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    Rgs6 regulator of G-protein signaling 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54295, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rgs6provided by RGD
    Official Full Name
    regulator of G-protein signaling 6provided by RGD
    Primary source
    RGD:3569
    See related
    EnsemblRapid:ENSRNOG00000008082 AllianceGenome:RGD:3569
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables protein domain specific binding activity. Involved in positive regulation of neuron differentiation. Part of protein-containing complex. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human RGS6 (regulator of G protein signaling 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 93.2), Lung (RPKM 52.3) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rgs6 in Genome Data Viewer
    Location:
    6q24-q31
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (107875883..108527472)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (102264451..102796311)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (106310442..106598668)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene signal-induced proliferation-associated 1 like 1 Neighboring gene uncharacterized LOC134479448 Neighboring gene uncharacterized LOC102552965 Neighboring gene uncharacterized LOC134479449 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134479450 Neighboring gene polyadenylate-binding protein 1-like Neighboring gene uncharacterized LOC120093216 Neighboring gene uncharacterized LOC120093217 Neighboring gene double PHD fingers 3 Neighboring gene uncharacterized LOC134479225 Neighboring gene uncharacterized LOC134479227 Neighboring gene DDB1 and CUL4 associated factor 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RGS Proteins in Heart: Brakes on the Vagus. Stewart A, et al. Front Physiol, 2012. PMID 22685433, Free PMC Article
    2. RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6. Liu Z, et al. J Biol Chem, 2002 Oct 4. PMID 12140291
    3. Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways. Posner BA, et al. J Biol Chem, 1999 Oct 22. PMID 10521509
    4. Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain. Gold SJ, et al. J Neurosci, 1997 Oct 15. PMID 9315921, Free PMC Article
    5. An association study revealed substantial effects of dominance, epistasis and substance dependence co-morbidity on alcohol dependence symptom count. Chen G, et al. Addict Biol, 2017 Nov. PMID 27151647

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    regulator of G-protein signaling 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019342.1 → NP_062215.1  regulator of G-protein signaling 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6GJP9, F1LS67
      Related
      ENSRNOP00000054984.6, ENSRNOT00000058181.6
      Conserved Domains (3) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:328 → 452
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      107875883..108527472
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262367.1 → XP_063118437.1  regulator of G-protein signaling 6 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GJP9

    2. XM_063262368.1 → XP_063118438.1  regulator of G-protein signaling 6 isoform X4

      UniProtKB/TrEMBL
      A0A8I6GJP9
      Related
      ENSRNOP00000091512.2, ENSRNOT00000113156.2

    3. XM_063262369.1 → XP_063118439.1  regulator of G-protein signaling 6 isoform X5

      UniProtKB/TrEMBL
      A0A8I6GJP9

    4. XM_039112789.2 → XP_038968717.2  regulator of G-protein signaling 6 isoform X6

      UniProtKB/TrEMBL
      A0A8I6GJP9

    5. XM_039112787.2 → XP_038968715.2  regulator of G-protein signaling 6 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GJK3
      Related
      ENSRNOP00000091378.2, ENSRNOT00000107970.2

    6. XM_039112790.2 → XP_038968718.2  regulator of G-protein signaling 6 isoform X7

      UniProtKB/TrEMBL
      A0A8I6GJP9
      Related
      ENSRNOP00000085795.2, ENSRNOT00000114544.2

    7. XM_039112785.2 → XP_038968713.1  regulator of G-protein signaling 6 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G3X7, A0A8I6GJP9
      Related
      ENSRNOP00000069089.3, ENSRNOT00000086136.3
      Conserved Domains (4) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:328 → 452
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:116 → 217
      RGS_DHEX; Regulator of G-protein signalling DHEX domain

    8. XM_063262370.1 → XP_063118440.1  regulator of G-protein signaling 6 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G3X7, A0A8I6GJP9

    9. XM_039112783.2 → XP_038968711.1  regulator of G-protein signaling 6 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G3X7, A0A8I6GJP9
      Related
      ENSRNOP00000079945.1, ENSRNOT00000109319.2
      Conserved Domains (4) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:328 → 452
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:116 → 217
      RGS_DHEX; Regulator of G-protein signalling DHEX domain

    10. XM_039112784.2 → XP_038968712.1  regulator of G-protein signaling 6 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G3X7, A0A8I6GJP9
      Conserved Domains (4) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:328 → 452
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:116 → 217
      RGS_DHEX; Regulator of G-protein signalling DHEX domain

    RNA

    1. XR_005505572.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49801.1 GenPept UniProtKB/Swiss-Prot:P49801

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