream exons, compared to variant 1. The resulting protein (isoform 4) has a shorter and distinct C-terminus, compared to isoform 1. The encoded isoform (4) may undergo proteolytic processing.

Source sequence(s)

AB009671, AC005075, DR000609

Consensus CDS

CCDS43610.1

UniProtKB/TrEMBL

A0A804HHS1

Related

ENSP00000381260.4, ENST00000398201.8

Conserved Domains (5) summary

smart00608
Location:530 → 671

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:239 → 436

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam00200
Location:453 → 527

Disintegrin; Disintegrin

pfam01421
Location:239 → 438

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:75 → 187

Pep_M12B_propep; Reprolysin family propeptide
NM_016351.6 → NP_057435.2 disintegrin and metalloproteinase domain-containing protein 22 isoform 3 precursor

See identical proteins and their annotated locations for NP_057435.2

Status: REVIEWED

Description

Transcript Variant: This variant (3), also known as alpha, lacks an in-frame exon compared to variant 1. The encoded isoform (3) is shorter than isoform 1. The encoded isoform (3) may undergo proteolytic processing.

Source sequence(s)

AC005075, AC005164, AK291010, DR000609, R41888

Consensus CDS

CCDS43609.1

UniProtKB/TrEMBL

Q08AL8

Related

ENSP00000381262.4, ENST00000398204.8

Conserved Domains (5) summary

smart00608
Location:530 → 671

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:239 → 436

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam00200
Location:453 → 527

Disintegrin; Disintegrin

pfam01421
Location:239 → 438

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:75 → 187

Pep_M12B_propep; Reprolysin family propeptide
NM_021721.5 → NP_068367.1 disintegrin and metalloproteinase domain-containing protein 22 isoform 5 precursor

See identical proteins and their annotated locations for NP_068367.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses an alternate splice site in the 3' coding region and lacks one coding and two non-coding exons, compared to variant 1. The resulting protein (isoform 5) has a shorter and distinct C-terminus, compared to isoform 1. The encoded isoform (5) may undergo proteolytic processing.

Source sequence(s)

AB009671, AC005075, AF155381, DR000609

Consensus CDS

CCDS94138.1

UniProtKB/TrEMBL

Q08AL8

Related

ENSP00000508320.1, ENST00000684002.1

Conserved Domains (5) summary

smart00608
Location:530 → 671

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:239 → 436

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam00200
Location:453 → 527

Disintegrin; Disintegrin

pfam01421
Location:239 → 438

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:75 → 187

Pep_M12B_propep; Reprolysin family propeptide
NM_021722.6 → NP_068368.2 disintegrin and metalloproteinase domain-containing protein 22 isoform 2 precursor

See identical proteins and their annotated locations for NP_068368.2

Status: REVIEWED

Description

Transcript Variant: This variant (2), also known as delta, has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. The encoded isoform (2) may undergo proteolytic processing.

Source sequence(s)

AC005075, AF155381, DR000609, R41888

Consensus CDS

CCDS43608.1

UniProtKB/TrEMBL

Q08AL8

Related

ENSP00000381267.3, ENST00000398209.7

Conserved Domains (5) summary

smart00608
Location:530 → 671

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:239 → 436

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam00200
Location:453 → 527

Disintegrin; Disintegrin

pfam01421
Location:239 → 438

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:75 → 187

Pep_M12B_propep; Reprolysin family propeptide
NM_021723.5 → NP_068369.1 disintegrin and metalloproteinase domain-containing protein 22 isoform 1 preproprotein

See identical proteins and their annotated locations for NP_068369.1

Status: REVIEWED

Description

Transcript Variant: This variant (1), also known as epsilon, encodes isoform 1, which is proteolytically processed to generate the mature protein.

Source sequence(s)

AC005075, AF155382, DR000609, R41888

Consensus CDS

CCDS47637.1

UniProtKB/Swiss-Prot

O75075, O75076, Q9P0K1, Q9P0K2, Q9UIA1, Q9UKK2

UniProtKB/TrEMBL

Q08AL8

Related

ENSP00000265727.7, ENST00000265727.11

Conserved Domains (5) summary

smart00608
Location:530 → 671

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:239 → 436

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam00200
Location:453 → 527

Disintegrin; Disintegrin

pfam01421
Location:239 → 438

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:75 → 187

Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

87934251..88202889

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017012330.3 → XP_016867819.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X9

UniProtKB/TrEMBL

A0A804HHS1
XM_017012335.3 → XP_016867824.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X14

UniProtKB/TrEMBL

Q08AL8
XM_011516318.3 → XP_011514620.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X2

UniProtKB/TrEMBL

A0A804HHS1

Conserved Domains (5) summary

smart00608
Location:530 → 671

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:239 → 436

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam00200
Location:453 → 527

Disintegrin; Disintegrin

pfam01421
Location:239 → 438

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:75 → 187

Pep_M12B_propep; Reprolysin family propeptide
XM_011516322.3 → XP_011514624.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X7

