Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Grin1provided by MGI
Official Full Name: glutamate receptor, ionotropic, NMDA1 (zeta 1)provided by MGI
Primary source: MGI:MGI:95819
See related: Ensembl:ENSMUSG00000026959 AllianceGenome:MGI:95819
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NR1; GluN1; Nmdar; NMD-R1; NMDAR1; M100174; Rgsc174; GluRzeta1; GluRdelta1
Summary: Enables several functions, including calmodulin binding activity; cation binding activity; and monoatomic ion channel activity. Involved in calcium ion transmembrane transport; propylene metabolic process; and regulation of synaptic plasticity. Acts upstream of or within several processes, including chemical synaptic transmission; learning or memory; and regulation of neuron projection development. Located in several cellular components, including postsynaptic density; postsynaptic membrane; and synaptic vesicle membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; sensory organ; and skeleton. Used to study autism spectrum disorder and schizophrenia. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant intellectual developmental disorder 8; cerebral infarction; and developmental and epileptic encephalopathy 101. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in cortex adult (RPKM 73.7), frontal lobe adult (RPKM 72.0) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 17.14 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (25181189..25209199, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (25291177..25319187, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Binding of activated Galphao to GRIN1 induces activation of Cdc42, which leads to morphological changes in neuronal cells.
Title: Functional characterization of Galphao signaling through G protein-regulated inducer of neurite outgrowth 1.
Data show that GRIN1 expression was limited to the nervous system at all developmental stages tested. GRIN1 colocalized with Galphao at neuronal dendrites and axons, but it was not detected in glial cells.
Title: Dynamic expression patterns of G protein-regulated inducer of neurite outgrowth 1 (GRIN1) and its colocalization with Galphao implicate significant roles of Galphao-GRIN1 signaling in nervous system.
responses to social novelty and nonspatial change remained unaffected, indicating that the Grin1(D481N) mutation induces selective deficits in sociability and spatial discrimination, while leaving intact the ability to react to novelty.
Title: Mice with reduced NMDA receptor glycine affinity model some of the negative and cognitive symptoms of schizophrenia.
Src dependency of the regulation of LTP by alternative splicing of GRIN1 exon 5.
Title: Src dependency of the regulation of LTP by alternative splicing of GRIN1 exon 5.
Foxg1 regulates translation of neocortical neuronal genes, including the main NMDA receptor subunit gene, Grin1.
Title: Foxg1 regulates translation of neocortical neuronal genes, including the main NMDA receptor subunit gene, Grin1.
TFAP2A is involved in neuropathic pain by regulating Grin1 expression in glial cells of the dorsal root ganglion.
Title: TFAP2A is involved in neuropathic pain by regulating Grin1 expression in glial cells of the dorsal root ganglion.
NR1 Splicing Variant NR1a in Cerebellar Granule Neurons Constitutes a Better Motor Learning in the Mouse.
Title: NR1 Splicing Variant NR1a in Cerebellar Granule Neurons Constitutes a Better Motor Learning in the Mouse.
Notoginsenoside R1 targets PPAR-gamma to inhibit hepatic stellate cell activation and ameliorates liver fibrosis.
Title: Notoginsenoside R1 targets PPAR-γ to inhibit hepatic stellate cell activation and ameliorates liver fibrosis.
The Expression and Functionality of CB1R-NMDAR Complexes Are Decreased in A Parkinson's Disease Model.
Title: The Expression and Functionality of CB(1)R-NMDAR Complexes Are Decreased in A Parkinson's Disease Model.
N-methyl-D-aspartate receptor regulates the circadian clock in megakaryocytic cells and impacts cell proliferation through BMAL1.
Title: N-methyl-D-aspartate receptor regulates the circadian clock in megakaryocytic cells and impacts cell proliferation through BMAL1.

