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    Pcsk5 proprotein convertase subtilisin/kexin type 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116548, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pcsk5provided by RGD
    Official Full Name
    proprotein convertase subtilisin/kexin type 5provided by RGD
    Primary source
    RGD:620326
    See related
    EnsemblRapid:ENSRNOG00000012036 AllianceGenome:RGD:620326
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PC6; Pc5
    Summary
    Predicted to enable peptide binding activity and serine-type endopeptidase activity. Involved in several processes, including cellular response to platelet-derived growth factor stimulus; positive regulation of integrin-mediated signaling pathway; and positive regulation of smooth muscle cell-matrix adhesion. Located in Golgi apparatus subcompartment; perikaryon; and proximal dendrite. Biomarker of sciatic neuropathy. Orthologous to human PCSK5 (proprotein convertase subtilisin/kexin type 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 290.0), Lung (RPKM 88.4) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pcsk5 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (224263823..224694350, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (214837847..215267626, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (236031988..236313858)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene acyl-protein thioesterase 1-like Neighboring gene riboflavin kinase Neighboring gene small nucleolar RNA U13 Neighboring gene RNA, U6 small nuclear 1267 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in anterior/posterior pattern specification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in anterior/posterior pattern specification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac septum development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cardiac septum development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to platelet-derived growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in coronary vasculature development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within coronary vasculature development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytokine precursor processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytokine precursor processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in determination of left/right symmetry IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within determination of left/right symmetry ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in embryo implantation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryo implantation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in embryonic digestive tract development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic digestive tract development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in embryonic skeletal system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic skeletal system development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heart development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in kidney development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in limb morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in limb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptide hormone processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peptide hormone processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptide hormone processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of integrin activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of smooth muscle cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of vascular associated smooth muscle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in renin secretion into blood stream ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in respiratory tube development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in respiratory tube development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to gonadotropin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to luteinizing hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in signal peptide processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vascular associated smooth muscle cell proliferation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in viral life cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in viral life cycle ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi medial cisterna IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in proximal dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    proprotein convertase subtilisin/kexin type 5
    Names
    proprotein convertase 6
    subtilisin/kexin-like protease PC5
    NP_446275.1
    XP_038965620.1
    XP_038965657.1
    XP_038965700.1
    XP_038965735.1
    XP_063120334.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053823.1NP_446275.1  proprotein convertase subtilisin/kexin type 5 preproprotein

      See identical proteins and their annotated locations for NP_446275.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6I0J8
      Related
      ENSRNOP00000016164.4, ENSRNOT00000016164.9
      Conserved Domains (8) summary
      cd04059
      Location:128422
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:781825
      FU; Furin-like repeats
      cd00064
      Location:690739
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00082
      Location:164447
      Peptidase_S8; Subtilase family
      pfam01483
      Location:507597
      P_proprotein; Proprotein convertase P-domain
      pfam08686
      Location:888912
      PLAC; PLAC (protease and lacunin) domain
      pfam14843
      Location:637751
      GF_recep_IV; Growth factor receptor domain IV
      pfam16470
      Location:40116
      S8_pro-domain; Peptidase S8 pro-domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      224263823..224694350 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109729.2XP_038965657.1  proprotein convertase subtilisin/kexin type 5 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AKB3
      Conserved Domains (7) summary
      pfam03302
      Location:10421297
      VSP; Giardia variant-specific surface protein
      cd04059
      Location:128422
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:781825
      FU; Furin-like repeats
      cd00064
      Location:15181566
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam01483
      Location:507597
      P_proprotein; Proprotein convertase P-domain
      pfam14843
      Location:637751
      GF_recep_IV; Growth factor receptor domain IV
      pfam16470
      Location:40116
      S8_pro-domain; Peptidase S8 pro-domain
    2. XM_039109692.2XP_038965620.1  proprotein convertase subtilisin/kexin type 5 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AKB3
      Related
      ENSRNOP00000089163.2, ENSRNOT00000100985.2
      Conserved Domains (6) summary
      pfam03302
      Location:12931618
      VSP; Giardia variant-specific surface protein
      cd04059
      Location:128422
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:16421684
      FU; Furin-like repeats
      pfam01483
      Location:507597
      P_proprotein; Proprotein convertase P-domain
      pfam14843
      Location:637751
      GF_recep_IV; Growth factor receptor domain IV
      pfam16470
      Location:40116
      S8_pro-domain; Peptidase S8 pro-domain
    3. XM_039109772.2XP_038965700.1  proprotein convertase subtilisin/kexin type 5 isoform X3

      Conserved Domains (5) summary
      pfam03302
      Location:8451170
      VSP; Giardia variant-specific surface protein
      smart00261
      Location:10431087
      FU; Furin-like repeats
      cd00064
      Location:10971145
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam01483
      Location:59149
      P_proprotein; Proprotein convertase P-domain
      pfam14843
      Location:189303
      GF_recep_IV; Growth factor receptor domain IV
    4. XM_039109807.2XP_038965735.1  proprotein convertase subtilisin/kexin type 5 isoform X4

      UniProtKB/TrEMBL
      A6I0J7
      Conserved Domains (4) summary
      pfam03302
      Location:454779
      VSP; Giardia variant-specific surface protein
      smart00261
      Location:652696
      FU; Furin-like repeats
      cd00064
      Location:706754
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam14843
      Location:50156
      GF_recep_IV; Growth factor receptor domain IV
    5. XM_063264264.1XP_063120334.1  proprotein convertase subtilisin/kexin type 5 isoform X5