Deptor DEP domain containing MTOR-interacting protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Deptorprovided by RGD
Full Name: DEP domain containing MTOR-interacting proteinprovided by RGD
Primary source: RGD:1561030
See related: EnsemblRapid:ENSRNOG00000004328 AllianceGenome:RGD:1561030
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Depdc6; RGD1561030
Summary: Predicted to enable phosphatidic acid binding activity and protein serine/threonine kinase inhibitor activity. Predicted to be involved in several processes, including negative regulation of TOR signaling; negative regulation of cell size; and negative regulation of protein kinase activity. Predicted to be active in lysosomal membrane. Orthologous to human DEPTOR (DEP domain containing MTOR interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 405.9), Kidney (RPKM 306.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q32

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (88404745..88574065)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (86514859..86668817)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (94795161..95000750)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mechanistically, DEPTOR inhibited both mTOR Complex 1 (mTORC1) and 2 (mTORC2) activities in PA cells. In addition, DEPTOR expression level was increased to suppress mTOR kinase activity via decreasing E3 ubiquitin ligase, betaTrCP1, in response to CAB.
Title: DEPTOR inhibits cell proliferation and confers sensitivity to dopamine agonist in pituitary adenoma.
Low DEPTOR expression is associated with glomerular mesangial cell hypertrophy.
Title: microRNA-181a downregulates deptor for TGFβ-induced glomerular mesangial cell hypertrophy and matrix protein expression.
Results illustrate the presence of DEPTOR in the rat brain and suggest a role for DEPTOR in the hypothalamic regulation of energy balance, which further supports the role of mTOR in energy homeostasis
Title: DEP domain-containing mTOR-interacting protein in the rat brain: distribution of expression and potential implication.

Submit: New GeneRIF Correction

General gene information

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Markers

D15Mit183 (e-PCR), detects polymorphism
- UniSTS:116433

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidic acid binding	ISO Inferred from Sequence Orthology more info
enables protein kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TORC2 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of TORC2 signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell size	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DEP domain-containing mTOR-interacting protein

Names: DEP domain containing 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427213.1 → NP_001414142.1 DEP domain-containing mTOR-interacting protein

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8I5ZQX9, A6HRG9, F1M8Y4

Related

ENSRNOP00000093077.2, ENSRNOT00000095532.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

88404745..88574065

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063263556.1 → XP_063119626.1 DEP domain-containing mTOR-interacting protein isoform X1

UniProtKB/TrEMBL

A0A8I6AIZ7

Related

ENSRNOP00000005722.7, ENSRNOT00000005722.10
XM_063263557.1 → XP_063119627.1 DEP domain-containing mTOR-interacting protein isoform X2
XM_017595234.3 → XP_017450723.1 DEP domain-containing mTOR-interacting protein isoform X3

Conserved Domains (2) summary

cd00992
Location:238 → 302

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl02442
Location:41 → 116

DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...