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    Cpped1 calcineurin-like phosphoesterase domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 223978, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Cpped1provided by MGI
    Official Full Name
    calcineurin-like phosphoesterase domain containing 1provided by MGI
    Primary source
    MGI:MGI:2443300
    See related
    Ensembl:ENSMUSG00000065979 AllianceGenome:MGI:2443300
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C530044N13Rik
    Summary
    Predicted to enable metal ion binding activity and phosphoprotein phosphatase activity. Predicted to be involved in chromatin remodeling and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and plasma membrane. Orthologous to human CPPED1 (calcineurin like phosphoesterase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 6.8), large intestine adult (RPKM 6.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cpped1 in Genome Data Viewer
    Location:
    16 A1; 16 6.61 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (11621546..11727377, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (11803684..11909476, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene sorting nexin 29 Neighboring gene predicted gene, 32100 Neighboring gene STARR-seq mESC enhancer starr_40110 Neighboring gene RIKEN cDNA 4833415N18 gene Neighboring gene STARR-seq mESC enhancer starr_40111 Neighboring gene STARR-seq mESC enhancer starr_40112 Neighboring gene predicted gene 9961 Neighboring gene predicted gene, 32278 Neighboring gene shisa family member 9 Neighboring gene STARR-seq mESC enhancer starr_40114 Neighboring gene predicted gene, 19571

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC27760

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase CPPED1
    Names
    Vcalcineurin-like phosphoesterase domain containing 1
    calcineurin-like phosphoesterase domain-containing protein 1
    NP_001404625.1
    NP_001404626.1
    NP_001404651.1
    NP_001404652.1
    NP_001404653.1
    NP_666179.2
    XP_006522078.1
    XP_006522079.1
    XP_036015773.1
    XP_036015774.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417696.1 → NP_001404625.1  serine/threonine-protein phosphatase CPPED1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154508, AC154509

    2. NM_001417697.1 → NP_001404626.1  serine/threonine-protein phosphatase CPPED1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154508, AC154509
      Related
      ENSMUSP00000112587.2, ENSMUST00000121750.2

    3. NM_001417722.1 → NP_001404651.1  serine/threonine-protein phosphatase CPPED1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC154508, AC154509

    4. NM_001417723.1 → NP_001404652.1  serine/threonine-protein phosphatase CPPED1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC154508, AC154509

    5. NM_001417724.1 → NP_001404653.1  serine/threonine-protein phosphatase CPPED1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC154508, AC154509

    6. NM_146067.4 → NP_666179.2  serine/threonine-protein phosphatase CPPED1 isoform 1

      See identical proteins and their annotated locations for NP_666179.2

      Status: VALIDATED

      Source sequence(s)
      AC154508, AC154509
      Consensus CDS
      CCDS27964.1
      UniProtKB/Swiss-Prot
      Q3UYF7, Q8BFS6, Q8BJQ3, Q8BYB7, Q8K236, Q8R3G2
      Related
      ENSMUSP00000093992.5, ENSMUST00000096272.11
      Conserved Domains (2) summary
      COG1409
      Location:33 → 268
      CpdA; 3',5'-cyclic AMP phosphodiesterase CpdA [Signal transduction mechanisms]
      cd07395
      Location:29 → 294
      MPP_CSTP1; Homo sapiens CSTP1 and related proteins, metallophosphatase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      11621546..11727377 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159880.1 → XP_036015773.1  serine/threonine-protein phosphatase CPPED1 isoform X2

      Conserved Domains (1) summary
      cl13995
      Location:2 → 172
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain

    2. XM_006522016.4 → XP_006522079.1  serine/threonine-protein phosphatase CPPED1 isoform X3

      See identical proteins and their annotated locations for XP_006522079.1

      Conserved Domains (1) summary
      cl13995
      Location:53 → 120
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain

    3. XM_006522015.4 → XP_006522078.1  serine/threonine-protein phosphatase CPPED1 isoform X3

      See identical proteins and their annotated locations for XP_006522078.1

      Conserved Domains (1) summary
      cl13995
      Location:53 → 120
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain

    4. XM_036159881.1 → XP_036015774.1  serine/threonine-protein phosphatase CPPED1 isoform X3

      Related
      ENSMUSP00000089104.6, ENSMUST00000073371.7
      Conserved Domains (1) summary
      cl13995
      Location:53 → 120
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BFS6.1 GenPept UniProtKB/Swiss-Prot:Q8BFS6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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