Slc10a1 solute carrier family 10 member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc10a1provided by RGD
Official Full Name: solute carrier family 10 member 1provided by RGD
Primary source: RGD:3681
See related: EnsemblRapid:ENSRNOG00000005794 AllianceGenome:RGD:3681
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ntcp; Ntcp1; SBACT
Summary: Enables bile acid:sodium symporter activity. Involved in several processes, including bile acid and bile salt transport; response to estrogen; and response to ethanol. Located in basolateral plasma membrane. Biomarker of alcoholic hepatitis; cholestasis; and obesity. Orthologous to human SLC10A1 (solute carrier family 10 member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 1798.3) and Lung (RPKM 54.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 6q24

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (106344319..106357944, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (100613045..100626670, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (104617730..104631355, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structure of the bile acid transporter and HBV receptor NTCP.
Title: Structure of the bile acid transporter and HBV receptor NTCP.
The present study suggests that glycochenodeoxycholate triggers the retrieval of Ntcp from the basolateral membrane into the cytosol through an oxidative stress-dependent activation of Fyn.
Title: Regulation of Plasma Membrane Localization of the Na⁺-Taurocholate Co-Transporting Polypeptide by Glycochenodeoxycholate and Tauroursodeoxycholate.
Administration of glucocorticoids (GCs) enhanced liver bile acid uptake by increasing the expression of the major hepatocyte basolateral bile transporter (Ntcp)in rats. The reduced expression of a bile acid synthesis rate-controlling enzyme, Cyp7a1, suggests that treatment with GCs suppressed hepatic bile acid synthesis.
Title: Glucocorticoid treatment alters systemic bile acid homeostasis by regulating the biosynthesis and transport of bile salts.
Ntcp plasma membrane localization is regulated by hyperosmolarity and tauroursodeoxycholate
Title: Regulation of plasma membrane localization of the Na+-taurocholate cotransporting polypeptide (Ntcp) by hyperosmolarity and tauroursodeoxycholate.
Taurocholate (TCA) for Ntcp.
Title: Age-dependent activity of the uptake transporters Ntcp and Oatp1b2 in male rat hepatocytes: from birth till adulthood.
This study identified a motif which is critical for Ntcp plasma membrane localization.
Title: A dileucine motif is involved in plasma membrane expression and endocytosis of rat sodium taurocholate cotransporting polypeptide (Ntcp).
hepatic transporters Ntcp and Mrp2 are downregulated in rodent models of necrotizing enterocolitis
Title: The hepatic bile acid transporters Ntcp and Mrp2 are downregulated in experimental necrotizing enterocolitis.
sustained repression and translocation of Ntcp and the expression of Mrp4 at the basolateral membrane seem to be responsible for the high blood bile acids levels after massive hepatectomy
Title: Sustained repression and translocation of Ntcp and expression of Mrp4 for cholestasis after rat 90% partial hepatectomy.
Ca(2+)-dependent PKCs induce vesicular retrieval of Ntcp, thereby reducing bile salt uptake. Short-term downregulation of Ntcp by endocytosis may be important mechanism to protect hepatocytes from effects of toxic intracellular bile salt concentrations.
Title: Protein kinase C induces endocytosis of the sodium taurocholate cotransporting polypeptide.
Report PKCepsilon-dependent and -independent effects of taurolithocholate on PI3K/PKB pathway and taurocholate uptake in HuH-NTCP cell line.
Title: PKC{epsilon}-dependent and -independent effects of taurolithocholate on PI3K/PKB pathway and taurocholate uptake in HuH-NTCP cell line.

Submit: New GeneRIF Correction See all GeneRIFs (24)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables bile acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables bile acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables bile acid:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables bile acid:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables bile acid:sodium symporter activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in bile acid and bile salt transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in bile acid and bile salt transport	IDA Inferred from Direct Assay more info	PubMed
involved_in bile acid and bile salt transport	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: hepatic sodium/bile acid cotransporter

Names: NA-dependent cholate transporting protein; Na(+)/bile acid cotransporter; Na(+)/taurocholate transport protein; sodium-dependent bile acid cotransporter; sodium-dependent taurocholate cotransporting polypeptide; sodium/bile acid cotransporter; sodium/taurocholate cotransporting polypeptide; solute carrier family 10 (sodium/bile acid cotransporter family), member 1; solute carrier family 10 (sodium/bile acid cotransporter), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.