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    Spo11 SPO11 initiator of meiotic double stranded breaks [ Mus musculus (house mouse) ]

    Gene ID: 26972, updated on 9-Dec-2024

    Summary

    Official Symbol
    Spo11provided by MGI
    Official Full Name
    SPO11 initiator of meiotic double stranded breaksprovided by MGI
    Primary source
    MGI:MGI:1349669
    See related
    Ensembl:ENSMUSG00000005883 AllianceGenome:MGI:1349669
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Spo11a; Spo11b
    Summary
    Predicted to enable DNA binding activity. Acts upstream of or within several processes, including germ cell development; meiosis I; and ovarian follicle development. Located in chromosome, telomeric region. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; liver; oral epithelium; and skin. Orthologous to human SPO11 (SPO11 initiator of meiotic double strand breaks). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in thymus adult (RPKM 21.9) and testis adult (RPKM 15.7) See more
    Orthologs
    NEW
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    Genomic context

    See Spo11 in Genome Data Viewer
    Location:
    2 H3; 2 95.64 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (172819172..172835369)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (172977379..172993576)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700055K11 gene Neighboring gene predicted gene, 36254 Neighboring gene VISTA enhancer mm75 Neighboring gene STARR-seq mESC enhancer starr_06603 Neighboring gene STARR-seq mESC enhancer starr_06604 Neighboring gene bone morphogenetic protein 7 Neighboring gene enhancer in intron 1 of Bmp7 Neighboring gene predicted gene, 40010 Neighboring gene STARR-positive B cell enhancer ABC_E4526 Neighboring gene predicted gene, 52538 Neighboring gene STARR-positive B cell enhancer ABC_E6029 Neighboring gene STARR-seq mESC enhancer starr_06607 Neighboring gene ribonucleic acid export 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:172852363-172852564 Neighboring gene RNA binding motif protein 38

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA negative supercoiling activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within double-strand break repair involved in meiotic recombination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within homologous chromosome pairing at meiosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within leptotene IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within male meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in meiotic DNA double-strand break formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in meiotic DNA double-strand break formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in meiotic DNA double-strand break processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within meiotic telomere clustering IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ovarian follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein localization to chromosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within synaptonemal complex assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within synaptonemal complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nuclear chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    meiotic recombination protein SPO11
    Names
    SPO11 meiotic protein covalently bound to DSB homolog
    sporulation protein, meiosis-specific, SPO11 homolog (S. cervisiae)
    NP_001077428.1
    NP_001077429.1
    NP_001292363.1
    NP_001399399.1
    NP_036176.1
    XP_006499680.1
    XP_006499681.1
    XP_006499682.1
    XP_006499683.1
    XP_006499685.1
    XP_036018140.1
    XP_036018141.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083959.2NP_001077428.1  meiotic recombination protein SPO11 isoform c

      See identical proteins and their annotated locations for NP_001077428.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region and uses an alternate in-frame splice site in an internal exon compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AL928599, AL929140
      Consensus CDS
      CCDS50811.1
      UniProtKB/Swiss-Prot
      Q9WTK8
      Related
      ENSMUSP00000104754.4, ENSMUST00000109126.5
      Conserved Domains (3) summary
      cd00223
      Location:193355
      TOPRIM_TopoIIB_SPO; TOPRIM_TopoIIB_SPO: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IIB family of DNA topoisomerases and Spo11. This subgroup contains proteins similar to Sulfolobus shibatae topoisomerase VI (TopoVI) ...
      pfam03533
      Location:243
      SPO11_like; SPO11 homologue
      pfam04406
      Location:69145
      TP6A_N; Type IIB DNA topoisomerase
    2. NM_001083960.2NP_001077429.1  meiotic recombination protein SPO11 isoform b

      See identical proteins and their annotated locations for NP_001077429.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AL928599, AL929140
      Consensus CDS
      CCDS50812.1
      UniProtKB/Swiss-Prot
      Q9WTK8
      Related
      ENSMUSP00000104753.2, ENSMUST00000109125.8
      Conserved Domains (3) summary
      cd00223
      Location:180342
      TOPRIM_TopoIIB_SPO; TOPRIM_TopoIIB_SPO: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IIB family of DNA topoisomerases and Spo11. This subgroup contains proteins similar to Sulfolobus shibatae topoisomerase VI (TopoVI) ...
      pfam03533
      Location:243
      SPO11_like; SPO11 homologue
      pfam04406
      Location:69132
      TP6A_N; Type IIB DNA topoisomerase
    3. NM_001305434.2NP_001292363.1  meiotic recombination protein SPO11 isoform d

