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    ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 [ Homo sapiens (human) ]

    Gene ID: 50807, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ASAP1provided by HGNC
    Official Full Name
    ArfGAP with SH3 domain, ankyrin repeat and PH domain 1provided by HGNC
    Primary source
    HGNC:HGNC:2720
    See related
    Ensembl:ENSG00000153317 MIM:605953; AllianceGenome:HGNC:2720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAP; PAG2; AMAP1; DDEF1; ZG14P; CENTB4
    Summary
    This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
    Expression
    Ubiquitous expression in bone marrow (RPKM 18.3), spleen (RPKM 15.5) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ASAP1 in Genome Data Viewer
    Location:
    8q24.21-q24.22
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (130052104..130443674, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (131178779..131571038, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (131064350..131455920, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene CYFIP related Rac1 interactor B Neighboring gene uncharacterized LOC124902025 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19542 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19543 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19544 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19545 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:131054337-131055152 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27979 Neighboring gene RNA, U7 small nuclear 181 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr8:131067248-131067450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:131081877-131082759 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27980 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:131098365-131098897 Neighboring gene microRNA 5194 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:131110363-131110520 Neighboring gene RNA, U6 small nuclear 1255, pseudogene Neighboring gene ASAP1 intronic transcript 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27981 Neighboring gene small nucleolar RNA SNORA12 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:131216140-131217109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27982 Neighboring gene uncharacterized LOC124902027 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27983 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27984 Neighboring gene NANOG hESC enhancer GRCh37_chr8:131323031-131323532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27985 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27986 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19546 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:131345596-131346175 Neighboring gene ASAP1 intronic transcript 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:131370073-131371035 Neighboring gene uncharacterized LOC124902026 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:131380037-131380536 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:131388200-131388776 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:131431296-131431799 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19551 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19552 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19553 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19554 Neighboring gene Sharpr-MPRA regulatory region 3250 Neighboring gene uncharacterized LOC105375758 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:131540148-131541347 Neighboring gene NFE2L2 motif-containing MPRA enhancer 239 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27987 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27988 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_101181 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:131739458-131740657 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:131759497-131759683 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19555 Neighboring gene uncharacterized LOC105375762 Neighboring gene adenylate cyclase 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Regulation of ASAP1 by phospholipids is dependent on the interface between the PH and Arf GAP domains. Che MM, et al. Cell Signal, 2005 Oct. PMID 16038802
    2. Integrative analysis of genomic amplification-dependent expression and loss-of-function screen identifies ASAP1 as a driver gene in triple-negative breast cancer progression. He J, et al. Oncogene, 2020 May. PMID 32235890, Free PMC Article
    3. The BAR domain of the Arf GTPase-activating protein ASAP1 directly binds actin filaments. Chen PW, et al. J Biol Chem, 2020 Aug 7. PMID 32444496, Free PMC Article
    4. IRES-mediated translational control of AMAP1 expression during differentiation of monocyte U937 cells. Miyata M, et al. Cell Cycle, 2008 Oct. PMID 18843202
    5. Autoinhibition of Arf GTPase-activating protein activity by the BAR domain in ASAP1. Jian X, et al. J Biol Chem, 2009 Jan 16. PMID 19017632, Free PMC Article

    See all (104) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-212/132 attenuates OVA-induced airway inflammation by inhibiting mast cells activation through MRGPRX2 and ASAP1.
      Title: miR-212/132 attenuates OVA-induced airway inflammation by inhibiting mast cells activation through MRGPRX2 and ASAP1.
    2. ASAP1 Expression in Invasive Breast Cancer and Its Prognostic Role.
      Title: ASAP1 Expression in Invasive Breast Cancer and Its Prognostic Role.
    3. An Uncharacterised lncRNA Coded by the ASAP1 Locus Is Downregulated in Serum of Type 2 Diabetes Mellitus Patients.
      Title: An Uncharacterised lncRNA Coded by the ASAP1 Locus Is Downregulated in Serum of Type 2 Diabetes Mellitus Patients.
    4. ASAP1 activates the IQGAP1/CDC42 pathway to promote tumor progression and chemotherapy resistance in gastric cancer.
      Title: ASAP1 activates the IQGAP1/CDC42 pathway to promote tumor progression and chemotherapy resistance in gastric cancer.
    5. Polymorphisms in the ASAP1 and SP110 Genes and Its Association with the Susceptibility to Pulmonary Tuberculosis in a Mongolian Population.
      Title: Polymorphisms in the ASAP1 and SP110 Genes and Its Association with the Susceptibility to Pulmonary Tuberculosis in a Mongolian Population.
    6. Clinicopathological Implications of ASAP1 Expression in Hepatocellular Carcinoma.
      Title: Clinicopathological Implications of ASAP1 Expression in Hepatocellular Carcinoma.
    7. Loss of ASAP1 in the MMTV-PyMT model of luminal breast cancer activates AKT, accelerates tumorigenesis, and promotes metastasis.
      Title: Loss of ASAP1 in the MMTV-PyMT model of luminal breast cancer activates AKT, accelerates tumorigenesis, and promotes metastasis.
    8. ASAP1 regulates the uptake of Mycobacterium tuberculosis H37Ra in THP1-derived macrophages by remodeling actin cytoskeleton.
      Title: ASAP1 regulates the uptake of Mycobacterium tuberculosis H37Ra in THP1-derived macrophages by remodeling actin cytoskeleton.
    9. High expression of AMAP1, an ARF6 effector, is associated with elevated levels of PD-L1 and fibrosis of pancreatic cancer.
      Title: High expression of AMAP1, an ARF6 effector, is associated with elevated levels of PD-L1 and fibrosis of pancreatic cancer.
    10. Circular RNA Sequencing Identifies CircASAP1 as a Key Regulator in Hepatocellular Carcinoma Metastasis.
      Title: Circular RNA Sequencing Identifies CircASAP1 as a Key Regulator in Hepatocellular Carcinoma Metastasis.
    Submit: New GeneRIF Correction See all GeneRIFs (44)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1249

