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    Zfp382 zinc finger protein 382 [ Mus musculus (house mouse) ]

    Gene ID: 233060, updated on 21-Dec-2024

    Summary

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    Official Symbol
    Zfp382provided by MGI
    Official Full Name
    zinc finger protein 382provided by MGI
    Primary source
    MGI:MGI:3588204
    See related
    Ensembl:ENSMUSG00000074220 AllianceGenome:MGI:3588204
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KS1; Znf382; 4930428B01Rik; 5930415A09Rik
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZNF382 (zinc finger protein 382). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 2.8), testis adult (RPKM 2.3) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp382 in Genome Data Viewer
    Location:
    7; 7 B1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29821255..29840180)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30121833..30140758)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18504 Neighboring gene zinc finger protein 566 Neighboring gene STARR-positive B cell enhancer ABC_E869 Neighboring gene zinc finger protein 260 Neighboring gene STARR-seq mESC enhancer starr_18505 Neighboring gene STARR-seq mESC enhancer starr_18508 Neighboring gene zinc finger protein 334 pseudogene Neighboring gene STARR-seq mESC enhancer starr_18509 Neighboring gene zinc finger protein 146

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons. Ma L, et al. J Exp Med, 2021 Dec 6. PMID 34762123, Free PMC Article
    2. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
    3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons.
      Title: ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 382
    Names
    KRAB/zinc finger suppressor protein 1
    multiple zinc finger and krueppel-associated box protein KS1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081007.2 → NP_001074476.1  zinc finger protein 382 isoform 1

      See identical proteins and their annotated locations for NP_001074476.1

      Status: VALIDATED

      Source sequence(s)
      AC164703
      Consensus CDS
      CCDS39877.1
      UniProtKB/Swiss-Prot
      B2RXC5, Q3UYY9
      Related
      ENSMUSP00000096196.4, ENSMUST00000098596.11
      Conserved Domains (6) summary
      smart00349
      Location:42 → 102
      KRAB; krueppel associated box
      COG5048
      Location:411 → 562
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:411 → 431
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:523 → 543
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:42 → 81
      KRAB; KRAB box
      pfam13465
      Location:535 → 560
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001362158.1 → NP_001349087.1  zinc finger protein 382 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC164703
      Conserved Domains (3) summary
      smart00349
      Location:42 → 102
      KRAB; krueppel associated box
      COG5048
      Location:410 → 561
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:410 → 430
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001362159.1 → NP_001349088.1  zinc finger protein 382 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC164703
      Conserved Domains (3) summary
      smart00349
      Location:12 → 72
      KRAB; krueppel associated box
      COG5048
      Location:381 → 532
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:381 → 401
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      29821255..29840180
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017322166.3 → XP_017177655.1  zinc finger protein 382 isoform X1

      Conserved Domains (4) summary
      smart00349
      Location:12 → 72
      KRAB; krueppel associated box
      COG5048
      Location:380 → 531
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:380 → 400
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:294 → 316
      zf-C2H2; Zinc finger, C2H2 type
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2RXC5.1 GenPept UniProtKB/Swiss-Prot:B2RXC5

    Gene LinkOut

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