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    • Showing Current items.

    Itgb1 integrin subunit beta 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24511, updated on 3-Dec-2024

    Summary

    Symbol
    Itgb1provided by RGD
    Full Name
    integrin subunit beta 1provided by RGD
    Primary source
    RGD:2927
    See related
    EnsemblRapid:ENSRNOG00000010966 AllianceGenome:RGD:2927
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables several functions, including cytoskeletal protein binding activity; enzyme binding activity; and fibronectin binding activity. Involved in several processes, including bicellular tight junction assembly; regulation of cell projection organization; and regulation of neuron differentiation. Located in several cellular components, including acrosomal vesicle; focal adhesion; and hemidesmosome. Part of integrin alpha3-beta1 complex and integrin alpha9-beta1 complex. Is active in glutamatergic synapse; glycinergic synapse; and postsynaptic membrane. Used to study hydrocephalus and myocardial infarction. Biomarker of glomerulonephritis. Orthologous to human ITGB1 (integrin subunit beta 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 1593.5), Heart (RPKM 1215.7) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Itgb1 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (73602277..73650271)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (56705123..56753199)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (61677512..61725537)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548537 Neighboring gene neuropilin 1 Neighboring gene uncharacterized LOC134483666 Neighboring gene collagen alpha-1(I) chain-like Neighboring gene small nucleolar RNA SNORA17 Neighboring gene coiled-coil domain containing 7A Neighboring gene RNA, U4 small nuclear 86, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to C-X3-C chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to C-X3-C chemokine binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to C-X3-C chemokine binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables alpha-actinin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables collagen binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables collagen binding involved in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables collagen binding involved in cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    enables fibronectin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fibronectin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables fibronectin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables integrin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables integrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding involved in cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    enables integrin binding involved in cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding involved in cell-matrix adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to laminin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables laminin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables laminin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables laminin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    contributes_to laminin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in CD40 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in axon extension IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in basement membrane organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in basement membrane organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bicellular tight junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within calcium-independent cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac cell fate specification IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cardiac cell fate specification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cardiac muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac muscle cell myoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cardiac muscle cell myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell adhesion mediated by integrin IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell adhesion mediated by integrin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell migration involved in sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell projection organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to ionizing radiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to low-density lipoprotein particle stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to low-density lipoprotein particle stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to low-density lipoprotein particle stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to vitamin D IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in dendrite morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of Sertoli cell barrier IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in establishment of mitotic spindle orientation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in formation of radial glial scaffolds IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within formation of radial glial scaffolds ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in germ cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within germ cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leukocyte tethering or rolling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in maintenance of postsynaptic specialization structure EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in maintenance of postsynaptic specialization structure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in maternal process involved in female pregnancy IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in mesodermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in muscle organ development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in myoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in myoblast fate specification IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within myoblast fate specification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in myoblast fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of anoikis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell projection organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of vasoconstriction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of neuroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell-substrate adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glutamate uptake involved in transmission of nerve impulse IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of glutamate uptake involved in transmission of nerve impulse ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of neuroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of vascular endothelial growth factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein transport within lipid bilayer IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in reactive gliosis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within_negative_effect reactive gliosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor internalization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor internalization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of collagen catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of collagen catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within regulation of inward rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of postsynaptic neurotransmitter receptor diffusion trapping EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor diffusion trapping IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of spontaneous synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within_negative_effect regulation of spontaneous synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synapse pruning IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of synapse pruning ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to activity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to gonadotropin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to muscle activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to muscle activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to transforming growth factor beta IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in sarcomere organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within sarcomere organization ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synaptic membrane adhesion to extracellular matrix IC
    Inferred by Curator
    more info
     
    involved_in tissue homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in visual learning IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within visual learning ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cerebellar climbing fiber to Purkinje cell synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cerebellar climbing fiber to Purkinje cell synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in filopodium ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glial cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glycinergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in glycinergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in hemidesmosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of integrin alpha1-beta1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of integrin alpha10-beta1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of integrin alpha11-beta1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of integrin alpha2-beta1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of integrin alpha3-beta1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of integrin alpha3-beta1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of integrin alpha4-beta1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of integrin alpha5-beta1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of integrin alpha6-beta1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of integrin alpha7-beta1 complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of integrin alpha7-beta1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of integrin alpha9-beta1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of integrin alpha9-beta1 complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of integrin alpha9-beta1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of integrin alphav-beta1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of integrin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of integrin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intercalated disc IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intercalated disc ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myelin sheath abaxonal region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in myelin sheath abaxonal region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuromuscular junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    integrin beta-1
    Names
    VLA-4 subunit beta
    beta OL
    beta oligodendroglia
    collagen alpha-1(I) chain-like
    fibronectin receptor subunit beta
    integrin VLA-4 subunit beta
    integrin beta 1 (fibronectin receptor beta)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017022.2NP_058718.2  integrin beta-1 precursor

      See identical proteins and their annotated locations for NP_058718.2

      Status: VALIDATED

      Source sequence(s)
      BC131845
      UniProtKB/Swiss-Prot
      A2RRT8, P49134
      UniProtKB/TrEMBL
      A6KJ65
      Related
      ENSRNOP00000093150.2, ENSRNOT00000109602.2
      Conserved Domains (5) summary
      smart00187
      Location:34464
      INB; Integrin beta subunits (N-terminal portion of extracellular region)
      pfam07965
      Location:640727
      Integrin_B_tail; Integrin beta tail domain
      pfam08725
      Location:755795
      Integrin_b_cyt; Integrin beta cytoplasmic domain
      pfam18372
      Location:466495
      I-EGF_1; Integrin beta epidermal growth factor like domain 1
      NF033759
      Location:460650
      exchanger_TraA; outer membrane exchange protein TraA

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      73602277..73650271
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277783.1XP_063133853.1  integrin beta-1 isoform X1

      UniProtKB/Swiss-Prot
      A2RRT8, P49134
      UniProtKB/TrEMBL
      A0A0G2JSK5
      Related
      ENSRNOP00000014785.6, ENSRNOT00000014785.7