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    Commd9 COMM domain containing 9 [ Mus musculus (house mouse) ]

    Gene ID: 76501, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Commd9provided by MGI
    Official Full Name
    COMM domain containing 9provided by MGI
    Primary source
    MGI:MGI:1923751
    See related
    Ensembl:ENSMUSG00000027163 AllianceGenome:MGI:1923751
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810029F08Rik
    Summary
    Acts upstream of or within cholesterol homeostasis. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and skeleton. Orthologous to human COMMD9 (COMM domain containing 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 24.5), whole brain E14.5 (RPKM 24.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Commd9 in Genome Data Viewer
    Location:
    2 E2; 2 54.07 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (101716607..101731984)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (101886262..101901639)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5948 Neighboring gene TNF receptor-associated factor 6 Neighboring gene STARR-positive B cell enhancer ABC_E5949 Neighboring gene STARR-seq mESC enhancer starr_05236 Neighboring gene proline rich 5 like Neighboring gene STARR-seq mESC enhancer starr_05237 Neighboring gene STARR-positive B cell enhancer ABC_E2043 Neighboring gene STARR-seq mESC enhancer starr_05238 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:101819193-101819405 Neighboring gene low density lipoprotein receptor class A domain containing 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:101831937-101832164 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:101833086-101833410 Neighboring gene predicted gene, 39888 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:101870916-101871189 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:101879569-101879838 Neighboring gene predicted gene, 54138

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of murine copper homeostasis by members of the COMMD protein family. Singla A, et al. Dis Model Mech, 2021 Jan 1. PMID 33262129, Free PMC Article
    2. Microbial Sensing by Intestinal Myeloid Cells Controls Carcinogenesis and Epithelial Differentiation. Miyata N, et al. Cell Rep, 2018 Aug 28. PMID 30157428, Free PMC Article
    3. The COMMD Family Regulates Plasma LDL Levels and Attenuates Atherosclerosis Through Stabilizing the CCC Complex in Endosomal LDLR Trafficking. Fedoseienko A, et al. Circ Res, 2018 Jun 8. PMID 29545368
    4. Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling. Li H, et al. J Cell Biol, 2015 Nov 9. PMID 26553930, Free PMC Article
    5. CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL. Bartuzi P, et al. Nat Commun, 2016 Mar 11. PMID 26965651, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Increased total plasma cholesterol levels are seen in hepatic COMMD9-deficient mice.
      Title: CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    COMM domain-containing protein 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029635.3 → NP_083911.1  COMM domain-containing protein 9

      See identical proteins and their annotated locations for NP_083911.1

      Status: PROVISIONAL

      Source sequence(s)
      AL929534
      Consensus CDS
      CCDS16465.1
      UniProtKB/Swiss-Prot
      Q3U3J2, Q7TNP5, Q811K2, Q8K2Q0, Q9D8V8
      Related
      ENSMUSP00000028584.8, ENSMUST00000028584.8
      Conserved Domains (2) summary
      cd04757
      Location:90 → 197
      Commd9; COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...
      pfam03081
      Location:10 → 146
      Exo70; Exo70 exocyst complex subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      101716607..101731984
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K2Q0.3 GenPept UniProtKB/Swiss-Prot:Q8K2Q0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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