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    Itsn2 intersectin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313934, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Itsn2provided by RGD
    Official Full Name
    intersectin 2provided by RGD
    Primary source
    RGD:1590890
    See related
    EnsemblRapid:ENSRNOG00000046741 AllianceGenome:RGD:1590890
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable molecular adaptor activity. Predicted to be involved in clathrin-dependent synaptic vesicle endocytosis and positive regulation of dendrite extension. Predicted to be located in centrosome. Predicted to be active in cytoplasm; intracellular vesicle; and presynaptic membrane. Orthologous to human ITSN2 (intersectin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 307.8), Thymus (RPKM 234.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Itsn2 in Genome Data Viewer
    Location:
    6q14
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (33336086..33446818)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (27616645..27727373)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (30098378..30208694, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479112 Neighboring gene uncharacterized LOC134479114 Neighboring gene ribosomal protein L29, pseudogene 6 Neighboring gene family with sequence similarity 228, member A Neighboring gene uncharacterized LOC134479113 Neighboring gene family with sequence similarity 228, member B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Cdc42 GEF Intersectin 2 controls mitotic spindle orientation to form the lumen during epithelial morphogenesis. Rodriguez-Fraticelli AE, et al. J Cell Biol, 2010 May 17. PMID 20479469, Free PMC Article
    2. FCHo proteins are nucleators of clathrin-mediated endocytosis. Henne WM, et al. Science, 2010 Jun 4. PMID 20448150, Free PMC Article
    3. SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation. Yoo JC, et al. J Dermatol Sci, 2013 Dec. PMID 23999003
    4. Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly. Schmid EM, et al. PLoS Biol, 2006 Sep. PMID 16903783, Free PMC Article
    5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in clathrin-dependent synaptic vesicle endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    intersectin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427104.1 → NP_001414033.1  intersectin-2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6ASA9, A6HAI3
      Related
      ENSRNOP00000094789.1, ENSRNOT00000100901.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      33336086..33446818
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039113103.2 → XP_038969031.1  intersectin-2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A8K6, M0R7A6
      Related
      ENSRNOP00000065329.3, ENSRNOT00000074150.5
      Conserved Domains (11) summary
      PTZ00121
      Location:347 → 797
      PTZ00121; MAEBL; Provisional
      cd08375
      Location:1574 → 1708
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15 → 107
      EH; Eps15 homology domain
      cd11988
      Location:780 → 836
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:921 → 972
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:1004 → 1055
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:1076 → 1134
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:1149 → 1202
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:1233 → 1413
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam16652
      Location:1431 → 1574
      PH_13; Pleckstrin homology domain
      cd21577
      Location:106 → 185
      KLF3_N; N-terminal domain of Kruppel-like factor 3

    2. XM_039113108.2 → XP_038969036.1  intersectin-2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AMD2, A6HAI3
      Related
      ENSRNOP00000096723.1, ENSRNOT00000119587.2
      Conserved Domains (11) summary
      cd08375
      Location:1514 → 1648
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15 → 107
      EH; Eps15 homology domain
      cd11988
      Location:720 → 776
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:861 → 912
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:944 → 995
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:1016 → 1074
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:1089 → 1142
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:1173 → 1353
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      COG1196
      Location:350 → 726
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam16652
      Location:1371 → 1514
      PH_13; Pleckstrin homology domain
      cd21577
      Location:106 → 185
      KLF3_N; N-terminal domain of Kruppel-like factor 3

    3. XM_063261879.1 → XP_063117949.1  intersectin-2 isoform X9

      UniProtKB/TrEMBL
      A6HAI6

    4. XM_039113102.2 → XP_038969030.1  intersectin-2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A8K6, M0R7A6
      Related
      ENSRNOP00000089614.1, ENSRNOT00000099866.2
      Conserved Domains (11) summary
      PTZ00121
      Location:347 → 797
      PTZ00121; MAEBL; Provisional
      cd08375
      Location:1574 → 1708
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15 → 107
      EH; Eps15 homology domain
      cd11988
      Location:780 → 836
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:921 → 972
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:1004 → 1055
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:1076 → 1134
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:1149 → 1202
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:1233 → 1413
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam16652
      Location:1431 → 1574
      PH_13; Pleckstrin homology domain
      cd21577
      Location:106 → 185
      KLF3_N; N-terminal domain of Kruppel-like factor 3

