Kank1 KN motif and ankyrin repeat domains 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kank1provided by RGD
Official Full Name: KN motif and ankyrin repeat domains 1provided by RGD
Primary source: RGD:1307714
See related: EnsemblRapid:ENSRNOG00000016023 AllianceGenome:RGD:1307714
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ankrd15
Summary: Predicted to enable beta-catenin binding activity and protein-macromolecule adaptor activity. Predicted to be involved in several processes, including cytoskeleton organization; negative regulation of cellular component organization; and regulation of signal transduction. Predicted to be located in cell cortex; nucleus; and ruffle membrane. Predicted to be active in cytoplasm and cytoskeleton. Human ortholog(s) of this gene implicated in spastic quadriplegic cerebral palsy 2. Orthologous to human KANK1 (KN motif and ankyrin repeat domains 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 116.4), Kidney (RPKM 109.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q51

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (232381720..232500834)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (222877962..223074514)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (243201073..243398531)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In rats, KANK1, KANK2, and KANK4 all localized to podocytes in glomeruli, and KANK1 partially colocalized with synaptopodin.
Title: KANK deficiency leads to podocyte dysfunction and nephrotic syndrome.

Submit: New GeneRIF Correction

General gene information

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Markers

RH133058 (e-PCR)
- UniSTS:216341

D1Rat223 (e-PCR), detects polymorphism
- UniSTS:118562

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cortical microtubule organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lamellipodium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ruffle assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in podocyte cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of wound healing	ISO Inferred from Sequence Orthology more info
involved_in regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of establishment of cell polarity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell cortex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: KN motif and ankyrin repeat domain-containing protein 1

Names: ankyrin repeat domain 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037197.2 → NP_001032274.2 KN motif and ankyrin repeat domain-containing protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6AL84

Related

ENSRNOP00000089539.1, ENSRNOT00000107412.2

Conserved Domains (5) summary

cd00204
Location:1164 → 1295

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12075
Location:30 → 68

KN_motif; KN motif

pfam12796
Location:1174 → 1272

Ank_2; Ankyrin repeats (3 copies)

pfam13857
Location:1261 → 1316

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:1242 → 1272

ANK; ANK repeat [structural motif]