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    Garem1 GRB2 associated regulator of MAPK1 subtype 1 [ Mus musculus (house mouse) ]

    Gene ID: 381126, updated on 9-Dec-2024

    Summary

    Official Symbol
    Garem1provided by MGI
    Official Full Name
    GRB2 associated regulator of MAPK1 subtype 1provided by MGI
    Primary source
    MGI:MGI:2685790
    See related
    Ensembl:ENSMUSG00000042680 AllianceGenome:MGI:2685790
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Garem; Gm944; Fam59a; mKIAA4238
    Summary
    Predicted to enable proline-rich region binding activity. Predicted to be involved in several processes, including cellular response to epidermal growth factor stimulus; epidermal growth factor receptor signaling pathway; and positive regulation of ERK1 and ERK2 cascade. Is expressed in central nervous system; heart; lung; metanephros; and skeletal musculature. Orthologous to human GAREM1 (GRB2 associated regulator of MAPK1 subtype 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 4.4), frontal lobe adult (RPKM 4.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Garem1 in Genome Data Viewer
    Location:
    18 A2; 18 11.87 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (21257916..21433196, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (21127342..21300139, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3224 Neighboring gene STARR-seq mESC enhancer starr_43999 Neighboring gene ring finger protein 138 Neighboring gene STARR-seq mESC enhancer starr_44001 Neighboring gene STARR-seq mESC enhancer starr_44006 Neighboring gene STARR-seq mESC enhancer starr_44007 Neighboring gene meprin 1 beta Neighboring gene ribosomal protein L27A pseudogene Neighboring gene STARR-seq mESC enhancer starr_44011 Neighboring gene predicted gene, 41675 Neighboring gene predicted gene 7758

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Clone Names

    • KIAA4238

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables proline-rich region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables proline-rich region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables proline-rich region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in cellular response to epidermal growth factor stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to epidermal growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to epidermal growth factor stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epidermal growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of protein kinase activity by regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of_or_within response to epidermal growth factor ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    GRB2-associated and regulator of MAPK protein
    Names
    GRB2 associated, regulator of MAPK1
    GRB2-associated and regulator of MAPK1
    family with sequence similarity 59, member A
    protein FAM59A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033445.3NP_001028617.2  GRB2-associated and regulator of MAPK protein

      See identical proteins and their annotated locations for NP_001028617.2

      Status: VALIDATED

      Source sequence(s)
      AC127570, AC158774
      Consensus CDS
      CCDS29091.1
      UniProtKB/Swiss-Prot
      G5E8B7, Q3TSA2, Q3UFT3, Q5DTF6, Q80V96
      Related
      ENSMUSP00000048914.7, ENSMUST00000049260.7
      Conserved Domains (2) summary
      cd09525
      Location:808874
      SAM_GAREM; SAM domain of GAREM subfamily
      pfam12736
      Location:32323
      CABIT; Cell-cycle sustaining, positive selection,

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      21257916..21433196 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)