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cadherin binding HDA PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylserine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane protein transport IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of dendritic spine development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cilium assembly IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in positive regulation of membrane tubulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynapse organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in podosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
    Names
    130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein
    130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein
    ADP-ribosylation factor-directed GTPase-activating protein 1
    ARF GTPase-activating protein 1
    DEF-1
    PIP2-dependent ARF1 GAP
    centaurin, beta 4
    development and differentiation-enhancing factor 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030354.1 RefSeqGene

      Range
      4987..396557
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001247996.2 → NP_001234925.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001234925.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an additional exon (with an in-frame AUG) in the 5' region compared to variant 1. This results in translation initiation from an alternate start site, and a shorter isoform (2) with a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AB033075, AI494058, AP005856, BC144493, DA319233
      Consensus CDS
      CCDS75788.1
      UniProtKB/TrEMBL
      A0A0A0MRE5, H0YBF7
      Related
      ENSP00000350297.2, ENST00000357668.2
      Conserved Domains (8) summary
      cd07641
      Location:47 → 261
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:1064 → 1120
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      cd00204
      Location:594 → 682
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:309 → 415
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      pfam00169
      Location:319 → 404
      PH; PH domain
      pfam01412
      Location:432 → 548
      ArfGap; Putative GTPase activating protein for Arf
      pfam12796
      Location:575 → 660
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:594 → 627
      ANK; ANK repeat [structural motif]

    2. NM_001362924.1 → NP_001349853.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AB033075, AI494058, BC144493, BQ645913, DA315979, DA319233, DA416332
      UniProtKB/TrEMBL
      H0YBF7
      Conserved Domains (7) summary
      cd07641
      Location:54 → 268
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:1074 → 1130
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      cd00204
      Location:604 → 692
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:319 → 425
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:604 → 637
      ANK; ANK repeat [structural motif]
      pfam01412
      Location:442 → 558
      ArfGap; Putative GTPase activating protein for Arf
      cl26464
      Location:727 → 1063
      Atrophin-1; Atrophin-1 family

    3. NM_001362925.2 → NP_001349854.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AB033075, AI494058, AP005856, BC144493, BG748866, DA315979, DA319233, DA416332
      UniProtKB/TrEMBL
      H0YBF7
      Conserved Domains (7) summary
      cd07641
      Location:54 → 268
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:1017 → 1073
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      cd00204
      Location:604 → 692
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:319 → 425
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:604 → 637
      ANK; ANK repeat [structural motif]
      pfam01412
      Location:442 → 558
      ArfGap; Putative GTPase activating protein for Arf
      cl26464
      Location:730 → 1006
      Atrophin-1; Atrophin-1 family

    4. NM_001362926.2 → NP_001349855.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AB033075, AI494058, AP005856, BC144493, BG118567, BG748866, DA315979, DA319233, DA416332
      UniProtKB/TrEMBL
      H0YBF7
      Conserved Domains (7) summary
      cd07641
      Location:54 → 268
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:1014 → 1070
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      cd00204
      Location:601 → 689
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:316 → 422
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:601 → 634
      ANK; ANK repeat [structural motif]
      pfam01412
      Location:439 → 555
      ArfGap; Putative GTPase activating protein for Arf
      cl26464
      Location:727 → 1003
      Atrophin-1; Atrophin-1 family

    5. NM_018482.4 → NP_060952.2  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_060952.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1.
      Source sequence(s)
      AB033075, AI494058, AP005856, BC137135, DA319233
      Consensus CDS
      CCDS6362.1
      UniProtKB/Swiss-Prot
      B2RNV3, Q9ULH1
      UniProtKB/TrEMBL
      H0YBF7
      Related
      ENSP00000429900.1, ENST00000518721.6
      Conserved Domains (8) summary
      cd07641
      Location:54 → 268
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:1071 → 1127
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      cd00204
      Location:601 → 689
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:316 → 422
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      pfam00169
      Location:326 → 411
      PH; PH domain
      pfam01412
      Location:439 → 555
      ArfGap; Putative GTPase activating protein for Arf
      pfam12796
      Location:582 → 667
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:601 → 634
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      130052104..130443674 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421810.1 → XP_047277766.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X14