      See identical proteins and their annotated locations for NP_001292363.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region and uses an alternate in-frame splice site at an internal exon compared to variant 1. It encodes isoform d, which is shorter than isoform a.
      Source sequence(s)
      AL928599, AL929140
      UniProtKB/Swiss-Prot
      Q9WTK8
      Conserved Domains (3) summary
      cd00223
      Location:176338
      TOPRIM_TopoIIB_SPO; TOPRIM_TopoIIB_SPO: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IIB family of DNA topoisomerases and Spo11. This subgroup contains proteins similar to Sulfolobus shibatae topoisomerase VI (TopoVI) ...
      pfam03533
      Location:243
      SPO11_like; SPO11 homologue
      pfam04406
      Location:69132
      TP6A_N; Type IIB DNA topoisomerase
    4. NM_001412470.1NP_001399399.1  meiotic recombination protein SPO11 isoform e

      Status: VALIDATED

      Source sequence(s)
      AL928599, AL929140
    5. NM_012046.3NP_036176.1  meiotic recombination protein SPO11 isoform a

      See identical proteins and their annotated locations for NP_036176.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AL928599, AL929140
      Consensus CDS
      CCDS17137.1
      UniProtKB/Swiss-Prot
      Q8VIH6, Q9QUK2, Q9QY57, Q9QZS1, Q9WTK8
      Related
      ENSMUSP00000059056.10, ENSMUST00000050442.15
      Conserved Domains (4) summary
      cd00223
      Location:218380
      TOPRIM_TopoIIB_SPO; TOPRIM_TopoIIB_SPO: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IIB family of DNA topoisomerases and Spo11. This subgroup contains proteins similar to Sulfolobus shibatae topoisomerase VI (TopoVI) ...
      PRK04342
      Location:42396
      PRK04342; DNA topoisomerase VI subunit A; Provisional
      pfam03533
      Location:244
      SPO11_like; SPO11 homologue
      pfam04406
      Location:107170
      TP6A_N; Type IIB DNA topoisomerase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      172819172..172835369
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499620.4XP_006499683.1  meiotic recombination protein SPO11 isoform X4

      Conserved Domains (1) summary
      PRK04342
      Location:16376
      PRK04342; DNA topoisomerase IV subunit A
    2. XM_036162248.1XP_036018141.1  meiotic recombination protein SPO11 isoform X7

      Conserved Domains (1) summary
      cd00223
      Location:34196
      TOPRIM_TopoIIB_SPO; topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IIB family of DNA topoisomerases and Spo11. This subgroup contains proteins similar to Sulfolobus shibatae topoisomerase VI (TopoVI) and Saccharomyces ...
    3. XM_006499618.4XP_006499681.1  meiotic recombination protein SPO11 isoform X2

      Conserved Domains (2) summary
      PRK04342
      Location:42462
      PRK04342; DNA topoisomerase IV subunit A
      pfam03533
      Location:244
      SPO11_like; SPO11 homolog
    4. XM_006499617.4XP_006499680.1  meiotic recombination protein SPO11 isoform X1

      Conserved Domains (2) summary
      PRK04342
      Location:42466
      PRK04342; DNA topoisomerase IV subunit A
      pfam03533
      Location:244
      SPO11_like; SPO11 homolog
    5. XM_006499619.4XP_006499682.1  meiotic recombination protein SPO11 isoform X3

      Conserved Domains (2) summary
      PRK04342
      Location:68428
      PRK04342; DNA topoisomerase IV subunit A
      pfam03533
      Location:243
      SPO11_like; SPO11 homolog
    6. XM_036162247.1XP_036018140.1  meiotic recombination protein SPO11 isoform X6

      Conserved Domains (1) summary
      cd00223
      Location:34266
      TOPRIM_TopoIIB_SPO; topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IIB family of DNA topoisomerases and Spo11. This subgroup contains proteins similar to Sulfolobus shibatae topoisomerase VI (TopoVI) and Saccharomyces ...
    7. XM_006499622.3XP_006499685.1  meiotic recombination protein SPO11 isoform X5

      Conserved Domains (1) summary
      cd00223
      Location:59291
      TOPRIM_TopoIIB_SPO; topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IIB family of DNA topoisomerases and Spo11. This subgroup contains proteins similar to Sulfolobus shibatae topoisomerase VI (TopoVI) and Saccharomyces ...