UniProtKB/TrEMBL

Q08AL8

Conserved Domains (5) summary

smart00608
Location:530 → 671

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:239 → 436

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam00200
Location:453 → 527

Disintegrin; Disintegrin

pfam01421
Location:239 → 438

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:75 → 187

Pep_M12B_propep; Reprolysin family propeptide
XM_017012332.3 → XP_016867821.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X11

UniProtKB/TrEMBL

Q08AL8
XM_017012333.3 → XP_016867822.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X13

UniProtKB/TrEMBL

A0A804HHS1
XM_011516323.3 → XP_011514625.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X10

UniProtKB/TrEMBL

Q08AL8

Conserved Domains (5) summary

smart00608
Location:530 → 671

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:239 → 436

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam00200
Location:453 → 527

Disintegrin; Disintegrin

pfam01421
Location:239 → 438

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:75 → 187

Pep_M12B_propep; Reprolysin family propeptide
XM_011516319.4 → XP_011514621.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X3

UniProtKB/TrEMBL

A0A804HHS1

Conserved Domains (5) summary

smart00608
Location:529 → 670

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:238 → 435

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam00200
Location:452 → 526

Disintegrin; Disintegrin

pfam01421
Location:238 → 437

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:74 → 186

Pep_M12B_propep; Reprolysin family propeptide
XM_006716028.5 → XP_006716091.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X1

UniProtKB/TrEMBL

B3KWN4

Conserved Domains (5) summary

smart00608
Location:582 → 723

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:291 → 488

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam00200
Location:505 → 579

Disintegrin; Disintegrin

pfam01421
Location:291 → 490

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:127 → 239

Pep_M12B_propep; Reprolysin family propeptide
XM_011516320.4 → XP_011514622.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X4

UniProtKB/TrEMBL

B3KWN4

Conserved Domains (5) summary

smart00608
Location:582 → 723

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:291 → 488

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam00200
Location:505 → 579

Disintegrin; Disintegrin

pfam01421
Location:291 → 490

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:127 → 239

Pep_M12B_propep; Reprolysin family propeptide
XM_011516321.4 → XP_011514623.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X5

UniProtKB/TrEMBL

B3KWN4

Conserved Domains (5) summary

smart00608
Location:582 → 723

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:291 → 488

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam00200
Location:505 → 579

Disintegrin; Disintegrin

pfam01421
Location:291 → 490

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:127 → 239

Pep_M12B_propep; Reprolysin family propeptide
XM_005250445.5 → XP_005250502.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X8

UniProtKB/TrEMBL

B3KWN4

Conserved Domains (5) summary

smart00608
Location:582 → 723

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:291 → 488

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam00200
Location:505 → 579

Disintegrin; Disintegrin

pfam01421
Location:291 → 490

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:127 → 239

Pep_M12B_propep; Reprolysin family propeptide
XM_006716029.5 → XP_006716092.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X6

UniProtKB/TrEMBL

B3KWN4

Conserved Domains (5) summary

smart00608
Location:582 → 723

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:291 → 488

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam00200
Location:505 → 579

Disintegrin; Disintegrin

pfam01421
Location:291 → 490

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:127 → 239

Pep_M12B_propep; Reprolysin family propeptide
XM_011516324.3 → XP_011514626.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X12

UniProtKB/TrEMBL

A0A804HHS1

Conserved Domains (5) summary

smart00608
Location:456 → 597

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:165 → 362

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam00200
Location:379 → 453

Disintegrin; Disintegrin

pfam01421
Location:165 → 364

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:8 → 113

Pep_M12B_propep; Reprolysin family propeptide

Alternate T2T-CHM13v2.0

Genomic

NC_060931.1 Alternate T2T-CHM13v2.0

Range

89184170..89453378

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054358425.1 → XP_054214400.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X9

UniProtKB/TrEMBL

A0A804HHS1
XM_054358430.1 → XP_054214405.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X14

UniProtKB/TrEMBL

Q08AL8
XM_054358418.1 → XP_054214393.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X2

UniProtKB/TrEMBL

A0A804HHS1
XM_054358423.1 → XP_054214398.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X7

UniProtKB/TrEMBL

Q08AL8
XM_054358427.1 → XP_054214402.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X11

UniProtKB/TrEMBL

Q08AL8
XM_054358429.1 → XP_054214404.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X13

UniProtKB/TrEMBL

A0A804HHS1
XM_054358426.1 → XP_054214401.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X10

UniProtKB/TrEMBL

Q08AL8
XM_054358419.1 → XP_054214394.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X3

UniProtKB/TrEMBL

A0A804HHS1
XM_054358417.1 → XP_054214392.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X1

UniProtKB/TrEMBL

B3KWN4
XM_054358420.1 → XP_054214395.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X4

UniProtKB/TrEMBL

B3KWN4
XM_054358421.1 → XP_054214396.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X5

UniProtKB/TrEMBL

B3KWN4
XM_054358424.1 → XP_054214399.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X8

UniProtKB/TrEMBL

B3KWN4
XM_054358422.1 → XP_054214397.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X6

UniProtKB/TrEMBL

B3KWN4
XM_054358428.1 → XP_054214403.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X12

UniProtKB/TrEMBL

A0A804HHS1