Icam2 intercellular adhesion molecule 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Icam2provided by MGI
Official Full Name: intercellular adhesion molecule 2provided by MGI
Primary source: MGI:MGI:96394
See related: Ensembl:ENSMUSG00000001029 AllianceGenome:MGI:96394
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD102; Ly-60; Icam-2
Summary: Predicted to enable integrin binding activity. Predicted to be involved in cell adhesion. Located in microvillus; plasma membrane; and uropod. Is expressed in cardiovascular system; central nervous system; extraembryonic component; female reproductive system; and retina. Orthologous to human ICAM2 (intercellular adhesion molecule 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in lung adult (RPKM 101.8), thymus adult (RPKM 40.1) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E1; 11 69.09 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (106268482..106278948, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (106377656..106388139, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ICAM2 is related to good prognosis in dendritic cell immunotherapy for cancer.
Title: ICAM2 is related to good prognosis in dendritic cell immunotherapy for cancer.
Data show that intercellular adhesion molecule 1 (ICAM-1) and ICAM-2 on B cells are essential for long-lasting cognate T follicular helper (Tfh)-B cell interactions and efficient selection of low-affinity B cell clones for proliferative clonal expansion.
Title: ICAMs support B cell interactions with T follicular helper cells and promote clonal selection.
These results indicate that, whereas T cells use ICAM-1 and -2 for temporary pulmonary entrapment, neutrophils get sequestered and extravasate into inflamed lungs independent of ICAMs.
Title: Lung ICAM-1 and ICAM-2 support spontaneous intravascular effector lymphocyte entrapment but are not required for neutrophil entrapment or emigration inside endotoxin-inflamed lungs.
Results indicate that the interaction of ICAM-2 with alpha-actinin is critical to conferring an ICAM-2-mediated non-metastatic phenotype in neuroblastoma cells.
Title: ICAM-2 confers a non-metastatic phenotype in neuroblastoma cells by interaction with α-actinin.
ICAM-2 regulates endothelial barrier function and permeability through a pathway involving N-Cadherin, ERMs and Rac-1
Title: ICAM-2 regulates vascular permeability and N-cadherin localization through ezrin-radixin-moesin (ERM) proteins and Rac-1 signalling.
These findings highlight novel roles for ICAM-2 in mediating luminal neutrophil crawling and the effect on subsequent levels of extravasation.
Title: ICAM-2 facilitates luminal interactions between neutrophils and endothelial cells in vivo.
beta2 integrin-mediated neutrophil crawling on endothelial ICAM-1 and ICAM-2 is a prerequisite for transcellular neutrophil diapedesis across the inflamed BBB.
Title: β2 integrin-mediated crawling on endothelial ICAM-1 and ICAM-2 is a prerequisite for transcellular neutrophil diapedesis across the inflamed blood-brain barrier.
a sequential involvement of endothelial ICAM-1 and VCAM-1 in mediating shear-resistant T cell arrest, followed by endothelial ICAM-1 and ICAM-2 in mediating T cell crawling to sites permissive for diapedesis across BBB endothelium.
Title: Differential roles for endothelial ICAM-1, ICAM-2, and VCAM-1 in shear-resistant T cell arrest, polarization, and directed crawling on blood-brain barrier endothelium.
unique role for ICAM-1 in intraluminal lymphocyte crawling but redundant roles for ICAM-1 and ICAM-2 in lymphocyte diapedesis and interstitial motility
Title: Comprehensive analysis of lymph node stroma-expressed Ig superfamily members reveals redundant and nonredundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing.
show that the sequential expression of CD40 and Icam2 delineate a transition in the acquisition of the blood potential from hemangioblast to hemogenic endothelium leading to the formation of primitive and definitive hematopoietic progenitors.
Title: The sequential expression of CD40 and Icam2 defines progressive steps in the formation of blood precursors from the mesoderm germ layer.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Spontaneous (1) 1 citation
Targeted (1) 1 citation

General gene information

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Markers

Icam2 (e-PCR), detects polymorphism
- UniSTS:143446

X65490 (e-PCR)
- UniSTS:163520

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in cleavage furrow	IEA Inferred from Electronic Annotation more info
located_in cleavage furrow	ISO Inferred from Sequence Orthology more info
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in uropod	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: intercellular adhesion molecule 2

Names: lymphocyte function-associated AG-1 counter-receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010494.2 → NP_034624.1 intercellular adhesion molecule 2 precursor

See identical proteins and their annotated locations for NP_034624.1

Status: VALIDATED

Source sequence(s)

AL604045, X65493

Consensus CDS

CCDS25555.1

UniProtKB/Swiss-Prot

P35330, Q9D8Q4

Related

ENSMUSP00000001055.9, ENSMUST00000001055.15

Conserved Domains (2) summary

pfam03921
Location:23 → 114

ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain

cl11960
Location:112 → 200

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

106268482..106278948 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011248762.4 → XP_011247064.1 intercellular adhesion molecule 2 isoform X1

See identical proteins and their annotated locations for XP_011247064.1

Conserved Domains (2) summary

pfam03921
Location:59 → 150

ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain

cl11960
Location:148 → 236

Ig; Immunoglobulin domain
XM_006532303.3 → XP_006532366.1 intercellular adhesion molecule 2 isoform X2

See identical proteins and their annotated locations for XP_006532366.1

UniProtKB/Swiss-Prot

P35330, Q9D8Q4

Conserved Domains (2) summary

pfam03921
Location:23 → 114

ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain

cl11960
Location:112 → 200

Ig; Immunoglobulin domain
XM_011248763.4 → XP_011247065.1 intercellular adhesion molecule 2 isoform X1

See identical proteins and their annotated locations for XP_011247065.1

Conserved Domains (2) summary

pfam03921
Location:59 → 150

ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain

cl11960
Location:148 → 236

Ig; Immunoglobulin domain
XM_030245595.2 → XP_030101455.1 intercellular adhesion molecule 2 isoform X2

UniProtKB/Swiss-Prot

P35330, Q9D8Q4

Conserved Domains (2) summary

pfam03921
Location:23 → 114

ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain

cl11960
Location:112 → 200

Ig; Immunoglobulin domain
XM_011248761.4 → XP_011247063.1 intercellular adhesion molecule 2 isoform X1

See identical proteins and their annotated locations for XP_011247063.1

Conserved Domains (2) summary

pfam03921
Location:59 → 150

ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain

cl11960
Location:148 → 236

Ig; Immunoglobulin domain