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    Cdkl5 cyclin-dependent kinase-like 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100362725, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cdkl5provided by RGD
    Official Full Name
    cyclin-dependent kinase-like 5provided by RGD
    Primary source
    RGD:2324133
    See related
    EnsemblRapid:ENSRNOG00000003742 AllianceGenome:RGD:2324133
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables small GTPase binding activity. Involved in several processes, including positive regulation of GTPase activity; positive regulation of dendritic spine development; and positive regulation of neurogenesis. Located in dendrite; perinuclear region of cytoplasm; and ruffle membrane. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Human ortholog(s) of this gene implicated in Rett syndrome; developmental and epileptic encephalopathy 2; intellectual disability; and visual epilepsy. Orthologous to human CDKL5 (cyclin dependent kinase like 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 192.7), Lung (RPKM 78.5) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cdkl5 in Genome Data Viewer
    Location:
    Xq14
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (37566320..37796766)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (33757605..33988075)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (35536396..35773204)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene BEN domain containing 2 Neighboring gene Scm polycomb group protein like 2 Neighboring gene gap junction protein, alpha 6 Neighboring gene transfer RNA valine (anticodon UAC) Neighboring gene retinoschisin 1 Neighboring gene protein phosphatase with EF-hand domain 1 Neighboring gene metallothionein 1F

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ciliary tip ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in dendrite cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density, intracellular component IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ruffle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cyclin-dependent kinase-like 5
    NP_001408462.1
    XP_017457779.1
    XP_038956382.1
    XP_038956383.1
    XP_063135763.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001421533.1NP_001408462.1  cyclin-dependent kinase-like 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      Related
      ENSRNOP00000098998.1, ENSRNOT00000174042.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      37566320..37796766
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039100455.1XP_038956383.1  cyclin-dependent kinase-like 5 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZVL4
      Conserved Domains (1) summary
      cd07848
      Location:11297
      STKc_CDKL5; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase Like 5
    2. XM_017602290.2XP_017457779.1  cyclin-dependent kinase-like 5 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVL4
      Related
      ENSRNOP00000107456.1, ENSRNOT00000150186.1
      Conserved Domains (1) summary
      cd07848
      Location:11297
      STKc_CDKL5; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase Like 5
    3. XM_039100454.2XP_038956382.1  cyclin-dependent kinase-like 5 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVL4
      Conserved Domains (1) summary
      cd07848
      Location:11297
      STKc_CDKL5; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase Like 5
    4. XM_063279693.1XP_063135763.1  cyclin-dependent kinase-like 5 isoform X3

      UniProtKB/TrEMBL
      D3ZG85, E1U7Q0
      Related
      ENSRNOP00000005061.6, ENSRNOT00000005061.8