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    Ldoc1 regulator of NFKB signaling [ Mus musculus (house mouse) ]

    Gene ID: 434784, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ldoc1provided by MGI
    Official Full Name
    regulator of NFKB signalingprovided by MGI
    Primary source
    MGI:MGI:2685212
    See related
    Ensembl:ENSMUSG00000057615 AllianceGenome:MGI:2685212
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mar7; Rtl7; Gm366; Mart7; Sirh7
    Summary
    Acts upstream of or within maternal placenta development; maternal process involved in parturition; and regulation of growth hormone activity. Predicted to be located in nucleolus and nucleoplasm. Is expressed in brain and ovary. Orthologous to human LDOC1 (LDOC1 regulator of NFKB signaling). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human all
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    Genomic context

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    See Ldoc1 in Genome Data Viewer
    Location:
    X A6; X 34.57 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (60753217..60754556)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (61709611..61710950)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein SA pseudogene Neighboring gene crumbs homolog 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47249 Neighboring gene STARR-seq mESC enhancer starr_47252 Neighboring gene eukaryotic translation initiation factor 4E pseudogene Neighboring gene nuclear receptor corepressor 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sirh7/Ldoc1 knockout mice exhibit placental P4 overproduction and delayed parturition. Naruse M, et al. Development, 2014 Dec. PMID 25468940, Free PMC Article
    2. Matrix metalloproteinase-8 regulates transforming growth factor-β1 levels in mouse tongue wounds and fibroblasts in vitro. Åström P, et al. Exp Cell Res, 2014 Oct 15. PMID 25036555
    3. Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. Brandt J, et al. Gene, 2005 Jan 17. PMID 15716091
    4. A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes. Brandt J, et al. Cytogenet Genome Res, 2005. PMID 16093683
    5. A Grhl2-dependent gene network controls trophoblast branching morphogenesis. Walentin K, et al. Development, 2015 Mar 15. PMID 25758223, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to lipopolysaccharide ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to muramyl dipeptide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to muramyl dipeptide ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within maternal placenta development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within maternal process involved in parturition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of growth hormone activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein LDOC1
    Names
    breast cancer, up-regulated 1
    leucine zipper, down-regulated in cancer 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001018087.2 → NP_001018097.1  protein LDOC1

      Status: VALIDATED

      Source sequence(s)
      AL672025, BC052689
      Consensus CDS
      CCDS30163.1
      UniProtKB/Swiss-Prot
      B1AV12, Q7TPY9
      Related
      ENSMUSP00000075366.5, ENSMUST00000075983.6
      Conserved Domains (1) summary
      pfam16297
      Location:27 → 131
      DUF4939; Domain of unknown function (DUF4939)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      60753217..60754556
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TPY9.1 GenPept UniProtKB/Swiss-Prot:Q7TPY9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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