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    TASP1 taspase 1 [ Homo sapiens (human) ]

    Gene ID: 55617, updated on 3-Dec-2024

    Summary

    Official Symbol
    TASP1provided by HGNC
    Official Full Name
    taspase 1provided by HGNC
    Primary source
    HGNC:HGNC:15859
    See related
    Ensembl:ENSG00000089123 MIM:608270; AllianceGenome:HGNC:15859
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SULEHS; C20orf13; dJ585I14.2
    Summary
    This gene encodes an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 2.9), testis (RPKM 2.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TASP1 in Genome Data Viewer
    Location:
    20p12.1
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (13104772..13638932, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (13148109..13682349, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (13370041..13619579, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1722 Neighboring gene Sharpr-MPRA regulatory region 3567 Neighboring gene long intergenic non-protein coding RNA 1723 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:12980521-12980692 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:13010129-13011328 Neighboring gene serine palmitoyltransferase long chain base subunit 3 Neighboring gene CENATAC pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17549 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17550 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12677 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12678 Neighboring gene Sharpr-MPRA regulatory region 1935 Neighboring gene Sharpr-MPRA regulatory region 7489 Neighboring gene ISM1 antisense RNA 1 Neighboring gene isthmin 1 Neighboring gene uncharacterized LOC124904872 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr20:13337123-13337628 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:13338225-13339146 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:13342069-13342904 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:13342905-13343739 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene 2 Neighboring gene mitochondrial ribosomal protein S36 pseudogene 6 Neighboring gene NANOG hESC enhancer GRCh37_chr20:13516637-13517168 Neighboring gene Sharpr-MPRA regulatory region 15076 Neighboring gene Sharpr-MPRA regulatory region 9064 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:13618936-13619436 Neighboring gene Sharpr-MPRA regulatory region 128 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17552 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr20:13765895-13766584 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12680 Neighboring gene ESF1 nucleolar pre-rRNA processing protein homolog Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ20212, MGC39159

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables threonine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables threonine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables threonine-type endopeptidase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in epigenetic regulation of gene expression TAS
    Traceable Author Statement
    more info
     
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    threonine aspartase 1
    NP_001310531.1
    NP_001310532.1
    NP_001310533.1
    NP_060184.2
    XP_016883418.1
    XP_016883420.1
    XP_047296223.1
    XP_047296224.1
    XP_047296225.1
    XP_047296226.1
    XP_047296227.1
    XP_047296228.1
    XP_047296229.1
    XP_047296230.1
    XP_047296231.1
    XP_047296232.1
    XP_047296233.1
    XP_054179622.1
    XP_054179623.1
    XP_054179624.1
    XP_054179625.1
    XP_054179626.1
    XP_054179627.1
    XP_054179628.1
    XP_054179629.1
    XP_054179630.1
    XP_054179631.1
    XP_054179632.1
    XP_054179633.1
    XP_054179634.1
    XP_054179635.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001323602.2NP_001310531.1  threonine aspartase 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL121754, AL121782, AL601028, CA418131
      Conserved Domains (1) summary
      cd04514
      Location:42285
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
    2. NM_001323603.2NP_001310532.1  threonine aspartase 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL121754, AL121782, CA418131
      Conserved Domains (1) summary
      cd04514
      Location:2314
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
    3. NM_001323604.2NP_001310533.1  threonine aspartase 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL121754, AL121782, CA418131
      Conserved Domains (1) summary
      cd04514
      Location:2314
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
    4. NM_017714.3NP_060184.2  threonine aspartase 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_060184.2

      Status: REVIEWED

      Source sequence(s)
      AL601028, BC025266, CA418131
      Consensus CDS
      CCDS13116.1
      UniProtKB/Swiss-Prot
      B7Z690, B7Z963, Q5TDU9, Q9BQN0, Q9H6P5, Q9NQ08, Q9NTS6, Q9NXJ2
      Related
      ENSP00000338624.4, ENST00000337743.9
      Conserved Domains (1) summary
      cd04514
      Location:42416
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins

    RNA

    1. NR_136628.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL121754, AL121782, CA418131
    2. NR_136629.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL121754, AL121782, AL601028, CA418131
    3. NR_136630.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL121754, AL121782, AL601028, CA418131
    4. NR_136631.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL121754, AL121782, AL601028, CA418131

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      13104772..13638932 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047440269.1XP_047296225.1  threonine aspartase 1 isoform X2

    2. XM_047440275.1XP_047296231.1  threonine aspartase 1 isoform X7

    3. XM_047440268.1XP_047296224.1  threonine aspartase 1 isoform X1

      UniProtKB/Swiss-Prot
      B7Z690, B7Z963, Q5TDU9, Q9BQN0, Q9H6P5, Q9NQ08, Q9NTS6, Q9NXJ2
    4. XM_047440267.1XP_047296223.1  threonine aspartase 1 isoform X1

      UniProtKB/Swiss-Prot
      B7Z690, B7Z963, Q5TDU9, Q9BQN0, Q9H6P5, Q9NQ08, Q9NTS6, Q9NXJ2
    5. XM_047440273.1XP_047296229.1  threonine aspartase 1 isoform X6

    6. XM_047440274.1XP_047296230.1  threonine aspartase 1 isoform X6

    7. XM_047440276.1XP_047296232.1  threonine aspartase 1 isoform X9

    8. XM_047440271.1XP_047296227.1  threonine aspartase 1 isoform X4

      Related
      ENSP00000400580.1, ENST00000455532.5
    9. XM_047440270.1XP_047296226.1  threonine aspartase 1 isoform X3

      UniProtKB/TrEMBL
      E9PAQ0, Q5JWM4
    10. XM_047440272.1XP_047296228.1  threonine aspartase 1 isoform X5

    11. XM_017027929.3XP_016883418.1  threonine aspartase 1 isoform X8

    12. XM_017027931.3XP_016883420.1  threonine aspartase 1 isoform X10

    13. XM_047440277.1XP_047296233.1  threonine aspartase 1 isoform X10

    RNA

    1. XR_001754319.3 RNA Sequence

    2. XR_007067463.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      13148109..13682349 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323648.1XP_054179623.1  threonine aspartase 1 isoform X1

      UniProtKB/Swiss-Prot
      B7Z690, B7Z963, Q5TDU9, Q9BQN0, Q9H6P5, Q9NQ08, Q9NTS6, Q9NXJ2
    2. XM_054323647.1XP_054179622.1  threonine aspartase 1 isoform X1

      UniProtKB/Swiss-Prot
      B7Z690, B7Z963, Q5TDU9, Q9BQN0, Q9H6P5, Q9NQ08, Q9NTS6, Q9NXJ2
    3. XM_054323656.1XP_054179631.1  threonine aspartase 1 isoform X7

    4. XM_054323654.1XP_054179629.1  threonine aspartase 1 isoform X6

    5. XM_054323655.1XP_054179630.1  threonine aspartase 1 isoform X6

    6. XM_054323658.1XP_054179633.1  threonine aspartase 1 isoform X9

    7. XM_054323652.1XP_054179627.1  threonine aspartase 1 isoform X4

    8. XM_054323651.1XP_054179626.1  threonine aspartase 1 isoform X3

      UniProtKB/TrEMBL
      E9PAQ0, Q5JWM4
    9. XM_054323653.1XP_054179628.1  threonine aspartase 1 isoform X5

    10. XM_054323649.1XP_054179624.1  threonine aspartase 1 isoform X11

      UniProtKB/TrEMBL
      E9PAQ0, Q5JWM4
    11. XM_054323650.1XP_054179625.1  threonine aspartase 1 isoform X12

    12. XM_054323657.1XP_054179632.1  threonine aspartase 1 isoform X8

    13. XM_054323659.1XP_054179634.1  threonine aspartase 1 isoform X10

    14. XM_054323660.1XP_054179635.1  threonine aspartase 1 isoform X10

    RNA

    1. XR_008485269.1 RNA Sequence

    2. XR_008485268.1 RNA Sequence