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    Creg2 cellular repressor of E1A-stimulated genes 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316353, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Creg2provided by RGD
    Official Full Name
    cellular repressor of E1A-stimulated genes 2provided by RGD
    Primary source
    RGD:1564056
    See related
    EnsemblRapid:ENSRNOG00000013991 AllianceGenome:RGD:1564056
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Creg2-ps1; RGD1564056
    Summary
    Predicted to be located in Golgi apparatus and endoplasmic reticulum. Predicted to be active in extracellular space. Orthologous to human CREG2 (cellular repressor of E1A stimulated genes 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 38.0) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Creg2 in Genome Data Viewer
    Location:
    9q22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (49367693..49441133, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (41872000..41945413, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (46328088..46402237, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 149, pseudogene 2 Neighboring gene small nucleolar RNA, C/D box 89 Neighboring gene ring finger protein 149 Neighboring gene uncharacterized LOC134480363 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene regulatory factor X8 Neighboring gene uncharacterized LOC108351918 Neighboring gene uncharacterized LOC120094674

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of novel members of the CREG family, putative secreted glycoproteins expressed specifically in brain. Kunita R, et al. Genomics, 2002 Nov. PMID 12408961
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein CREG2
    Names
    cellular repressor of E1A-stimulated genes 2, pseudogene 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      49367693..49441133 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008767069.3 → XP_008765291.1  protein CREG2 isoform X2

      UniProtKB/TrEMBL
      A6INM1
      Conserved Domains (1) summary
      cl00381
      Location:116 → 203
      PNPOx/FlaRed_like; Pyridoxine 5'-phosphate (PNP) oxidase-like and flavin reductase-like proteins

    2. XM_039084545.2 → XP_038940473.1  protein CREG2 isoform X1

      UniProtKB/TrEMBL
      A6INM1, D4A3H3
      Related
      ENSRNOP00000047210.6, ENSRNOT00000046557.7
      Conserved Domains (1) summary
      pfam13883
      Location:116 → 282
      Pyrid_oxidase_2; Pyridoxamine 5'-phosphate oxidase
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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