U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Uox urate oxidase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114768, updated on 3-Dec-2024

    Summary

    Official Symbol
    Uoxprovided by RGD
    Official Full Name
    urate oxidaseprovided by RGD
    Primary source
    RGD:621369
    See related
    EnsemblRapid:ENSRNOG00000016339 AllianceGenome:RGD:621369
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Uri; Uri2; UOX-2
    Summary
    Enables urate oxidase activity. Involved in urate catabolic process. Located in peroxisome. Used to study hyperuricemia. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 3195.8) See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Uox in Genome Data Viewer
    Location:
    2q44
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (238147130..238183320)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (235486867..235523053)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (252452282..252488497)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene G protein subunit gamma 5 Neighboring gene ribosome production factor 1 Neighboring gene small ribosomal subunit protein eS12-like Neighboring gene deoxyribonuclease 2 beta Neighboring gene uncharacterized LOC120100965 Neighboring gene sterile alpha motif domain containing 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables urate oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables urate oxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables urate oxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables urate oxidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in AMP catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in GMP catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in IMP catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adenosine catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in allantoin metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in amide catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dAMP catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dGMP catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in deoxyadenosine catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in deoxyguanosine catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in deoxyinosine catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in guanine catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hypoxanthine catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inosine catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in purine nucleobase catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in purine nucleobase catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in purine nucleobase metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in urate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in urate catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in urate catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in xanthine catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in peroxisomal matrix TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    uricase
    Names
    urate oxidase 2
    XP_006233512.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433782.1NP_001420711.1  uricase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8L2QB48
    2. NM_053768.3NP_446220.2  uricase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      P09118
      UniProtKB/TrEMBL
      A0A8L2QB48, A6HWE4
      Related
      ENSRNOP00000100526.1, ENSRNOT00000164743.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      238147130..238183320
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233450.4XP_006233512.1  uricase isoform X1

      Related
      ENSRNOP00000105950.1, ENSRNOT00000127252.1
      Conserved Domains (2) summary
      cd00445
      Location:13290
      Uricase; Urate oxidase (UO, uricase) is a peroxisomal enzyme that catalyzes the oxidation of uric acid to allantoin in most fish, amphibian, and mammalian species. The enzymatic process involves catalyzing the oxidative opening of the purine ring during the ...
      TIGR03383
      Location:8290
      urate_oxi; urate oxidase