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    Tmem135 transmembrane protein 135 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293098, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem135provided by RGD
    Official Full Name
    transmembrane protein 135provided by RGD
    Primary source
    RGD:1309948
    See related
    EnsemblRapid:ENSRNOG00000016815 AllianceGenome:RGD:1309948
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PMP52; RGD1309948
    Summary
    Involved in peroxisome organization. Located in peroxisome. Orthologous to human TMEM135 (transmembrane protein 135). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 245.9), Adrenal (RPKM 147.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem135 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (152418929..152692405, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (143006343..143279824, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (152886496..153096225, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene phosphoglycerate kinase 1, pseudogene 7 Neighboring gene ribosomal protein S19, pseudogene 10 Neighboring gene frizzled class receptor 4 Neighboring gene protein tyrosine phosphatase 4A1, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies. Lee WH, et al. Elife, 2016 Nov 15. PMID 27863209, Free PMC Article
    2. Proteomics characterization of mouse kidney peroxisomes by tandem mass spectrometry and protein correlation profiling. Wiese S, et al. Mol Cell Proteomics, 2007 Dec. PMID 17768142
    3. Rat liver peroxisomes after fibrate treatment. A survey using quantitative mass spectrometry. Islinger M, et al. J Biol Chem, 2007 Aug 10. PMID 17522052
    4. Stressed-induced TMEM135 protein is part of a conserved genetic network involved in fat storage and longevity regulation in Caenorhabditis elegans. Exil VJ, et al. PLoS One, 2010 Dec 3. PMID 21151927, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peroxisome organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitochondrial fission ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of oxidative phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to cold ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to food ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within retinal pigment epithelium development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 135
    Names
    peroxisomal membrane protein 52

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013896.1 → NP_001013918.1  transmembrane protein 135

      See identical proteins and their annotated locations for NP_001013918.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085115
      UniProtKB/Swiss-Prot
      Q5U4F4
      UniProtKB/TrEMBL
      A0A8I6G425, A6I5Z6
      Related
      ENSRNOP00000022578.4, ENSRNOT00000022578.7
      Conserved Domains (2) summary
      pfam02466
      Location:249 → 338
      Tim17; Tim17/Tim22/Tim23/Pmp24 family
      pfam15982
      Location:9 → 142
      TMEM135_C_rich; N-terminal cysteine-rich region of Transmembrane protein 135

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      152418929..152692405 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105814.2 → XP_038961742.1  transmembrane protein 135 isoform X3

      Conserved Domains (1) summary
      pfam02466
      Location:171 → 223
      Tim17; Tim17/Tim22/Tim23/Pmp24 family

    2. XM_039105818.2 → XP_038961746.1  transmembrane protein 135 isoform X4

      Conserved Domains (1) summary
      pfam02466
      Location:160 → 212
      Tim17; Tim17/Tim22/Tim23/Pmp24 family

    3. XM_039105799.2 → XP_038961727.1  transmembrane protein 135 isoform X1

      Conserved Domains (2) summary
      pfam15982
      Location:2 → 23
      TMEM135_C_rich; N-terminal cysteine-rich region of Transmembrane protein 135
      pfam02466
      Location:180 → 232
      Tim17; Tim17/Tim22/Tim23/Pmp24 family

    4. XM_039105807.2 → XP_038961735.1  transmembrane protein 135 isoform X2

      Conserved Domains (2) summary
      pfam15982
      Location:2 → 22
      TMEM135_C_rich; N-terminal cysteine-rich region of Transmembrane protein 135
      pfam02466
      Location:179 → 231
      Tim17; Tim17/Tim22/Tim23/Pmp24 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U4F4.1 GenPept UniProtKB/Swiss-Prot:Q5U4F4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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