    5. XM_039113105.2 → XP_038969033.1  intersectin-2 isoform X2

      UniProtKB/TrEMBL
      M0R7A6
      Conserved Domains (11) summary
      cd08375
      Location:1547 → 1681
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15 → 107
      EH; Eps15 homology domain
      cd11988
      Location:753 → 809
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:894 → 945
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:977 → 1028
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:1049 → 1107
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:1122 → 1175
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:1206 → 1386
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      COG1196
      Location:376 → 753
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam16652
      Location:1404 → 1547
      PH_13; Pleckstrin homology domain
      cd21577
      Location:106 → 185
      KLF3_N; N-terminal domain of Kruppel-like factor 3

    6. XM_039113106.2 → XP_038969034.1  intersectin-2 isoform X3

      UniProtKB/TrEMBL
      M0R7A6
      Conserved Domains (10) summary
      PTZ00121
      Location:318 → 768
      PTZ00121; MAEBL; Provisional
      cd08375
      Location:1545 → 1679
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15 → 107
      EH; Eps15 homology domain
      cd11988
      Location:751 → 807
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:892 → 943
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:975 → 1026
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:1047 → 1105
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:1120 → 1173
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:1204 → 1384
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam16652
      Location:1402 → 1545
      PH_13; Pleckstrin homology domain

    7. XM_063261877.1 → XP_063117947.1  intersectin-2 isoform X5

      UniProtKB/TrEMBL
      A6HAI3

    8. XM_039113109.2 → XP_038969037.1  intersectin-2 isoform X6

      UniProtKB/TrEMBL
      M0R7A6
      Conserved Domains (10) summary
      PTZ00121
      Location:347 → 797
      PTZ00121; MAEBL; Provisional
      smart00027
      Location:15 → 107
      EH; Eps15 homology domain
      cd11988
      Location:780 → 836
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:921 → 972
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:1004 → 1055
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:1076 → 1134
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:1149 → 1202
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:1233 → 1413
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam16652
      Location:1431 → 1574
      PH_13; Pleckstrin homology domain
      cd21577
      Location:106 → 185
      KLF3_N; N-terminal domain of Kruppel-like factor 3

    9. XM_039113110.2 → XP_038969038.1  intersectin-2 isoform X7

      UniProtKB/TrEMBL
      A6HAI6
      Conserved Domains (8) summary
      PTZ00121
      Location:347 → 797
      PTZ00121; MAEBL; Provisional
      smart00027
      Location:15 → 107
      EH; Eps15 homology domain
      cd11988
      Location:780 → 836
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:921 → 972
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:1004 → 1055
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:1076 → 1134
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:1149 → 1202
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      cd21577
      Location:106 → 185
      KLF3_N; N-terminal domain of Kruppel-like factor 3

    10. XM_063261878.1 → XP_063117948.1  intersectin-2 isoform X8

      UniProtKB/TrEMBL
      A6HAI6

    11. XM_039113104.2 → XP_038969032.1  intersectin-2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A8K6, M0R7A6
      Conserved Domains (11) summary
      PTZ00121
      Location:347 → 797
      PTZ00121; MAEBL; Provisional
      cd08375
      Location:1574 → 1708
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15 → 107
      EH; Eps15 homology domain
      cd11988
      Location:780 → 836
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:921 → 972
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:1004 → 1055
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:1076 → 1134
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:1149 → 1202
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:1233 → 1413
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam16652
      Location:1431 → 1574
      PH_13; Pleckstrin homology domain
      cd21577
      Location:106 → 185
      KLF3_N; N-terminal domain of Kruppel-like factor 3
    Nucleotide Protein Strain
    Heading Accession and Version

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