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    Spam1 sperm adhesion molecule 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117037, updated on 27-Nov-2024

    Summary

    Official Symbol
    Spam1provided by RGD
    Official Full Name
    sperm adhesion molecule 1provided by RGD
    Primary source
    RGD:620547
    See related
    EnsemblRapid:ENSRNOG00000007231 AllianceGenome:RGD:620547
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Spam
    Summary
    Predicted to enable hyalurononglucosaminidase activity. Predicted to be involved in hyaluronan catabolic process. Predicted to act upstream of or within single fertilization. Predicted to be located in external side of plasma membrane and membrane raft. Predicted to be active in acrosomal vesicle. Orthologous to human SPAM1 (sperm adhesion molecule 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 322.5) See more
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    Genomic context

    See Spam1 in Genome Data Viewer
    Location:
    4q22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (54268287..54278455)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (53302745..53312913)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (52194201..52204369)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene hyaluronoglucosaminidase 6 Neighboring gene hyaluronidase 4 Neighboring gene hyaluronoglucosaminidase 5 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene transmembrane protein 229A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC93268

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hyalurononglucosaminidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables hyalurononglucosaminidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in fusion of sperm to egg plasma membrane involved in single fertilization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in hyaluronan catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within single fertilization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in acrosomal vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    hyaluronidase PH-20
    Names
    hyal-PH20
    hyaluronoglucosaminidase PH-20
    sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
    sperm surface antigen 2B1
    sperm surface protein PH-20
    NP_446419.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053967.2NP_446419.1  hyaluronidase PH-20 precursor

      See identical proteins and their annotated locations for NP_446419.1

      Status: PROVISIONAL

      Source sequence(s)
      X89999
      UniProtKB/Swiss-Prot
      Q62803
      UniProtKB/TrEMBL
      A6IE93
      Related
      ENSRNOP00000009537.3, ENSRNOT00000009537.8
      Conserved Domains (1) summary
      pfam01630
      Location:42369
      Glyco_hydro_56; Hyaluronidase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      54268287..54278455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)