Tapbpl TAP binding protein-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tapbplprovided by MGI
Official Full Name: TAP binding protein-likeprovided by MGI
Primary source: MGI:MGI:2384853
See related: Ensembl:ENSMUSG00000038213 AllianceGenome:MGI:2384853
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tapbplr; TAPBPL-R
Summary: Predicted to enable MHC class I protein complex binding activity and TAP complex binding activity. Predicted to be involved in negative regulation of antigen processing and presentation of peptide antigen via MHC class I and peptide antigen assembly with MHC class I protein complex. Predicted to be located in endoplasmic reticulum. Predicted to be part of MHC class I peptide loading complex. Orthologous to human TAPBPL (TAP binding protein like). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in thymus adult (RPKM 16.5), large intestine adult (RPKM 16.3) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F3; 6 59.32 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (125200890..125208823, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (125223927..125231860, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Focuses on cloning and characterization of human TAPBP-R but also identifies the mouse ortholog Tapbpl.
Title: A human TAPBP (TAPASIN)-related gene, TAPBP-R.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tnfrsf7 (e-PCR), detects polymorphism
- UniSTS:144658

Tnfrsf7 (e-PCR), detects polymorphism
- UniSTS:144659

D11Bhm20 (e-PCR), detects polymorphism
- UniSTS:141619

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MHC class I protein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables MHC class I protein complex binding	IEA Inferred from Electronic Annotation more info
enables MHC class I protein complex binding	ISO Inferred from Sequence Orthology more info
enables TAP complex binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of antigen processing and presentation of peptide antigen via MHC class I	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of antigen processing and presentation of peptide antigen via MHC class I	ISO Inferred from Sequence Orthology more info
involved_in peptide antigen assembly with MHC class I protein complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptide antigen assembly with MHC class I protein complex	IEA Inferred from Electronic Annotation more info
involved_in peptide antigen assembly with MHC class I protein complex	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
part_of MHC class I peptide loading complex	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tapasin-related protein

Names: TAP-binding protein-related protein; TAPASIN-R; TAPBP-R; tapasin-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145391.2 → NP_663366.2 tapasin-related protein precursor

See identical proteins and their annotated locations for NP_663366.2

Status: VALIDATED

Source sequence(s)

AA762569, AC140324, BC094656, BX517366

Consensus CDS

CCDS20547.1

UniProtKB/Swiss-Prot

E9QN33, Q8VD31

Related

ENSMUSP00000047105.8, ENSMUST00000043422.8

Conserved Domains (3) summary

smart00410
Location:209 → 299

IG_like; Immunoglobulin like

pfam07686
Location:209 → 306

V-set; Immunoglobulin V-set domain

cl11960
Location:271 → 401

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

125200890..125208823 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030255302.2 → XP_030111162.1 tapasin-related protein isoform X1

Conserved Domains (2) summary

pfam07686
Location:202 → 289

V-set; Immunoglobulin V-set domain

cl11960
Location:264 → 394

Ig; Immunoglobulin domain