Submit: New GeneRIF Correction See all GeneRIFs (221)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (3)
Targeted (27) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Grin1 (e-PCR), detects polymorphism
- UniSTS:506952

NoName (e-PCR)
- UniSTS:234346

Grin1 (e-PCR), detects polymorphism
- UniSTS:143260

D2Bwg0161e (e-PCR), detects polymorphism
- UniSTS:142290

PMC57740P2 (e-PCR)
- UniSTS:273365

UniSTS:465388 (e-PCR)
- UniSTS:465388

Grin1 (e-PCR), detects polymorphism
- UniSTS:465388

Grin1 (e-PCR), detects polymorphism
- UniSTS:531447

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to NMDA glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables NMDA glutamate receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables NMDA glutamate receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables NMDA glutamate receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to NMDA glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables NMDA glutamate receptor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium channel activity	IGI Inferred from Genetic Interaction more info	PubMed
contributes_to calcium channel activity	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables glutamate binding	ISO Inferred from Sequence Orthology more info
enables glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables glutamate-gated calcium ion channel activity	ISO Inferred from Sequence Orthology more info
enables glutamate-gated calcium ion channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables glutamate-gated receptor activity	ISO Inferred from Sequence Orthology more info
enables glycine binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables glycine binding	ISO Inferred from Sequence Orthology more info
enables glycine binding	ISS Inferred from Sequence or Structural Similarity more info
enables ionotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables ligand-gated sodium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables monoatomic cation channel activity	IGI Inferred from Genetic Interaction more info	PubMed
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables voltage-gated monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within associative learning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within calcium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transmembrane import into cytosol	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cerebral cortex development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemical synaptic transmission	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within conditioned taste aversion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within excitatory postsynaptic potential	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ionotropic glutamate receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ionotropic glutamate receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ionotropic glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ionotropic glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ionotropic glutamate receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within learning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male mating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic cation transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within monoatomic cation transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in monoatomic cation transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuromuscular process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pons maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Schwann cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of calcium ion transport into cytosol	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine maintenance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of reactive oxygen species biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, glutamatergic	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within prepulse inhibition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in propylene metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein heterotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein heterotetramerization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein localization to postsynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell communication	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of monoatomic cation transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of monoatomic cation transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuronal synaptic plasticity	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of respiratory gaseous exchange	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic plasticity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to amphetamine	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to amphetamine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in response to glycine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to morphine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rhythmic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within social behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within startle response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within suckling behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within visual learning	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within visual learning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of NMDA selective glutamate receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NMDA selective glutamate receptor complex	IPI Inferred from Physical Interaction more info	PubMed
part_of NMDA selective glutamate receptor complex	ISO Inferred from Sequence Orthology more info
part_of NMDA selective glutamate receptor complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IMP Inferred from Mutant Phenotype more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite membrane	ISO Inferred from Sequence Orthology more info
located_in dendritic branch	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in excitatory synapse	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	NAS Non-traceable Author Statement more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
part_of neurotransmitter receptor complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in parallel fiber to Purkinje cell synapse	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info	PubMed
located_in synaptic cleft	ISO Inferred from Sequence Orthology more info
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	ISO Inferred from Sequence Orthology more info
located_in transport vesicle membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: glutamate receptor ionotropic, NMDA 1

Names: N-methyl-D-aspartate receptor subunit NR1; glutamate [NMDA] receptor subunit zeta-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177656.2 → NP_001171127.1 glutamate receptor ionotropic, NMDA 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an additional in-frame exon in the 5' coding region, and lacks an exon and contains an alternate 3' terminal exon, resulting in an alternate 3' coding region, compared to variant 1. The encoded isoform (2) has distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AI844150, AK158175, BC039157, CD355382

Consensus CDS

CCDS50529.1

UniProtKB/TrEMBL

A2AI16, Q3TZ31

Related

ENSMUSP00000109956.4, ENSMUST00000114317.10

Conserved Domains (5) summary

cd06379
Location:8 → 404

PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor

cd13719
Location:416 → 820

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:582 → 845

Lig_chan; Ligand-gated ion channel

pfam01094
Location:42 → 378

ANF_receptor; Receptor family ligand binding region

pfam10562
Location:856 → 884

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
NM_001177657.2 → NP_001171128.1 glutamate receptor ionotropic, NMDA 1 isoform 3 precursor

See identical proteins and their annotated locations for NP_001171128.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an exon and contains an alternate 3' terminal exon, resulting in an alternate 3' coding region, compared to variant 1. The encoded isoform (3) has distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AI844150, BC039157, CD355382

