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    Sele selectin E [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25544, updated on 9-Dec-2024

    Summary

    Official Symbol
    Seleprovided by RGD
    Official Full Name
    selectin Eprovided by RGD
    Primary source
    RGD:3654
    See related
    EnsemblRapid:ENSRNOG00000002723 AllianceGenome:RGD:3654
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including oligosaccharide binding activity; phospholipase binding activity; and sialic acid binding activity. Involved in leukocyte migration and response to cytokine. Predicted to be located in several cellular components, including caveola; clathrin-coated pit; and perinuclear region of cytoplasm. Predicted to be active in external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; brain ischemia; cerebrovascular disease; and coronary artery disease. Orthologous to human SELE (selectin E). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 11.4), Lung (RPKM 6.1) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Sele in Genome Data Viewer
    Location:
    13q23
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (78935997..78945905)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (76402841..76412741)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (82355234..82365323)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555981 Neighboring gene peptidylprolyl isomerase D, pseudogene 19 Neighboring gene adenylate kinase 2, pseudogene 2 Neighboring gene COP9 signalosome subunit 8, pseudogene 1 Neighboring gene selectin L

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oligosaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables oligosaccharide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sialic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sialic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in actin filament-based process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leukocyte migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in leukocyte migration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of leukocyte migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leukocyte tethering or rolling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in leukocyte tethering or rolling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of leukocyte migration IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of leukocyte migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of leukocyte tethering or rolling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of leukocyte tethering or rolling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of leukocyte tethering or rolling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to cytokine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to cytokine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
     
    located_in clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cortical cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E-selectin
    Names
    CD62 antigen-like family member E
    ELAM-1
    LECAM2
    endothelial leukocyte adhesion molecule 1
    leukocyte-endothelial cell adhesion molecule 2
    selectin, endothelial cell

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138879.1NP_620234.1  E-selectin precursor

      See identical proteins and their annotated locations for NP_620234.1

      Status: PROVISIONAL

      Source sequence(s)
      L25527
      UniProtKB/Swiss-Prot
      P98105
      UniProtKB/TrEMBL
      A0A8L2R0D5
      Conserved Domains (3) summary
      cd00033
      Location:243301
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd03592
      Location:22140
      CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
      cd00054
      Location:148174
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      78935997..78945905
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008769608.4XP_008767830.1  E-selectin isoform X2

      See identical proteins and their annotated locations for XP_008767830.1

      UniProtKB/TrEMBL
      A0A0H2UHU5, A0A8I6AP16, A6IDD1
      Related
      ENSRNOP00000107229.1, ENSRNOT00000154598.1
      Conserved Domains (4) summary
      cd00033
      Location:250308
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd03592
      Location:29147
      CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
      PHA02927
      Location:310555
      PHA02927; secreted complement-binding protein; Provisional
      cd00054
      Location:155181
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    2. XM_017598678.3XP_017454167.1  E-selectin isoform X1

      UniProtKB/TrEMBL
      A0A8L2R0D5, A6IDD2
      Related
      ENSRNOP00000068171.3, ENSRNOT00000076757.3
      Conserved Domains (3) summary
      cd00033
      Location:250308
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd03592
      Location:29147
      CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
      cd00054
      Location:155181
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...