    2. XM_047421806.1 → XP_047277762.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X11

    3. XM_017013468.2 → XP_016868957.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X9

      UniProtKB/TrEMBL
      H0YBF7
      Conserved Domains (8) summary
      cd11965
      Location:1015 → 1071
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      cd00204
      Location:545 → 633
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:260 → 366
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      pfam00169
      Location:270 → 355
      PH; PH domain
      pfam01412
      Location:383 → 499
      ArfGap; Putative GTPase activating protein for Arf
      pfam12796
      Location:526 → 611
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:545 → 578
      ANK; ANK repeat [structural motif]
      cl12013
      Location:1 → 209
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    4. XM_047421804.1 → XP_047277760.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X10

    5. XM_047421800.1 → XP_047277756.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X2

      UniProtKB/Swiss-Prot
      B2RNV3, Q9ULH1

    6. XM_047421799.1 → XP_047277755.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1

    7. XM_047421805.1 → XP_047277761.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X10

    8. XM_011517052.3 → XP_011515354.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011515354.1

      UniProtKB/TrEMBL
      H0YBF7
      Conserved Domains (7) summary
      cd07641
      Location:54 → 268
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:1074 → 1130
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      cd00204
      Location:604 → 692
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:319 → 425
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:604 → 637
      ANK; ANK repeat [structural motif]
      pfam01412
      Location:442 → 558
      ArfGap; Putative GTPase activating protein for Arf
      cl26464
      Location:727 → 1063
      Atrophin-1; Atrophin-1 family

    9. XM_047421807.1 → XP_047277763.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X11

    10. XM_047421808.1 → XP_047277764.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X12

    11. XM_047421801.1 → XP_047277757.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A0A0MRE5

    12. XM_011517053.2 → XP_011515355.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X3

      See identical proteins and their annotated locations for XP_011515355.1

      UniProtKB/TrEMBL
      H0YBF7
      Conserved Domains (8) summary
      cd07641
      Location:47 → 261
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:1067 → 1123
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      cd00204
      Location:597 → 685
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:312 → 418
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      pfam00169
      Location:322 → 407
      PH; PH domain
      pfam01412
      Location:435 → 551
      ArfGap; Putative GTPase activating protein for Arf
      pfam12796
      Location:578 → 663
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:597 → 630
      ANK; ANK repeat [structural motif]

    13. XM_006716565.3 → XP_006716628.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X7

      UniProtKB/TrEMBL
      H0YBF7
      Conserved Domains (8) summary
      cd11965
      Location:1018 → 1074
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      cd00204
      Location:548 → 636
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:263 → 369
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      pfam00169
      Location:273 → 358
      PH; PH domain
      pfam01412
      Location:386 → 502
      ArfGap; Putative GTPase activating protein for Arf
      pfam12796
      Location:529 → 614
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:548 → 581
      ANK; ANK repeat [structural motif]
      cl12013
      Location:1 → 212
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    14. XM_017013467.3 → XP_016868956.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X5

      UniProtKB/TrEMBL
      H0YBF7

    15. XM_047421809.1 → XP_047277765.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X13

    16. XM_047421802.1 → XP_047277758.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X6

    17. XM_047421803.1 → XP_047277759.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X8

    18. XM_047421811.1 → XP_047277767.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X15

      Related
      ENSP00000429391.1, ENST00000524124.5

    19. XM_047421812.1 → XP_047277768.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X16

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      131178779..131571038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360532.1 → XP_054216507.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X14

    2. XM_054360528.1 → XP_054216503.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X11

    3. XM_054360525.1 → XP_054216500.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X9

    4. XM_054360526.1 → XP_054216501.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X10

    5. XM_054360517.1 → XP_054216492.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X2

    6. XM_054360515.1 → XP_054216490.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1

    7. XM_054360527.1 → XP_054216502.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X10

    8. XM_054360516.1 → XP_054216491.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1

    9. XM_054360529.1 → XP_054216504.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X11

    10. XM_054360518.1 → XP_054216493.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X3

    11. XM_054360519.1 → XP_054216494.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X4

    12. XM_054360530.1 → XP_054216505.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X12

    13. XM_054360520.1 → XP_054216495.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X17

    14. XM_054360523.1 → XP_054216498.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X7

    15. XM_054360521.1 → XP_054216496.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X5

    16. XM_054360531.1 → XP_054216506.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X13

    17. XM_054360522.1 → XP_054216497.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X6

    18. XM_054360524.1 → XP_054216499.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X8

    19. XM_054360533.1 → XP_054216508.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X15

    20. XM_054360534.1 → XP_054216509.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X16

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ULH1.4 GenPept UniProtKB/Swiss-Prot:Q9ULH1

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