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    Cnga4 cyclic nucleotide gated channel subunit alpha 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85258, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cnga4provided by RGD
    Official Full Name
    cyclic nucleotide gated channel subunit alpha 4provided by RGD
    Primary source
    RGD:619844
    See related
    EnsemblRapid:ENSRNOG00000017609 AllianceGenome:RGD:619844
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CNG4; CNG5; Cgn2; CNG-4; OCNC2; rOCNC2
    Summary
    Enables cGMP binding activity; intracellularly cAMP-activated cation channel activity; and intracellularly cGMP-activated cation channel activity. Involved in calcium ion transport; potassium ion transport; and sodium ion transport. Located in non-motile cilium membrane and perikaryon. Part of intracellular cyclic nucleotide activated cation channel complex. Orthologous to human CNGA4 (cyclic nucleotide gated channel subunit alpha 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 11.3), Heart (RPKM 1.1) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cnga4 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (169134332..169168317)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (159752357..159756369)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (170238959..170246858)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 52 subfamily B member 2 Neighboring gene similar to human chromosome 11 open reading frame 42 Neighboring gene olfactory receptor family 52 subfamily W member 1 Neighboring gene FHF complex subunit HOOK interacting protein 1B Neighboring gene uncharacterized LOC108349007 Neighboring gene cholecystokinin B receptor Neighboring gene caveolae associated protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A second subunit of the olfactory cyclic nucleotide-gated channel confers high sensitivity to cAMP. Liman ER, et al. Neuron, 1994 Sep. PMID 7522482
    2. Heteromeric olfactory cyclic nucleotide-gated channels: a subunit that confers increased sensitivity to cAMP. Bradley J, et al. Proc Natl Acad Sci U S A, 1994 Sep 13. PMID 7522325, Free PMC Article
    3. Deciphering the function of the CNGB1b subunit in olfactory CNG channels. Nache V, et al. Sci Rep, 2016 Jul 11. PMID 27405959, Free PMC Article
    4. Differential regulation by cyclic nucleotides of the CNGA4 and CNGB1b subunits in olfactory cyclic nucleotide-gated channels. Nache V, et al. Sci Signal, 2012 Jul 10. PMID 22786723
    5. Stoichiometry and assembly of olfactory cyclic nucleotide-gated channels. Zheng J, et al. Neuron, 2004 May 13. PMID 15134638

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cGMP activated olfactory CNG channels by binding to the two CNGA2 subunits and the CNGA4 subunit.
      Title: Differential regulation by cyclic nucleotides of the CNGA4 and CNGB1b subunits in olfactory cyclic nucleotide-gated channels.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cAMP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cGMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cGMP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cGMP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables intracellularly cAMP-activated cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables intracellularly cAMP-activated cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables intracellularly cGMP-activated cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables intracellularly cGMP-activated cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables intracellularly cGMP-activated cation channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-containing complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic cation transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sensory perception of smell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of intracellular cyclic nucleotide activated cation channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of intracellular cyclic nucleotide activated cation channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in non-motile cilium membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in non-motile cilium membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in non-motile cilium membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in non-motile cilium membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    cyclic nucleotide-gated channel alpha-4; cyclic nucleotide-gated cation channel alpha-4
    Names
    CNCalpha4 C
    CNG channel alpha-4
    cyclic nucleotide gated cation channel
    cyclic nucleotide gated channel alpha 4
    cyclic nucleotide-gated olfactory channel subunit OCNC2
    olfactory cyclic nucleotide-gated channel
    olfactory cyclic nucleotide-gated channel subunit 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053496.2 → NP_445948.2  cyclic nucleotide-gated channel alpha-4

      See identical proteins and their annotated locations for NP_445948.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001, U12623
      UniProtKB/Swiss-Prot
      Q64359, Q6Q2I4
      UniProtKB/TrEMBL
      A6I7I1, G3V898
      Related
      ENSRNOP00000023751.4, ENSRNOT00000023751.9
      Conserved Domains (5) summary
      COG0664
      Location:342 → 519
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:348 → 464
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:58 → 273
      Ion_trans; Ion transport protein
      pfam16526
      Location:464 → 535
      CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
      cl21455
      Location:116 → 174
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      169134332..169168317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275896.1 → XP_063131966.1  cyclic nucleotide-gated cation channel alpha-4 isoform X1

    2. XM_063275897.1 → XP_063131967.1  cyclic nucleotide-gated cation channel alpha-4 isoform X1

    3. XM_063275895.1 → XP_063131965.1  cyclic nucleotide-gated cation channel alpha-4 isoform X1

    4. XM_063275898.1 → XP_063131968.1  cyclic nucleotide-gated cation channel alpha-4 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64359.1 GenPept UniProtKB/Swiss-Prot:Q64359

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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