Tuba8 tubulin, alpha 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tuba8provided by MGI
Official Full Name: tubulin, alpha 8provided by MGI
Primary source: MGI:MGI:1858225
See related: Ensembl:ENSMUSG00000030137 AllianceGenome:MGI:1858225
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: This gene encodes a member of the tubulin family of cytoskeletal proteins that form the integral component of microtubules. This gene is preferentially expressed in heart, skeletal muscle and testis. The encoded protein may play a role in liver tumorigenesis in mice. [provided by RefSeq, Sep 2015]
Expression: Biased expression in testis adult (RPKM 94.0), heart adult (RPKM 37.0) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F1; 6 57.15 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (121187666..121209304)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (121210734..121226098)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data (including data from studies conducted in knockout mice) suggest that Snta1 is involved in regulation of expression of Tuba8 in hepatocytes (but not in hepatic stellate cells); here, Snta1 protein levels are inversely related to Tuba8 protein expression in hepatocyte cell line. (Snta1 = syntrophin alpha-1; Tuba8 = tubulin alpha-8 chain)
Title: Alpha-syntrophin dependent expression of tubulin alpha 8 protein in hepatocytes.
Data provide evidence for a role of TUBA8 in hepatic fibrogenesis and malignancies making it a novel player in non-alcoholic steatohepatitis and hepatocellular carcinoma pathology.
Title: Tubulin alpha 8 is expressed in hepatic stellate cells and is induced in transformed hepatocytes.
TUBA8 can play a role in the regulation of cell growth, proliferation, and cell migration in a cell-specific manner in vitro.
Title: Role of a novel CAR-induced gene, TUBA8, in hepatocellular carcinoma cell lines.
Tuba8 is expressed at low levels in the developing mouse brain.
Title: Tuba8 is expressed at low levels in the developing mouse and human brain.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tuba8 (e-PCR), detects polymorphism
- UniSTS:532394

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of cytoskeleton	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within microtubule cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in acrosomal vesicle	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	TAS Traceable Author Statement more info	PubMed
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tubulin alpha-8 chain

Names: alpha tubulin 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017379.2 → NP_059075.1 tubulin alpha-8 chain

See identical proteins and their annotated locations for NP_059075.1

Status: REVIEWED

Source sequence(s)

AC153584, AJ245923, BC017631

Consensus CDS

CCDS39615.1

UniProtKB/Swiss-Prot

D4P911, Q9CV57, Q9JJZ2

UniProtKB/TrEMBL

A0A0A0MQA5

Related

ENSMUSP00000032233.8, ENSMUST00000032233.9

Conserved Domains (1) summary

PTZ00335
Location:1 → 439

PTZ00335; tubulin alpha chain; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

121187666..121209304

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036166283.1 → XP_036022176.1 tubulin alpha-8 chain isoform X1

UniProtKB/TrEMBL

Q99KA2

Conserved Domains (1) summary

PTZ00335
Location:1 → 373

PTZ00335; tubulin alpha chain; Provisional