Consensus CDS

CCDS50528.1

UniProtKB/TrEMBL

Q3TZ31

Related

ENSMUSP00000109951.2, ENSMUST00000114312.2

Conserved Domains (5) summary

cd06379
Location:8 → 383

PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor

cd13719
Location:395 → 799

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:561 → 824

Lig_chan; Ligand-gated ion channel

pfam01094
Location:42 → 357

ANF_receptor; Receptor family ligand binding region

pfam10562
Location:835 → 863

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
NM_001372558.1 → NP_001359487.1 glutamate receptor ionotropic, NMDA 1 isoform 4 precursor

Status: VALIDATED

Source sequence(s)

AL732309

Consensus CDS

CCDS89447.1

UniProtKB/TrEMBL

A2AI21

Related

ENSMUSP00000109949.4, ENSMUST00000114310.10

Conserved Domains (4) summary

cd13719
Location:416 → 820

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam07885
Location:622 → 677

Ion_trans_2; Ion channel

pfam10562
Location:856 → 884

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

cd06379
Location:25 → 404

PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
NM_001372559.1 → NP_001359488.1 glutamate receptor ionotropic, NMDA 1 isoform 5 precursor

Status: VALIDATED

Source sequence(s)

AL732309

Consensus CDS

CCDS89446.1

UniProtKB/TrEMBL

A2AI14

Related

ENSMUSP00000109957.4, ENSMUST00000114318.10

Conserved Domains (4) summary

cd13719
Location:416 → 820

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam07885
Location:622 → 677

Ion_trans_2; Ion channel

pfam10562
Location:856 → 884

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

cd06379
Location:25 → 404

PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
NM_001372560.1 → NP_001359489.1 glutamate receptor ionotropic, NMDA 1 isoform 6 precursor

Status: VALIDATED

Source sequence(s)

AL732309

Consensus CDS

CCDS89445.1

UniProtKB/TrEMBL

A2AI20, Q3TZ31

Related

ENSMUSP00000109947.4, ENSMUST00000114308.10

Conserved Domains (4) summary

cd13719
Location:416 → 820

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam07885
Location:622 → 677

Ion_trans_2; Ion channel

pfam10562
Location:856 → 884

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

cd06379
Location:25 → 404

PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
NM_001372561.1 → NP_001359490.1 glutamate receptor ionotropic, NMDA 1 isoform 7 precursor

Status: VALIDATED

Source sequence(s)

AL732309

Consensus CDS

CCDS89444.1

UniProtKB/TrEMBL

A2AI17, Q3TZ31

Related

ENSMUSP00000109953.4, ENSMUST00000114314.10

Conserved Domains (4) summary

cd13719
Location:395 → 799

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam07885
Location:601 → 656

Ion_trans_2; Ion channel

pfam10562
Location:835 → 863

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

cd06379
Location:25 → 383

PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
NM_001372562.1 → NP_001359491.1 glutamate receptor ionotropic, NMDA 1 isoform 8 precursor

Status: VALIDATED

Source sequence(s)

AL732309

Consensus CDS

CCDS89443.1

UniProtKB/TrEMBL

A2AI19, Q3TZ31

Related

ENSMUSP00000109946.2, ENSMUST00000114307.8

Conserved Domains (4) summary

cd13719
Location:395 → 799

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam07885
Location:601 → 656

Ion_trans_2; Ion channel

pfam10562
Location:835 → 863

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

cd06379
Location:25 → 383

PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
NM_008169.3 → NP_032195.1 glutamate receptor ionotropic, NMDA 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_032195.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform (1).

Source sequence(s)

AI844150, AW494928, BC039157, CD355382, CD363997

Consensus CDS

CCDS15764.1

UniProtKB/Swiss-Prot

A2AI15, A2AI18, P35438, Q8CFS4

Related

ENSMUSP00000028335.7, ENSMUST00000028335.13

Conserved Domains (6) summary

cd06379
Location:8 → 383

PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor

cd13719
Location:395 → 799

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:561 → 824

Lig_chan; Ligand-gated ion channel

pfam01094
Location:42 → 357

ANF_receptor; Receptor family ligand binding region

pfam07885
Location:602 → 656

Ion_trans_2; Ion channel

pfam10562
Location:835 → 863

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit